Gouty Arthritis

Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.

Also Known As:

Networked: 515 relevant articles (48 outcomes, 77 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation
2.	Gout
3.	Pain (Aches)
4.	Ankylosing Spondylitis
5.	Osteoarthritis

Experts

1.	Schlesinger, Naomi: 10 articles (11/2012 - 02/2002)
2.	So, Alexander: 6 articles (03/2015 - 01/2007)
3.	Rasool, Mahaboobkhan: 5 articles (01/2015 - 01/2010)
4.	Schumacher, H Ralph: 5 articles (01/2013 - 02/2002)
5.	Janssen, Matthijs: 4 articles (12/2015 - 06/2012)
6.	Lan, Zhou: 4 articles (11/2015 - 05/2013)
7.	Chen, Lvyi: 4 articles (11/2015 - 05/2013)
8.	Bardin, Thomas: 4 articles (01/2013 - 07/2009)
9.	Harper, Jacquie L: 4 articles (12/2011 - 06/2007)
10.	Perretti, Mauro: 4 articles (04/2011 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gouty Arthritis:

1.	Uric Acid (Urate)IBA 05/01/1996 - "It produced significant protective effects in sodium urate gouty arthritis in dogs. " 10/05/2014 - "Our previous study demonstrates that Dolichos falcata Klein (DF) ameliorates the gouty arthritis induced by monosodium urate (MSU) crystals, and one of the active components, doliroside A, contributed to the anti-gouty arthritis effect of DF according to the in vitro study. " 09/01/2015 - "The present study was to evaluate the clinical value of dual-energy computed tomography (DECT) for detecting monosodium urate crystals in patients with gouty arthritis. " 01/01/2015 - "The present study was undertaken to evaluate the therapeutic effect of PRP15 in rat gouty arthritis induced by monosodium urate (MSU) crystals. " 07/01/2014 - "The aim of the study was to investigate the sensitivity and specificity of dual-energy computed tomography in the diagnosis of acute gouty arthritis, and the related risk factors for urate crystal deposition. "
2.	ColchicineFDA LinkGeneric 08/01/1966 - "[Colchicine in acute gouty arthritis: clinical and metabolic studies]." 12/01/2015 - "Colchicine has been used for the treatment and prevention of gouty arthritis and has been reported to have an anticancer effect in vitro. " 11/01/2014 - "Nonsteroidal anti-inflammatory drugs and colchicine are recommended first-line treatments for acute gouty arthritis attacks. " 10/01/2014 - "Colchicine modulates multiple pro- and antiinflammatory pathways associated with gouty arthritis. " 05/01/2014 - "Colchicine-responsive protracted gouty arthritis with systemic inflammatory reactions."
3.	etoricoxibIBA 01/01/2013 - "We tried to assess the safety and efficacy of etoricoxib in the treatment of acute gouty arthritis in China. " 08/01/2005 - "Etoricoxib is a highly selective COX-2 inhibitor (coxib) approved in Europe for the treatment of osteoarthritis (OA), rheumatoid arthritis and acute gouty arthritis. " 05/01/2004 - "The recommended daily dose for acute pain relief treatment from primary dysmenorrhea and acute gouty arthritis is 120 mg. This review summarizes the published preclinical and clinical data relevant to the use of etoricoxib in clinical practice." 05/01/2004 - "The recommended dosage of etoricoxib is 60 mg/day for osteoarthritis, 90 mg/day for rheumatoid arthritis and 120 mg/day for acute gouty arthritis. " 02/01/2003 - "Etoricoxib has been approved in the UK as a once-daily medicine for symptomatic relief in the treatment of osteoarthritis (OA), rheumatoid arthritis (RA) and acute gouty arthritis. "
4.	Indomethacin (Indometacin)FDA LinkGeneric 02/01/1998 - "Indomethacin rectal suppository in the treatment of acute gouty arthritis." 11/25/1981 - "We present a patient in whom indomethacin treatment for acute gouty arthritis induced reversible azotaemia and hyperkalaemia. " 04/29/1967 - "Regimen of indomethacin therapy in acute gouty arthritis." 09/05/1980 - "Indomethacin-induced hyperkalemia in three patients with gouty arthritis." 09/05/1980 - "We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin. "
5.	canakinumabFDA Link 11/01/2012 - "Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions." 10/01/2010 - "Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study." 12/01/2013 - "Total IL-1β kinetics and canakinumab pharmacokinetics were characterized by a population-based pharmacokinetic-binding model, where the estimated apparent in vivo dissociation constant (signifying binding affinity of canakinumab to circulating IL-1β) was 0.99 nmol/L in gouty arthritis patients. " 12/01/2013 - "Pharmacokinetic and pharmacodynamic properties of canakinumab in patients with gouty arthritis." 08/01/2013 - "Canakinumab (Ilaris®), an anti-interleukin-1β monoclonal antibody, is a novel approach to treat acute gouty arthritis flares in a targeted population of patients in whom treatment options are limited. "
