HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

alpha Subunit Glycoprotein Hormones

Subscribe to New Research on alpha Subunit Glycoprotein Hormones

The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.

Also Known As:

Glycoprotein Hormones, alpha Subunit; ASGPH; CG-alpha; Chorionic Gonadotropin, alpha; Chorionic Gonadotropin, alpha Subunit; Common alpha Subunit Glycoprotein Hormones; FSH-alpha; Follicle Stimulating Hormone, alpha Subunit; Glycoprotein Hormones, alpha Chain; Glycoprotein Hormones, alpha Polypeptide; HCG-alpha; LH-alpha; Lutotropin-alpha; TSH-alpha; CG alpha; FSH alpha; HCG alpha; LH alpha; Lutotropin alpha; TSH alpha; Thyroid Stimulating Hormone, alpha Subunit; FSH, alpha Subunit; Follicle-Stimulating Hormone, alpha Subunit; HCG, alpha Subunit; Human Chorionic Gonadotropin, alpha Subunit; LH, alpha Subunit; Luteinizing Hormone, alpha Subunit; Pituitary Glycoprotein Hormone, alpha Subunit; TSH, alpha Subunit; Thyroid-Stimulating Hormone, alpha Subunit; Thyrotropin alpha Subunit

Networked: 166 relevant articles (3 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lloyd, Ricardo V: 3 articles (02/2010 - 10/2008)
2.	Kovacs, Kalman: 3 articles (02/2010 - 10/2008)
3.	Scheithauer, Bernd W: 3 articles (02/2010 - 10/2008)
4.	Horvath, Eva: 3 articles (02/2010 - 10/2008)
5.	Cusimano, Michael: 2 articles (02/2010 - 10/2008)
6.	Schock, Helena: 1 article (05/2010)
7.	Lukanova, Annekatrin: 1 article (05/2010)
8.	Toniolo, Paolo: 1 article (05/2010)
9.	Hallmans, Goran: 1 article (05/2010)
10.	Wulff, Marianne: 1 article (05/2010)

Related Diseases

1.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 02/15/1985 - "After surgery and initial treatment, 126 patients with nonseminomatous germ cell tumors of the testis were followed by estimation of serum human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP), and pregnancy-specific beta-1-glycoprotein (SP-1). " 01/01/1984 - "Human chorionic gonadotrophin(hCG)-producing cells in the human placenta and in testicular germ cell tumors have been investigated by ultrastructural immunohistochemistry using labeled Fab'fragments of anti-hCG-alpha and anti-hCG-beta. " 01/01/1990 - "hCG alpha was expressed preferentially in the endocrine tumors of the thymus and non-germ-cell tumor, with rare positivity for beta-subunits of glycoprotein hormones. " 03/01/1985 - "Included in the review were an additional seven patients with undifferentiated tumors with a pathologic appearance compatible with that of a germ cell tumor and elevated levels of serum biomarkers (beta subunit of human chorionic gonadotropin [beta-HCG] +/- alpha-fetoprotein [AFP]. " 09/01/1981 - "Pregnancy Specific beta 1 Glycoprotein (PS beta 1G), human choriogonadotropin (hCG), alpha foeto protein (AFP) and Carcino Embryonic Antigen (CEA) were assayed in 58 patients with active germ cell tumors and 20 patients in complete clinical and radiological remission. "
2.	Hyperthyroidism 11/20/1979 - "to 13.6 ng/ml. In 7 patients with hyperthyroidism, serum levels of TSH-alpha varied from U.D. " 02/01/1994 - "Hyperthyroidism secondary to a pituitary adenoma secreting TSH, FSH, alpha-subunit and GH." 11/01/1985 - "Transsphenoidal removal of the tumour normalized serum hormones (T3, T4 free T4, TSH, alpha-subunit and Prl), and eradicated the clinical signs of hyperthyroidism and galactorrhoea. " 11/01/1984 - "A 43-yr-old woman, who had previously had a subtotal thyroidectomy, presented with hyperthyroidism and amenorrhea-galactorrhea due to a pituitary adenoma secreting TSH, TSH-alpha, and PRL. " 01/01/1988 - "A 36-year-old woman with hyperthyroidism, elevated blood thyroid-stimulating hormone (TSH) and alpha-subunit levels, amenorrhea, hyperprolactinemia and no evidence of acromegaly, was found to have a pituitary adenoma containing TSH, alpha-subunit and growth hormone by immunohistochemistry. "
3.	Gestational Trophoblastic Neoplasms (Trophoblastic Neoplasms, Gestational) 11/01/1980 - "All patients who were treated with chemotherapy for malignant gestational trophoblastic neoplasms at the Southeastern Regional Trophoblastic Disease Center and who experienced remission during the period January 1, 1978, through December 31, 1979, were studied in an attempt to determine if the application of an assay for the alpha subunit of human chorionic gonadotropin (hCG-alpha) could predict those patients who would have recurrences. "
4.	Neoplasms (Cancer) 11/08/1997 - "Immunohistochemistry indicated the tumor cells to be frequently positively stained for HCG alpha and FSH. " 09/01/1995 - "Both tumors were in middle-aged men; one was nonsecreting, and the other secreted follicle-stimulating hormone alpha-subunit. " 07/15/1992 - "Significant serum elevations of free hCG alpha subunit (as high as 3000 pg/ml) were found in approximately 96% of cancer patients, normal individuals, and disease controls. " 09/01/1990 - "The release of FSH, LH, alpha-subunit, or a combination of these was demonstrated in 7 tumors. " 12/01/1989 - "The inverse correlation was found between the value of D and the frequency of hCG alpha in the tumor or in the neoplastic cells (P less than 0.05). "
5.	Adenoma (Adenomas) 09/01/1993 - "Tissue from 19 of the 22 clinically nonfunctioning adenomas was cultured, and concentrations of LH, FSH, alpha-subunit, and CGA were measured. " 12/01/1987 - "GH-, PRL-, TSH-, FSH-, LH-, alpha-subunit-producing adenomas, null cell adenomas and oncocytomas showed no convincing staining. " 04/01/1998 - "Although she did not have hyperprolactinemia, the in vitro culture and immunohistochemical studies revealed that the adenoma cells produced and released PRL, in addition to TSH, alpha-subunit and GH. " 08/01/1998 - "Although the number of parathyroid cells expressing hCG-alpha was in general low, the occurrence of numerous immunoreactive cells appeared to be concentrated in primary adenoma and MEN-I (20 and 33 per cent of positive cases, respectively). " 01/01/2008 - "Having segregated "intermediate-type" adenomas (26 cases), we found significant differences between typical DG-type (47 cases) and SG-type adenomas (31 cases); SG-type adenomas had younger ages (44 vs. 50), higher frequency of macroadenomas (86% vs. 58%), invasiveness (65% vs. 38%), advanced grades (3 or 4) in Knosp's classification (50% vs. 24%), and weaker immunoreaction for GH, beta-TSH, alpha-subunit, E-cadherin, and beta-catenin. "

Related Drugs and Biologics

1.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)
2.	alpha-Fetoproteins (AFP)
3.	Hormones
4.	Antigens
5.	Pregnancy-Specific beta 1-Glycoproteins
6.	Prolactin
7.	Growth Hormone (Somatotropin)
8.	Thyrotropin (Thyroid-Stimulating Hormone)
9.	Human beta Subunit Chorionic Gonadotropin
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Thyroidectomy