HLA-B Antigens (HLA-B)

Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.

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Networked: 1869 relevant articles (41 outcomes, 234 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Wen-Hung: 26 articles (01/2022 - 04/2004)
2.	Carrington, Mary: 26 articles (11/2021 - 08/2002)
3.	Walker, Bruce D: 23 articles (11/2021 - 12/2004)
4.	Sukasem, Chonlaphat: 22 articles (01/2022 - 01/2014)
5.	Pirmohamed, Munir: 21 articles (01/2021 - 06/2004)
6.	Mallal, Simon: 20 articles (01/2018 - 03/2004)
7.	Hung, Shuen-Iu: 19 articles (01/2021 - 04/2004)
8.	Brander, Christian: 15 articles (11/2021 - 12/2004)
9.	Goulder, Philip J R: 15 articles (11/2021 - 12/2004)
10.	Tassaneeyakul, Wichittra: 15 articles (01/2021 - 09/2009)

Related Diseases

1.	Hypersensitivity (Allergy) 02/01/2011 - "To determine the frequencies of HLA-B alleles in Ugandan patients in the NORA substudy of the DART trial and to compare HLA-B allele frequencies in those with and without clinically diagnosed hypersensitivity reaction (HSR). " 04/01/2008 - "This paper outlines the design of a study to evaluate the utility of prospective screening for HLA-B*5701 to reduce the incidence of ABC hypersensitivity in an ABC-naïve population of HIV-infected subjects. " 08/13/2022 - "However, HLA-B*13:01-DDS-TCR immune synapse that plays role in drug-induced hypersensitivity syndrome (DIHS) associated T cells activation remains uncharacterized. " 01/01/2022 - "The establishment of a pharmacogenetics screening program in Qatar for cost effective interventions aimed at preventing drug-induced hypersensitivity can be aided by the highly prevalent HLA-B pharmacogenetic markers detected here." 01/01/2022 - "Background: The HLA-B is the most polymorphic gene, play a crucial role in drug-induced hypersensitivity reactions. "
2.	Disease Progression 09/10/2011 - "The fact that such adaptations are driven by the HLA-B molecules that provide best protection against HIV-1 disease progression has important implications for our understanding of HIV evolution." 01/01/2018 - "These studies demonstrate that HLA-B*27:02 mediates protection against HIV disease progression that is at least as strong as or stronger than that mediated by HLA-B*27:05. " 01/01/2018 - "We show that HLA-B*27:02 is also protective against HIV disease progression, but the CD8+ T-cell immunodominance hierarchy of HLA-B*27:02 differs strikingly from that of HLA-B*27:05. " 01/01/2022 - "HLA-B*27 and B*57 are often associated with a delayed HIV disease progression, but the exact correlates that provide superior immunity against HIV are not known. " 01/10/2019 - "HLA-B*13:02 and B*40:06 might be associated with delayed disease progression for HIV infected persons in Henan. "
3.	Gout 01/01/2023 - "From Chinese perspective of healthcare system, HLA-B*58:01 genotyping strategy was cost-effective for gout patients with mild to moderate CKD in mainland China, especially in the most developed area, such as Beijing and Shanghai. " 11/01/2022 - "The objective of the present study was to evaluate the interaction and association between genetic polymorphisms of HLA-B and the NLRP3 gene in Mexican patients with gout. " 08/01/2020 - "The aim of this study was to conduct a cost-utility analysis of sequential ULT treatment strategies for gout, including strategies with and without HLA-B*58:01 genotyping prior to treatment initiation, with a view to inform optimal gout management in Singapore.Materials" 11/01/2014 - "Cost-Effectiveness Of Routine Testing For Hla-B*5801 In Caucasian Patients Newly Diagnosed With Gout In Portuguese Nhs Hospitals." 01/01/2014 - "The cost of gout management, incidence of SJS/TEN, case fatality rate of SJS/TEN, and cost of genetic testing are considered very influential parameters on the cost-effectiveness value of HLA-B*5801 testing. "
4.	COVID-19 01/01/2022 - "The alleles associated with severe COVID-19 were HLA-B*41, -B*42, -C*16, and -C*17, whereas HLA-B*15, -C*7, and -C*12 were significantly associated with protection against mortality. " 01/01/2022 - "We observed that an age-dependent effect of HLA-B*51:01 carriage [odds ratio (OR)=0.48 (0.28-0.80), Pbonf <0.036] is protective against severe COVID-19. " 10/01/2023 - "Augusto et al.'s recent study in Nature unveils a strong association of HLA-B*15:01 with asymptomatic COVID-19, representing an important contribution to genetics in COVID-19." 10/01/2023 - "made using a novel mobile phone application-based COVID-19 Citizen Science Study that an HLA genetic variant, HLA-B*15:01, is associated with asymptomatic SARS-CoV-2 infection. " 01/01/2022 - "This study aimed to identify HLA-B and -C genotypes among 69 Egyptian patients with COVID-19 and correlate them with disease outcomes and other clinical and laboratory data. "
5.	Cicatrix (Scar) 10/01/2015 - "Compared with the previous retrospective cohort study, a significant reduction in SCARs was observed in HLA-B*58:01-positive patients (0 vs. 18%; P = 0.002). " 01/01/2022 - "The findings of this study showed that the incidence of SCARs of CBZ/OXC was significantly lower (p < 0.001) in the HLA-B*15:02 screening arm than in the non-screening arm. " 01/01/2022 - "384 patient data were included in this study to investigate the clinical decision on CBZ/OXC usage before and after the HLA-B*15:02 PGx testing, and 1,539 patient data were included in this study to demonstrate the incidence of CBZ/OXC-induced SCARs and SJS between HLA-B*15:02 tested and non-tested patients. " 01/01/2022 - "HLA-B*15:02 as a risk factor of PHT-induced SCARs was reported in numerous studies with inconsistent results. " 01/01/2020 - "This study confirmed 8 risk factors, including HLA-B*58:01, for SCARs and identified 3 risk factors for MCARs in Kinh Vietnamese. "

Related Drugs and Biologics

1.	HLA-A Antigens (HLA-A)
2.	HLA-C Antigens (HLA-C)
3.	Allopurinol (Remid)
4.	abacavir (Ziagen)
5.	HLA-DRB1 Chains (HLA DRB1)
6.	Antigens
7.	Epitopes
8.	HLA-DQB1 antigen (HLA DQB1)
9.	Febuxostat
10.	HLA Antigens (Human Leukocyte Antigens)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Transplantation
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Secondary Prevention