Leukotrienes

A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.

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Networked: 4095 relevant articles (158 outcomes, 395 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Werz, Oliver: 36 articles (01/2022 - 03/2002)
2.	Peters-Golden, Marc: 23 articles (12/2014 - 01/2002)
3.	Bäck, Magnus: 22 articles (01/2019 - 10/2006)
4.	Haeggström, Jesper Z: 21 articles (01/2019 - 06/2002)
5.	Steinhilber, Dieter: 19 articles (10/2020 - 08/2005)
6.	Park, Hae-Sim: 16 articles (03/2022 - 03/2004)
7.	Rossi, Antonietta: 15 articles (01/2022 - 06/2005)
8.	Kanaoka, Yoshihide: 15 articles (01/2021 - 10/2004)
9.	Serhan, Charles N: 14 articles (01/2021 - 09/2002)
10.	Austen, K Frank: 13 articles (01/2021 - 10/2004)

Related Diseases

1.	Asthma (Bronchial Asthma) 11/01/1998 - "They also are effective in studies of chronic asthma in a wide variety of patient types demonstrating that leukotrienes are indeed important mediators of asthma. " 01/01/2005 - "Although it is still controversial whether leukotriene modifiers are more effective in patients with AIA compared with other types of asthma, because LT plays an important role in the pathogenesis of AIA, leukotriene modifiers are the preferred medication for the long-term control of AIA. " 03/16/2017 - "For adolescents and adults with persistent asthma, with suboptimal asthma control with daily use of ICS, the addition of anti-leukotrienes is beneficial for reducing moderate and severe asthma exacerbations and for improving lung function and asthma control compared with the same dose of ICS. " 01/01/2012 - "Targeting LTB(4), in addition to cysteinyl leukotrienes, could be beneficial in asthma. " 01/01/2002 - "Leukotriene synthesis inhibitors have been used successfully in the treatment of patients with asthma where they have demonstrated the ability to induce bronchial dilatation, provide protection against broncho-provocation tests and significantly diminish symptoms. "
2.	Inflammation (Inflammations) 01/01/2022 - "Its leukotriene antagonistic action can also be beneficial for the reduction of detrimental effects of leukotriene against neuro-inflammation, a hallmark feature of AD. " 01/01/2018 - "Thus, this study provides evidence that SN2 stimulation in crypt cells is mediated by the leukotriene pathway during chronic intestinal inflammation." 12/22/2016 - "The aim of this study was to investigate airway pH and cysteynil-leukotrienes (Cys-LTs) concentration (a marker of airway inflammation) in exhaled breath condensate (EBC). " 12/01/2013 - "The objective of the present study was to define the role(s) of leukotrienes in the lung pathologies accompanying eosinophil-associated chronic respiratory inflammation. " 10/02/2013 - "This study shows that dietary supplementation with BO/EO alters 20-22C PUFA levels and attenuates leukotriene production in a manner consistent with a reduction in inflammation."
3.	Aspirin-Induced Asthma 09/15/2000 - "The protective effects of leukotriene modifiers in aspirin-induced asthma." 07/01/2007 - "There is limited evidence of the use of leukotriene modifiers in preventing aspirin-induced asthma. " 09/06/2006 - "Exercice- and aspirin-induced asthma are particulary responsive to leukotriene modifiers. " 08/01/2004 - "Aspirin-induced asthma (AIA) is associated with increased production of cysteinyl leukotrienes (CysLT). " 08/01/2003 - "3. This results confirmed the role of cysteinic leukotrienes in pathogenesis of aspirin induced asthma."
4.	Rheumatoid Arthritis 10/01/1996 - "The present study was designed to compare peripheral blood neutrophil migration and leukotriene (LT) release between patients with rheumatoid arthritis (RA) and healthy controls and to correlate the neutrophil functions with clinical disease activity. " 03/01/2014 - "The role of leukotrienes in immunopathogenesis of rheumatoid arthritis." 03/26/2013 - "Leukotrienes (often leukotriene B4) as potent chemotactic agents can provoke most signs and symptoms in rheumatoid arthritis by initiating, coordinating, sustaining, and amplifying the inflammatory response, through recruitment of leukocytes. " 03/26/2013 - "The role of leukotrienes in immunopathogenesis of rheumatoid arthritis." 03/01/2008 - "Leukotrienes (LTs), and particularly LTB(4), have also been implicated in bone remodeling and disease-specifically in rheumatoid arthritis. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 10/01/2006 - "Further experimental and clinical studies are needed to determine the potential of therapeutic strategies targeting the leukotriene pathway in cardiovascular disease." 01/01/2022 - "Metabolites of the LOX pathway include cysteinyl (Cys) Leukotrienes (LT), potent proinflammatory mediators, which have also been implicated in cardiovascular disease. " 01/01/2017 - "Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases." 04/01/2012 - "Leukotrienes are proinflammatory molecules derived from dietary PUFAs and have been associated with cardiovascular disease (CVD). " 12/01/2008 - "Leukotriene modifiers in the treatment of cardiovascular diseases."

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	Prostaglandins
3.	Leukotrienes
4.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)
5.	zileuton (Zyflo)
6.	montelukast (Singulair)
7.	Lipoxygenase Inhibitors
8.	Thromboxanes
9.	Acids
10.	Arachidonic Acid (Vitamin F)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Premedication
4.	Chemoprevention
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