Xenobiotics

10/01/2006 - "Although they indeed play an important role in cancer drug resistance, their major physiological function is to provide general protection against hydrophobic xenobiotics. "
10/25/2012 - "It also affects the absorption, distribution and clearance of cancer-unrelated drugs and xenobiotics. "
07/01/2010 - "In conclusion, mutagenic activation of xenobiotics and an increased risk of cancer in the tongue were observed in this study. "
04/05/2001 - "In this study, genetic sensitivity to the genotoxic effects of carcinogenic xenobiotics as an endogenous risk factor of tumor initiation was investigated. "
01/01/1993 - "The relevance to humans of the studies in which exposure was by gavage is limited because: (i) the route is less than ideal for extrapolating to human risk from exposure by inhalation or dermally; (ii) xenobiotics often cause neoplasms at this site when given at high concentrations; and (iii) neoplasms at sites distant from the site of exposure were found in only one sex of one species. "

11/01/2001 - "Immunotoxicology studies two different effects of xenobiotics: immunosuppression and dysregulation of immune responses leading to hypersensitivity or autoimmunity. "
01/01/2014 - "Findings are correlations between allergy symptoms, severity and increased xenobiotics load."
04/01/2012 - "Although numerous models are used to evaluate the immunotoxic effects of xenobiotics on cell-mediated immunity (CMI), no holistic model for evaluating such effects on the delayed-type hypersensitivity (DTH) response has gained widespread acceptance. "
01/01/2012 - "However, since xenobiotics may have effects on more than one aspect of immune function, immunotoxicity data should be evaluated separately for evidence of suppression, stimulation, hypersensitivity, and autoimmunity."
07/01/2010 - "However, the effects of these xenobiotics on human basophils, key cells in the development of respiratory allergy, have not been investigated. "

04/01/1987 - "Its use in the dosage here proposed is expected to be beneficial for preventing deterioration of the circadian system in the elderly, for enhancing psycho-physical performances, and for gaining compliance with regard to chronic disease as well as tolerance to a number of potentially damaging xenobiotics."
06/01/1998 - "Data regarding these hepatic detoxification enzyme systems and the body s mechanisms of regulating them suggests the ability to efficiently detoxify and remove xenobiotics can affect these and other chronic disease processes. "
07/17/1996 - "Additionally, a significant number of individuals with environmental intolerance or chronic disease have impaired sulfation of phenolic xenobiotics. "
12/01/2007 - "Such effects have been extensively interpreted as useful in that they can produce greater protection against xenobiotics and "cellular stresses" of endogenous and exogenous origin, and may indicate a mechanism for the preventive role that polyphenols are believed to play against the degenerative events of aging and chronic diseases. "

07/01/2014 - "Prolonged antibiotic and antiinflammatory therapy for complicated infections exposes the body to xenobiotics that can produce several adverse effects for which oxidative damage is the proposed underlying mechanism. "
04/01/2013 - "Because of its unique function and anatomical location, the liver is exposed to a multitude of toxins and xenobiotics, including medications and alcohol, as well as to infection by hepatotropic viruses, and therefore, is highly susceptible to tissue injury. "
04/01/2012 - "Insects are also exposed to infection, osmotic or oxidative stress, and to xenobiotics or toxins. "
11/01/2008 - "This report is a summary of effects of xenobiotics and nutrients on host resistance in presently used experimental human infections adapted to rodents."
11/01/2008 - "Nutrients and xenobiotics may induce either immunostimulative or immunosuppressive effects that may affect the host resistance and the course of the disease differently in different infections. "

01/01/2010 - "It seems that this method may be useful in the treatment of poisoning with various xenobiotics."
01/01/2012 - "The aim of this study was to evaluate the significance of several sociological aspects in cases of patients after deliberate self poisoning with xenobiotics, who in the 2002-2005 period were treated in our Department. "
06/03/2015 - "The number of intoxications from xenobiotics--natural or synthetic foreign chemicals, or substances given in higher doses than typically present in humans--has risen tremendously in the last decade, placing poisoning as the leading external cause of death in the United States. "
05/01/2014 - "Diagnosis and prognosis of poisonings should be confirmed by comprehensive screening and reliable quantification of xenobiotics, for example by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). "
01/01/2012 - "2. There is an urgent need to create a reference toxicological laboratories, which would have the ability to diagnose poisoning with different xenobiotics. "