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Merkel Cell Carcinoma

A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Also Known As:
Carcinoma, Merkel Cell; Merkel Cell Cancer; Merkle Tumors; Cancer, Merkel Cell; Cell Cancer, Merkel; Tumor, Merkel Cell; Tumors, Merkle; Merkel Cell Tumor
Networked: 1156 relevant articles (71 outcomes, 100 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Melanoma (Melanoma, Malignant)
3. Carcinoma (Carcinomatosis)
4. Squamous Cell Carcinoma (Epidermoid Carcinoma)
5. Neoplasm Metastasis (Metastasis)

Experts

1. Nghiem, Paul: 47 articles (01/2022 - 07/2007)
2. Becker, Jürgen C: 38 articles (11/2022 - 09/2008)
3. Schrama, David: 34 articles (01/2022 - 05/2006)
4. Bhatia, Shailender: 31 articles (01/2021 - 12/2011)
5. Houben, Roland: 29 articles (01/2022 - 05/2006)
6. Brownell, Isaac: 18 articles (01/2022 - 08/2011)
7. Ugurel, Selma: 17 articles (03/2022 - 05/2006)
8. Koljonen, Virve: 14 articles (03/2022 - 01/2004)
9. Parvathaneni, Upendra: 14 articles (11/2020 - 06/2013)
10. Schadendorf, Dirk: 13 articles (03/2022 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Merkel Cell Carcinoma:
1. avelumabIBA
2. Immune Checkpoint InhibitorsIBA
3. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
4. Etoposide (VP 16)FDA LinkGeneric
5. pembrolizumabIBA
6. Biomarkers (Surrogate Marker)IBA
7. Keratin-20 (Cytokeratin 20)IBA
8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
9. Peptide Receptors (Peptide Receptor)IBA
10. Radioisotopes (Radionuclides)IBA

Therapies and Procedures

1. Radiotherapy
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Immunotherapy
5. Adjuvant Radiotherapy