6.	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 08/01/2013 - "Anakinra is an effective and safe alternative treatment for acute gouty arthritis in medically complex hospitalized patients who fail or cannot undergo more conventional therapy." 01/01/2013 - "Efficacy of anakinra in gouty arthritis: a retrospective study of 40 cases." 08/01/2013 - "To report our experience with the efficacy and safety of anakinra for acute gouty arthritis in medically complex hospitalized patients. " 08/01/2013 - "Treatment of acute gouty arthritis in complex hospitalized patients with anakinra." 01/01/2013 - "Anakinra may be efficient in gouty arthritis, is relatively well tolerated with short-term use, and could be a relevant option in managing gouty arthritis when conventional therapies are ineffective or contraindicated. "
7.	Etodolac (Lodine)FDA LinkGeneric 01/01/1990 - "The efficacy of etodolac in such conditions is confirmed by the results from eight controlled clinical studies in patients with gouty arthritis, tendinitis and bursitis, and acute sports injuries. " 01/01/1990 - "In studies of acute gouty arthritis, significant improvement from baseline were seen for all efficacy parameters evaluated for both the etodolac- and naproxen-treated patients. " 01/01/1991 - "A double-blind, parallel group study was carried out in 61 patients suffering from acute gouty arthritis to compare the effectiveness of etodolac and naproxen in the relief of symptoms. " 01/01/1990 - "In multiple dose studies of acute gouty arthritis and musculoskeletal conditions, etodolac 200 or 300 mg twice a day (b.i.d.) or 200 mg three times a day (t.i.d.) was compared with naproxen 500 mg b.i.d. " 01/01/1990 - "In summary, etodolac therapy for pain following surgery, in acute gouty arthritis and in acute musculoskeletal conditions resulted in analgesia comparable to that provided by several well-established analgesic or anti-inflammatory agents."
8.	Allopurinol (Remid)FDA LinkGeneric 01/01/2015 - "Gouty arthritis requiring allopurinol is associated with an excess risk of major or hip fracture, with an allopurinol dose effect evident in women such that women taking the highest doses of allopurinol--suggestive of more severe disease--were at increased risk relative to women taking lower doses." 01/01/2010 - "Despite continued allopurinol therapy the gouty arthritis of the peripheral joints re-occurred. " 07/19/1980 - "Reinstitution of allopurinol therapy for gouty arthritis after cutaneous reactions." 09/01/1992 - "Nine patients with renal insufficiency and chronic tophaceous gouty arthritis, who had to interrupt their allopurinol therapy because of an allergic-type pruritic maculopapular eruption, were enrolled in an allopurinol oral desensitization protocol using a schedule of gradually increasing doses. " 01/01/2002 - "Gouty arthritis in the presence of continuous hyperuricemia, tophyses and urolithiasis is treated with allopurinol. "
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/01/2014 - "However, whether glucocorticoid has the same or preferable effect as oral NSAIDs on patients with acute gouty arthritis irrespective of gastrointestinal and cardiovascular risks factor remains unknown. " 01/01/2014 - "To estimate effectiveness of ambulatory treatment of gouty arthritis (GA) using non-steroidal anti-inflammatory agents (NAIA) and detect factors associated with the impairment of the functional state of kidneys during short-term therapy. " 03/01/2011 - "Non-steroidal anti-inflammatory drugs (NSAIDS) are the first line of therapy in acute gouty arthritis. " 09/01/1998 - "Extreme caution is necessary when prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of acute gouty arthritis in the elderly. " 01/01/1998 - "For the management of acute gouty arthritis, non-steroidal anti-inflammatory drugs (NSAIDs) are the drugs of choice. "
10.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 12/01/2014 - "Efficacy of Canakinumab vs. triamcinolone acetonide according to multiple gouty arthritis-related health outcomes measures." 07/01/1994 - "Comparison of adrenocorticotropic hormone and triamcinolone acetonide in the treatment of acute gouty arthritis." 01/01/1993 - "Comparison of triamcinolone acetonide with indomethacin in the treatment of acute gouty arthritis." 10/01/2010 - "Our findings indicate that canakinumab 150 mg provides rapid and sustained pain relief in patients with acute gouty arthritis, and significantly reduces the risk of recurrent flares compared with triamcinolone acetonide." 01/01/2011 - "In this eight-week, single-blind, double-dummy, dose-ranging study, patients with acute Gouty Arthritis flares who were unresponsive or intolerant to--or had contraindications for--non-steroidal anti-inflammatory drugs and/or colchicine were randomized to receive a single subcutaneous dose of canakinumab (10, 25, 50, 90, or 150 mg) (N = 143) or an intramuscular dose of triamcinolone acetonide 40 mg (N = 57). "

