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Dinoprost

A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.

Also Known As:

9alpha,11beta-PGF2; Enzaprost F; Estrofan; PGF2 alpha; Prostaglandin F2 alpha; 9alpha,11beta PGF2; F2 alpha, Prostaglandin; F2alpha, Prostaglandin; alpha, PGF2; PGF2; PGF2alpha; Prostaglandin F2; Prostaglandin F2alpha; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)-

Networked: 1463 relevant articles (53 outcomes, 129 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Basu, Samar: 8 articles (01/2015 - 01/2004)
2.	Larsson, Anders: 5 articles (01/2015 - 04/2004)
3.	Kindahl, H: 5 articles (07/2006 - 01/2000)
4.	Helmersson, Johanna: 4 articles (06/2009 - 04/2004)
5.	Williams, Alistair R W: 4 articles (01/2009 - 02/2004)
6.	Jabbour, Henry N: 4 articles (01/2009 - 02/2004)
7.	Anderson, Richard A: 4 articles (01/2009 - 02/2004)
8.	Heuwieser, W: 4 articles (07/2005 - 03/2000)
9.	Archbald, L F: 3 articles (09/2006 - 04/2005)
10.	Sales, Kurt J: 3 articles (11/2005 - 02/2004)

Related Diseases

1.	Glaucoma 04/01/2015 - "Topical prostaglandin F2 α analogs (PGAs) are a relatively new class of ocular hypotensive drugs, which have made a huge impact on the treatment of glaucoma in dogs. " 04/01/2015 - "Pharmacology of topical prostaglandin F2 α analogs and their place in the treatment of glaucoma in small animals." 05/15/2005 - "The human FP-R (F2alpha prostaglandin receptor) is a Gq-coupled heptahelical ectoreceptor, which is of significant medical interest, since it is a potential target for the treatment of glaucoma and preterm labour. " 10/01/1997 - "[Glaucoma therapy with prostaglandin F2 alpha derivatives]." 03/01/1993 - "Due to its excellent pharmacokinetic properties, the isopropyl ester form of PGF2 alpha (PGF2 alpha-IE) is a much more potent ocular hypotensive agent and appeared to be better suited for the management of glaucoma, than PGF2 alpha itself or any currently used glaucoma drug. "
2.	Hemorrhage 01/01/1973 - " PGF2alpha is very effective for the induction and stimulation of labor and is advantageous for its favorable effect to the fetus and its decreasing of postpartum bleeding." 11/01/1991 - "In the previous studies by the authors, it was shown that various types of changes in electrocardiograph were produced by injection of a small dose of PGF2 alpha into the basal cistern of rabbits which were studied to examine the mechanisms of those in humans with subarachnoid bleeding. " 01/01/1989 - "The aim of this study was to investigate, in vivo, the effects of 15 methyl-prostaglandin F2 alpha (Prostinfenem, Upjohn, Sweden) on uterine activity and hemorrhage. " 12/01/1995 - "[Treatment of post-partum atonic hemorrhage with prostaglandin F2 alpha analogs]." 01/01/1992 - "Conservative treatment, including bladder irrigation with physiological saline and instillation of prostaglandin F2 alpha, failed to totally control hemorrhage. "
3.	Endometritis 09/01/2002 - "Administration of PGF2 alpha between 20 and 26 DIM to cows with endometritis that did not have a palpable corpus luteum was associated with a significant reduction in pregnancy rate. " 07/01/2005 - "It is concluded that application of PGF2alpha in the 4th and 6th week post partum in a 14 day interval in cases of severe endometritis is more effective than the application of the same treatment two weeks later." 10/01/2009 - "Effect of prostaglandin F2alpha on subclinical endometritis and fertility in dairy cows." 05/01/2006 - "In conclusion, repeated administration of PGF2alpha to cows in this herd had no effect on the prevalence of clinical endometritis at 22 and 58 days post partum, and that there was no effect on the probability of pregnancy after insemination at estrus among cows with a voluntary waiting period of > 100 days, or at timed AI at 85 days in milk when Presynch was employed." 05/01/2006 - "Repeated administration of PGF2alpha in the immediate post partum period did not reduce the prevalence of clinical endometritis on days 22 or 58 post partum (65 versus 62% on day 22 and 28.3 versus 35.2% on day 58 in Groups 1 and 2, respectively). "
4.	Dysmenorrhea (Menstrual Pain) 08/01/2011 - "The curative effect of primary dysmenorrhea treated with eye acupuncture is favorable, and the lever of PGF2alpha in peripheral blood of menstrual periods is reduced." 08/01/2011 - "[Effect on PGF2alpha in plasma in primary dysmenorrhea treated with eye acupuncture]." 08/01/2003 - "The results show that antagonism of both PGF2alpha and ACh are the major mechanisms for treating dysmenorrhea by Wen-Jing Tang. " 07/01/1990 - "[Effects of danggui shaoyao powder on blood rheological indexes and prostaglandin F2 alpha in dysmenorrhea patients]." 03/01/1988 - " Increased prostaglandin synthesis leads to inflammatory processes and the traumatization of the endometrium (high PGF2alpha level), but IUDs also often cause secondary dysmenorrhea. "
5.	Endometriosis (Adenomyosis) 08/01/1997 - "The aim of this study was to see whether PGF2alpha concentration in follicular fluid varies according to the presence or absence of remaining endometriotic lesions in the pelvis of women with endometriosis. " 08/01/1997 - "Concentrations of prostaglandin F2alpha in follicular fluid from women with endometriosis." 01/01/1988 - "Prostaglandin F2 alpha and E2 release by peritoneum with and without endometriosis." 01/01/1987 - "Estimation of 13, 14-dihydro-15-keto-prostaglandin F2 alpha (PGF2 alpha M) in patients with endometriosis." 08/01/1986 - "An estimation of PGF2 alpha in the peritoneal fluid may have prognostic value in the evaluation of infertile patients, especially those with mild endometriosis or in whom the problem is unexplained."

Related Drugs and Biologics

1.	Dinoprost
2.	Dinoprostone (PGE2)
3.	Prostaglandins
4.	latanoprost (Xalatan)
5.	Oxytocin (Pitocin)
6.	Arachidonic Acid (Vitamin F)
7.	Prostaglandins E (PGE)
8.	Gonadotropin-Releasing Hormone (GnRH)
9.	Epoprostenol (Prostacyclin)
10.	Progesterone

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Intramuscular Injections
4.	Ligation
5.	Intravenous Injections