Neurokinin A

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.

Also Known As:

Networked: 225 relevant articles (2 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fischer, A: 5 articles (05/2011 - 03/2001)
2.	Dinh, Q T: 3 articles (05/2011 - 06/2005)
3.	Sterk, Peter J: 3 articles (03/2007 - 05/2002)
4.	Vinik, Aaron I: 2 articles (05/2015 - 10/2011)
5.	O'Dorisio, Thomas M: 2 articles (09/2014 - 10/2011)
6.	Mamikunian, Paris: 2 articles (12/2012 - 10/2011)
7.	Woltering, Eugene A: 2 articles (12/2012 - 10/2011)
8.	Mamikunian, Gregg: 2 articles (12/2012 - 10/2011)
9.	Braun, A: 2 articles (05/2011 - 06/2005)
10.	Gustavus, B: 2 articles (01/2011 - 01/2010)

Related Diseases

1.	Asthma (Bronchial Asthma) 01/01/2008 - "The bronchoconstriction caused by inhaled neurokinin A (NKA) in patients with asthma is indirect. " 06/01/2005 - "[Effect of glucocorticoid on neurokinin A in plasma and lungs of guinea pigs with asthma and molecular mechanism of the effect]." 01/01/2004 - "Inhalation of neurokinin A (NKA) causes bronchoconstriction in patients with asthma. " 01/01/2001 - "Airway hyperresponsiveness to neurokinin A (NKA) occurs in inflammatory airway diseases like asthma. " 07/01/1995 - "Neurokinin A receptor antagonists have been proposed as a new class of drugs for several applications in humans (asthma, intestinal motility, etc.). "
2.	Infection 04/15/2002 - "Viral infection (Day 4 after inoculation) was associated with a significantly greater number of labeled neurons containing Substance P/Neurokinin A (approximately 20% of total labeled neurons). " 04/15/2002 - "Immunohistochemistry was combined with retrograde labeling to characterize the effect of respiratory infection with Sendai virus on the number of Substance P/Neurokinin A-containing vagal afferent neurons whose cell bodies resided in the nodose ganglia and whose receptive fields were located in guinea pig trachea. " 09/01/1998 - "pneumoniae infection causes airway bronchoconstrictor hyper-responsiveness to neurokinin A and bradykinin and that this effect may be associated with an inhibition of epithelial NEP activity." 01/01/2014 - "The results of this study suggest at least two facts about EV71 infection, which are that: the TAC1 gene that encodes substance P and neurokinin-A is present in both PBMCs and the hypothalamus; and the up-regulation of IL-17A is sustained in the peripheral blood. " 09/01/1998 - "Airway hyper-responsiveness to neurokinin A and bradykinin following Mycoplasma pneumoniae infection associated with reduced epithelial neutral endopeptidase."
3.	Inflammation 01/01/2015 - "Reduced expression of neurokinin A in patients receiving PCT is associated with less activity and intensity of inflammation of esophageal mucosa. " 03/14/1997 - "These results indicate that endogenous neurokinin A increases the excitability of spinal neurons during persistent peripheral inflammation." 03/14/1997 - "The role of endogenous neurokinin A in changes in the excitability of spinal neurons during adjuvant-induced, peripheral inflammation was examined by determining the effect of a selective NK2 receptor antagonist, GR103537, on the nociceptive flexor reflex in rats. " 11/19/1990 - "The extensive spread and persistence of immunoreactive neurokinin A in the spinal cord may underlie some of the prolonged excitability changes evoked by brief noxious stimuli and peripheral inflammation reported by other laboratories." 04/15/2002 - "This induction appeared to be reversible as there were significantly fewer Substance P/Neurokinin A positive neurons in nodose ganglia from virus-inoculated guinea pigs at Day 28 after inoculation, a time point when virus-induced airway inflammation had all but resolved. "
4.	Migraine Disorders (Migraine) 09/01/1989 - "It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception." 06/01/1997 - "In humans, vasodilation within the meningeal vasculature has been implicated in the pathogenesis of migraine, the present experiments indicate that substance P or neurokinin A (both acting through NK1 receptors) or CGRP may be responsible." 10/01/1995 - "We measured, by RIA methods, ictal and interictal levels of substance P (SP), calcitonin-gene related peptide (CGRP) and neurokinin A (NKA) in the plasma of 30 young migraine patients with aura (MPA) and 45 migraine patients without aura (MWA), and compared the results with those of 30 age-matched controls. " 02/19/1999 - "We have carried out an immunohistochemical study on the presence of neurokinin A (NKA) and substance P (SP) in the rat caudal trigeminal nucleus (CTN) after electrical stimulation of the trigeminal ganglion (TG), used as an experimental model to induce alterations, some of which may occur during migraine attacks (release of vasoactive peptides from perivascular trigeminal axons and neurogenic inflammation). " 03/01/2006 - "The present study was aimed at verifying the clinical characteristics of a typical attack in 20 migraine patients, 10 responders and 10 non-responders to rizatriptan, and at investigating any differences in the levels of neuropeptides of the trigeminovascular or parasympathetic systems [calcitonin gene-related peptide (CGRP), neurokinin A (NKA) and vasoactive intestinal peptide (VIP) measured by radioimmunoassay methods in external jugular blood] between responders and non-responders. "
5.	Rhinitis 01/01/2010 - "The objective of this study was to analyze the release of neuropeptides (substance P, neurokinin A, and vasoactive intestinal peptide) in nasal lavage and their modification by intranasal fluticasone propionate as an established therapy in patients with allergic rhinitis. " 11/01/1999 - "In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis. "

Related Drugs and Biologics

1.	Substance P
2.	Calcitonin Gene-Related Peptide
3.	Neuropeptides
4.	Tachykinins
5.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
6.	Neuropeptide Y
7.	Neurokinin-2 Receptors (Neurokinin 2 Receptor)
8.	Capsaicin (Zostrix)
9.	Peptides
10.	preprotachykinin

Related Therapies and Procedures

1.	Rectal Administration
2.	Intradermal Injections
3.	Cystectomy
4.	Radiotherapy
5.	Moxibustion