Leukotrienes

A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.

Networked: 2325 relevant articles (58 outcomes, 195 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Peters-Golden, Marc: 19 articles (12/2014 - 01/2002)
2.	Haeggström, Jesper Z: 14 articles (02/2014 - 06/2002)
3.	Steinhilber, Dieter: 12 articles (02/2015 - 08/2005)
4.	Werz, Oliver: 11 articles (09/2014 - 08/2005)
5.	Bäck, Magnus: 10 articles (02/2014 - 10/2006)
6.	Henderson, William R: 10 articles (08/2013 - 01/2002)
7.	Kanaoka, Yoshihide: 10 articles (05/2013 - 10/2004)
8.	Holgate, S T: 10 articles (08/2008 - 06/2000)
9.	Levy, Bruce D: 9 articles (02/2015 - 09/2002)
10.	Serhan, Charles N: 9 articles (02/2015 - 09/2002)

Related Diseases

1.	Asthma (Bronchial Asthma) 11/01/1998 - "They also are effective in studies of chronic asthma in a wide variety of patient types demonstrating that leukotrienes are indeed important mediators of asthma. " 01/01/2012 - "Targeting LTB(4), in addition to cysteinyl leukotrienes, could be beneficial in asthma. " 12/01/1996 - "Using drugs to interfere with leukotrienes may prove beneficial in the treatment of asthma." 02/15/2013 - "Anti-leukotrienes proved effective for preventing attacks of allergic asthma. " 01/01/1991 - "The resultant allergen was effective in initiation of basophil degranulation test and of leukocytic synthesis of leukotrienes; the leukocytes were isolated from patients (adults and children) suffering from asthma and preasthma. "
2.	Inflammation 04/01/2000 - "These data suggest that leukotriene inhibition may be more effective in a subset of asthmatics in whom leukotrienes are a major contributory factor in causing allergic inflammation." 12/01/2013 - "The objective of the present study was to define the role(s) of leukotrienes in the lung pathologies accompanying eosinophil-associated chronic respiratory inflammation. " 02/01/2008 - "These studies demonstrate that 5-LO-derived leukotrienes are not required for the development or maintenance of spontaneous or NSAID-induced colonic inflammation in IL-10(-/-) mice." 05/01/2006 - "Our study demonstrates that some microbial agents can reduce the migration of dendritic cells in response to leukotrienes, with potential for differential involvement of these cells in allergic inflammation." 06/01/2015 - "Cysteinyl leukotrienes (cysLTs) are bronchoconstricting lipid mediators that amplify eosinophilic airway inflammation by incompletely understood mechanisms. "
3.	Urticaria (Hives) 05/01/2012 - "Pseudoallergens and leukotrienes (LTs) may have a role in chronic urticaria (CU). " 01/01/1989 - "We have investigated whether the inflammatory reaction in cold urticaria is associated with the release of cysteinyl-leukotrienes. " 04/01/2004 - "There is a production of leukotrienes also in chronic urticaria, which is more frequent in adults, and in atopic dermatitis, which usually has its onset in the paediatric age. " 01/01/1983 - "Possible alterations in the release of eosinophil chemotactic leukotrienes (ECL) were studied with leukocytes from 14 patients with chronic urticaria due to pseudo-allergic reactions (PAR) and from 14 healthy volunteers. " 01/01/2004 - "Because leukotrienes have potent local effects on cutaneous vasculature, leukotriene antagonists might be effective in the treatment of chronic urticaria. "
4.	Rhinitis 08/01/2013 - "In this study, authors evaluate the usefulness of cysteinyl leukotrienes (cysLT) measurement in EBC, as non-invasive diagnostic markers of allergic rhinitis in children. " 01/01/2003 - "[Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]." 08/01/2013 - "Increased cys-leukotrienes in exhaled breath condensate and decrease of PNIF after intranasal allergen challenge support the recognition of allergic rhinitis in children." 06/01/2013 - "Cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. " 03/01/2009 - "Acutely isolated mast cells from patients with allergic rhinitis exhibited store-operated Ca(2+) influx through CRAC channels and responded to cysteinyl leukotrienes. "
5.	Lung Injury 02/01/1992 - "Leukotrienes (LT) recruit polymorphonuclear leukocytes (PMN) to the lung, increase vascular permeability, and have therefore been postulated to play a role in the pathogenesis of hyperoxic lung injury. " 07/01/2004 - "In conclusion, effective treatment of phosgene-induced lung injury involves early postexposure intervention that could reduce free radical species responsible for lipid peroxidation, correct the imbalance in the GSH redox state, and prevent the release of biological mediators such as leukotrienes, which are accountable for increased permeability." 01/01/2006 - "This is the first study showing that the pharmacological inhibition of leukotrienes activity attenuates bleomycin-induced lung injury in mice. " 04/01/1990 - "Role of leukotrienes during oleic acid-induced lung injury in pigs." 09/01/1988 - "Oleic acid-induced pulmonary injury in rats: potential role of sulfidopeptide leukotrienes."

Related Drugs and Biologics

1.	Prostaglandins
2.	zileuton (Zyflo)
3.	montelukast (Singulair)
4.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	Thromboxanes
7.	Immunoglobulin E (IgE)
8.	Arachidonic Acid (Vitamin F)
9.	Histamine (Histamine Dihydrochloride)
10.	Leukotriene C4

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Immunotherapy
3.	Tourniquets
4.	Ligation
5.	Intravenous Infusions