HLA-C Antigens (HLA-C)

Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

Also Known As:

Networked: 379 relevant articles (11 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carrington, Mary: 10 articles (12/2014 - 09/2002)
2.	Ståhle, Mona: 9 articles (08/2015 - 01/2005)
3.	Moffett, Ashley: 8 articles (09/2015 - 10/2004)
4.	Bowcock, Anne M: 6 articles (12/2015 - 04/2004)
5.	Trowsdale, John: 6 articles (01/2015 - 09/2002)
6.	Capon, Francesca: 6 articles (01/2013 - 03/2002)
7.	Trembath, Richard C: 6 articles (01/2013 - 09/2002)
8.	Mallbris, Lotus: 6 articles (11/2010 - 08/2003)
9.	Parham, Peter: 5 articles (11/2015 - 11/2010)
10.	Kuśnierczyk, Piotr: 5 articles (04/2015 - 01/2003)

Related Diseases

1.	Infection 10/01/2014 - "Recently, HLA-C expression levels were shown to be correlated with protection against multiple outcomes of HIV-1 infection; however, the underlying mechanisms are poorly understood. " 04/01/2010 - "KIR and HLA-C protection in both treatment response and spontaneously resolving HCV was validated at the allelic level, in which KIR2DL3-HLA-Cw*03 was associated with SVR (P = 0.004, OR = 3.4, 95% CI = 1.5-8.7) and KIR2DL3/KIR2DL3-HLA-Cw*03 was associated with spontaneous resolution of HCV infection (P = 0.01, OR = 2.3, 95% CI = 1.2-4.4). " 01/01/2009 - "In this study, we have identified the major histocompatibility complex class I C molecule (HLA-C) as an attachment factor in facilitating HCoV-HKU1 spike (S)-mediated infection. " 10/01/2015 - "In cohorts of human patients, resolution of HCV infection has been associated with homozygosity for both C1(+)HLA-C and its cognate inhibitory receptor, KIR2DL3. " 01/01/2015 - "Genome-wide association studies (GWASs) have revealed several genetic loci associated with HIV-1 outcome following infection (e.g., HLA-C at 6p21.33) in multi-ethnic populations with genetic heterogeneity and racial/ethnic differences among Caucasians, African-Americans, and Hispanics. "
2.	Psoriatic Arthritis 03/01/1999 - "The aim of this investigation was to compare the frequency of alleles at the HLA-C locus in patients with psoriatic arthritis to that in the disease free population and to relate the HLA genes to disease phenotype in psoriatic arthritis (PsA). " 12/01/2014 - "Significance of association of HLA-C and HLA-E with psoriatic arthritis." 01/01/2014 - "The Region Centromeric to HLA-C Is a Key Region for Understanding the Phenotypic Variability of Psoriatic Arthritis." 01/01/2006 - "HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis." 12/01/2005 - "HLA-C locus alleles distribution in patients from northern Poland with psoriatic arthritis--preliminary report."
3.	Melanoma (Melanoma, Malignant) 08/15/2006 - "Therefore, the goal of this study was to investigate the involvement of early changes in CD8 T cells and CD56 natural killer (NK) cells expressing NK receptors in different HLA-C dimorphism groups of melanoma patients. " 05/01/2013 - "For this purpose, KIR genotyping by PCR-SSP and HLA-C genotyping by reverse PCR-SSO were performed in 187 melanoma patients and 200 matched controls. " 08/15/2006 - "Natural killer receptors on CD8 T cells and natural killer cells from different HLA-C phenotypes in melanoma patients." 01/01/2006 - "Remarkably, individuals homozygous for group 2 HLA-C alleles (HLA-C(Lys80)) seem to be associated with metastatic progression of melanoma. " 01/01/2006 - "Moreover, the influence of HLA-C on melanoma has not yet been well established. "
4.	Graft vs Host Disease (Graft-Versus-Host Disease) 08/01/2000 - "Sequential analysis of HLA-C-specific killer cell inhibitory receptor (CD158b) expressing peripheral blood mononuclear cells during chronic graft-versus-host disease." 12/01/1995 - "Five of nine patients who received BMT from HLA-C mismatched unrelated donors developed > grade II graft-vs.-host disease (GVHD), and four developed graft rejection. " 12/18/2014 - "Life-threatening graft-versus-host disease (GVHD) limits the use of HLA-C-mismatched unrelated donors in transplantation. " 01/01/2014 - "HLA-C mismatches are clearly associated to alloreactivity after hematopoietic stem-cell transplantation; in a number of large cohorts, HLA-C mismatches are correlated to an increased risk of acute graft-versus-host disease (GVHD) or even impaired survival. " 11/01/1996 - "In the unrelated BMT group, the transplant-related complications of mortality, graft-versus-host disease (GVHD), and graft rejection, were significantly higher in molecular HLA-C mismatched than matched patients (67% vs 14%, P < 0.02; 50% vs 7%, P < 0.02; 42% vs 0, P < 0.02). "
5.	HIV Infections (HIV Infection) 04/05/2013 - "We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. " 10/01/2012 - "Two polymorphisms affecting HLA-C surface expression (rs9264942 and rs67384697) have recently been identified, and shown to influence progression of HIV infection. " 05/01/2012 - "This is, to our knowledge, the first in vivo evidence supporting the protective role of HLA-C-restricted responses in nonwhites during HIV infection." 11/01/2010 - "The potential importance of HLA-C-restricted CD8+ cytotoxic T lymphocytes (CTL) in HIV infection remains undetermined. " 04/01/2010 - "Characterization of an HLA-C-restricted CTL response in chronic HIV infection."

Related Drugs and Biologics

1.	HLA-B Antigens (HLA-B)
2.	HLA-A Antigens (HLA-A)
3.	HLA-DRB1 antigen (HLA DRB1)
4.	Antigens
5.	KIR Receptors
6.	HLA-DQB1 antigen (HLA DQB1)
7.	mica
8.	HLA-DQ Antigens (HLA-DQ)
9.	HLA-DP Antigens (HLA-DP)
10.	Dihydrotachysterol (AT 10)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Homologous Transplantation (Allograft)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Transplantation (Transplant Recipients)