Therapies and Procedures

1.	Analgesia 09/01/2011 - "Acupuncture combined with infrared irradiation achieves superior efficacy on acute gouty arthritis as compared with oral medication of Indomethachin and the therapy provides a significant effect on analgesia and does not bring the damage of liver function." 01/01/2013 - "Qigui Tongfengshu granule is significantly effective for gouty arthritis, and has the effect of anti-inflammation, analgesia and reduction in blood uric acid." 01/01/1990 - "In summary, etodolac therapy for pain following surgery, in acute gouty arthritis and in acute musculoskeletal conditions resulted in analgesia comparable to that provided by several well-established analgesic or anti-inflammatory agents."
2.	Renal Dialysis (Hemodialysis) 06/01/1993 - "In both cases initiation of hemodialysis treatment, at first temporally exacerbated gouty arthritis, but thereafter gradually eliminated the tophi. " 06/01/1993 - "Gouty arthritis in CRF patient, which does not respond to the conservative therapy, should be considered to be one of the indices for commencement of hemodialysis." 06/01/1993 - "Therapeutic effect of hemodialysis on gouty arthritis and tophi in 2 patients with chronic renal failure (CRF) is described. " 06/01/1993 - "[Therapeutic effect of hemodialysis on gouty arthritis and tophi in 2 patients with chronic renal failure]." 04/01/1964 - "RECURRENT ACUTE (?GOUTY) ARTHRITIS IN CHRONIC RENAL FAILURE TREATED WITH PERIODIC HEMODIALYSIS."
3.	Aftercare (After-Treatment) 02/01/2009 - "The follow-up period (mean +/- standard deviation) was 3.9 +/- 1.1 years in group 1 and 2.4 +/- 0.3 years in group 2. After treatment, both groups showed a significant improvement in the number of acute attacks of gouty arthritis and in their functional scores on the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale. " 09/05/1980 - "We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin. "
4.	Surgical Decompression 01/01/2013 - "Sildenafil use may cause gouty arthritis, and surgical decompression may be helpful for definitive diagnosis and symptom relief in atypical presentation of gout."
5.	Splenectomy 01/01/1952 - "[Splenomegalic neutropenia associated with gouty arthritis; successful therapy by splenectomy and splenographic and histologic considerations]."