VLDL Cholesterol

Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL.

Also Known As:

Networked: 337 relevant articles (15 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carnier, June: 3 articles (06/2015 - 05/2010)
2.	de Piano, Aline: 3 articles (06/2015 - 05/2010)
3.	Dâmaso, Ana R: 3 articles (06/2015 - 05/2010)
4.	Grundy, Scott M: 3 articles (07/2010 - 11/2006)
5.	Joshi, Parag H: 2 articles (07/2015 - 06/2014)
6.	Oyama, Lila M: 2 articles (06/2015 - 05/2010)
7.	Campos, Raquel M S: 2 articles (06/2015 - 01/2012)
8.	Sanches, Priscila L: 2 articles (06/2015 - 05/2010)
9.	Corgosinho, Flávia C: 2 articles (06/2015 - 01/2012)
10.	de Leiva, Alberto: 2 articles (01/2015 - 08/2005)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 05/11/1994 - "In NIDDM patients, high-carbohydrate diets compared with high-monounsaturated-fat diets caused persistent deterioration of glycemic control and accentuation of hyperinsulinemia, as well as increased plasma triglyceride and very-low-density lipoprotein cholesterol levels, which may not be desirable." 01/01/1995 - "In this study, fish oil supplementation improved plasma VLDL cholesterol, VLDL TGs, and total TGs while having a transient deterioration in LDL cholesterol in subjects with NIDDM. " 04/01/2000 - "Type II (non-insulin-dependent) diabetes mellitus is associated with raised triglycerides and increased very low density lipoprotein cholesterol. " 11/01/1998 - "Elevated triglyceride (TG) and VLDL cholesterol levels and low levels of HDL cholesterol have also been frequently reported in NIDDM patients. " 02/01/1993 - "In the non-diabetics, the reduction in plasma cholesterol was mainly confined to the LDL fraction (276 +/- 65 vs. 132 +/- 28 mg/dl), whereas a significant fall in VLDL-cholesterol (45 +/- 19 vs. 21 +/- 10 mg/dl) was more evident in the NIDDM patients. "
2.	Insulin Resistance 12/01/2013 - "In this animal model, supplementation with d-α-tocopherol improved insulin resistance as well as the serum levels of TG and very-low-density lipoprotein-cholesterol (VLDL-C) (P < 0.05). " 01/01/2014 - "In 7-13-year-old children with BMI percentiles ranging from 0.1 to 99.6, the android/gynoid ratio was closely associated with insulin resistance and combined LDL + VLDL-cholesterol. " 01/01/1997 - "When urinary Pi and fractional Pi excretion in trial 2 were considered as dependent variables in multivariate regression analysis, they appeared unrelated to age, but positively associated with postprandial glycemia as the best predictor, followed by insulinemia, insulin resistance, to a lesser degree fasting serum PTH and the metabolic activity of stone disease, negatively associated with blood total lipids and very low density lipoprotein (VLDL) cholesterol. " 02/01/2005 - "Serum hs-CRP, insulin, glucose, total, HDL-, LDL- and VLDL-cholesterol, triglyceride levels and homeostasis model assessment for insulin resistance (HOMA-IR) index were determined. " 07/08/1999 - "Hyperinsulinemia and the central obesity that typically accompanies insulin resistance are thought to lead to overproduction of very low-density lipoprotein (VLDL) cholesterol. "
3.	Body Weight (Weight, Body) 03/01/2006 - "Plasma LDL/VLDL cholesterol or triglyceride levels of F2 mice were significantly correlated with body weight, but they were not correlated with atherosclerotic lesion sizes. " 03/01/2006 - "One significant QTL on distal chromosome 1, which accounted for major variations in plasma LDL/VLDL cholesterol and triglyceride levels, coincided with a QTL having strong effects on body weight. " 03/01/1999 - "The FOC provided 3 g of eicosapentaenoic + docosahexaenoic acid per 70 kg of body weight, and it lowered plasma triglyceride and VLDL cholesterol levels by 35% and 42%, respectively. " 10/26/2011 - "Animals fed the BRPH supplemented diet also had lower final body weight, liver weight, very low density lipoprotein cholesterol (VLDL-C), and liver cholesterol, and higher fecal fat and bile acid excretion than the control. " 11/01/2008 - "Both adhesion molecules showed significant or an apparent trend of correlations with body weight, total cholesterol, and LDL/VLDL cholesterol levels in the F2 population. "
4.	Coronary Disease (Coronary Heart Disease) 07/01/2010 - "Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS)." 05/01/1986 - "Triglyceride and very-low-density lipoprotein cholesterol were associated with total coronary heart disease by univariate but not multivariate analysis. " 07/01/2010 - "Few studies have examined very-low-density lipoprotein (VLDL) cholesterol as an independent risk factor of coronary heart disease (CHD) or its combined effects with coexisting cardiac risk factors. " 11/15/2006 - "Non-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease." 04/01/1999 - "It is concluded that both HDL and LDL cholesterol are strongly and independently associated with the prevalence of coronary heart disease, whereas the level of very low density lipoprotein cholesterol makes no statistically significant independent contribution."
5.	Weight Loss (Weight Reduction) 01/01/2013 - "Following surgery (weight loss 23.4 kg±6.2 kg; p<0.001) fasting TG (-19.1%; p=0.04), VLDL/CR-TG (-20.0%; p=0.05) decreased significantly, while fasting cholesterol, VLDL-, HDL- and LDL-cholesterol did not change. " 03/01/2011 - "After a diet of 40 days, all the patients showed a definite weight loss and significant glycaemia, creatinine, triglycerides, cholesterol, VLDL and HLDL improvement. " 01/01/2002 - "Greater weight reduction on sibutramine was accompanied by trends for greater mean reductions in serum triglycerides and very low density lipoprotein cholesterol. " 03/01/1985 - "Plasma triglycerides and very low-density lipoprotein (VLDL) cholesterol increased with exercise at constant weight (group 2) and decreased with exercise associated with weight loss (group 4). " 12/23/2000 - "Changes in concentrations of HDL cholesterol, VLDL cholesterol, and triglyceride, but not LDL cholesterol, exceed those expected either from weight loss alone or when induced by other selective therapies for low concentrations of HDL cholesterol relating to coronary heart disease."

Related Drugs and Biologics

1.	LDL Cholesterol
2.	Cholesterol
3.	HDL Cholesterol
4.	Triglycerides (Triacylglycerol)
5.	Insulin (Novolin)
6.	Adiponectin
7.	Lipoproteins (Lipoprotein)
8.	Glucose (Dextrose)
9.	Lipoprotein(a)
10.	IDL Lipoproteins (Lipoprotein, IDL)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Estrogen Replacement Therapy
3.	Ovariectomy (Oophorectomy)
4.	Intravenous Injections
5.	Intraperitoneal Injections