Hip Osteoarthritis (Coxarthrosis)

Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.

Also Known As:

Networked: 903 relevant articles (43 outcomes, 137 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoarthritis
3.	Low Back Pain (Lumbago)
4.	Osteoporosis
5.	Knee Osteoarthritis

Experts

1.	Vignon, E: 11 articles (05/2008 - 10/2000)
2.	Conrozier, T: 7 articles (05/2008 - 10/2000)
3.	Bierma-Zeinstra, S M A: 6 articles (01/2016 - 04/2009)
4.	Overgaard, Søren: 6 articles (01/2015 - 01/2011)
5.	Massafra, U: 6 articles (04/2014 - 01/2005)
6.	Migliore, A: 6 articles (04/2014 - 01/2005)
7.	Tormenta, S: 6 articles (04/2014 - 01/2005)
8.	Dougados, Maxime: 6 articles (02/2014 - 02/2002)
9.	Migliore, Alberto: 6 articles (08/2012 - 06/2005)
10.	Tormenta, Sandro: 6 articles (08/2012 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hip Osteoarthritis:

1.	Hyaluronic Acid (Hyaluronan)IBA 12/01/2011 - "Clinical trials have demonstrated the safety and efficacy of hyaluronic acid-based products for the treatment of hip osteoarthritis, but data from observational studies of normal medical practice are scarce. " 10/01/2010 - "Efficacy of intraarticular hyaluronic acid injection through a lateral approach under fluoroscopic control for advanced hip osteoarthritis." 03/01/2009 - "Effect of hyaluronic acid in symptomatic hip osteoarthritis: a multicenter, randomized, placebo-controlled trial." 12/01/2006 - "This study sought to use a systematic review to ascertain the efficacy and safety of hyaluronic acid (HA) in the treatment of hip osteoarthritis (OA). " 02/01/2006 - "Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline."
2.	hylanIBA 06/01/2002 - "We studied the short-term safety and efficacy of intraarticular hylan G-F 20 (Synvisc) in patients with symptomatic hip osteoarthritis. " 06/01/2010 - "Hylan g-f 20 improves hip osteoarthritis: a prospective, randomized study." 05/01/2008 - "This prospective, observational, open study aimed to assess the efficacy and safety of hylan G-F 20 in a large cohort of patients with symptomatic hip osteoarthritis (OA), and identify predictors of clinical response. " 05/01/2008 - "Intra-articular administration of hylan G-F 20 in patients with symptomatic hip osteoarthritis: tolerability and effectiveness in a large cohort study in clinical practice." 03/01/2008 - "We prospectively included patients scheduled for intraarticular Hylan GF-20 injection to treat hip osteoarthritis. "
3.	Naproxen (Naprosyn)FDA LinkGeneric 01/01/1991 - "A standard fixed dosing regimen (S) and a variable dosing regimen (VD) of naproxen for patients with knee and hip osteoarthritis were compared in a multicentre, open, controlled, parallel 8-week trial. " 06/01/2006 - "Patients with knee osteoarthritis improved more with naproxen treatment than patients with hip osteoarthritis, as monitored by WOMAC and the SF-36 domains bodily pain and role-physical. " 12/01/2010 - "The efficacy of naproxcinod for treating the signs and symptoms of hip osteoarthritis was statistically superior to that of placebo and similar to that of naproxen. " 11/01/2014 - "Two studies evaluated efficacy and safety of tanezumab versus naproxen for treatment of knee or hip osteoarthritis (OA). " 02/26/1985 - "[Clinical trials with pirprofen and naproxen in patients with gonarthrosis and coxarthrosis]."
4.	diacetylrhein (diacerein)IBA 09/25/2006 - "This systematic meta-analysis provides evidence for the symptomatic efficacy of diacerein in the treatment of knee and hip osteoarthritis, with reasonable tolerability." 12/07/2002 - "RADIOGRAPHIC FINDINGS: The ECHODIAH study conducted to evaluate the structure-modifying effect of diacerein in hip osteoarthritis. " 01/12/2002 - "The principal objective of ECHODIAH study conducted in patients with hip osteoarthritis was to evaluate the chondroprotective effect of potential of diacerein compared with placebo. " 11/01/2001 - "Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. " 01/01/2000 - "In this study, Harpagophytum was at least as effective as a reference drug (diacerhein) in the treatment of knee or hip osteoarthritis and reduced the need for analgesic and nonsteroidal anti-inflammatory therapy."
5.	Diclofenac (SR 38)FDA LinkGeneric 01/01/1997 - "Open study of a diclofenac sodium prolonged-release in patients suffering from coxarthrosis." 01/01/1997 - "Fourty adult patients with coxarthrosis were treated for 30 days with oral diclofenac sodium at the daily dose of 150 mg: 20 of these were administered one 150 mg prolonged-release capsule per day, the other 20 received one 50 mg enteric-coated tablet every 8 hours. " 01/01/2009 - "Herein, the case of a 60-year-old woman with severe bilateral hip osteoarthritis treated with diclofenac sodium, who presented with manifestations of a spontaneous hematoma of the right thigh, is described. " 01/01/1982 - "A randomized double-blind trial was performed in 50 patients with moderate to severe coxarthrosis, 25 receiving 300 mg carprofen and 25 150 mg diclofenac-Na daily in 3 doses. " 09/01/2014 - "Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial."
6.	Ibuprofen (Motrin)FDA LinkGeneric 04/01/1977 - "[Ibuprofen in the long-term treatment of coxarthrosis. " 08/01/1975 - "[Ibuprofen in long-term treatment of coxarthrosis. " 09/01/2004 - "To compare the analgesic efficacy of single and multiple doses of ibuprofen with that of paracetamol in patients with knee or hip osteoarthritis (IPSO study). " 09/01/1992 - "Ibuprofen plus codeine, ibuprofen, and placebo in a single- and multidose cross-over comparison for coxarthrosis pain." 01/01/1988 - "Prophylactic treatment with indomethacin or ibuprofen to prevent periarticular heterotopic ossification (PHO) was investigated in a consecutive series of 200 total hip replacements (THR) performed for primary coxarthrosis in 170 patients. "
7.	Acetaminophen (Paracetamol)FDA LinkGeneric 10/01/2012 - "Treatment satisfaction after switching to another therapy in Spanish orthopaedic clinic outpatients with knee or hip osteoarthritis previously refractory to paracetamol." 08/01/2004 - "Acetaminophen (paracetamol) is recommended as the initial pharmacological treatment for knee or hip osteoarthritis. " 12/01/2015 - "Paracetamol is ineffective for spinal pain and knee and hip osteoarthritis." 09/01/2004 - "To compare the analgesic efficacy of single and multiple doses of ibuprofen with that of paracetamol in patients with knee or hip osteoarthritis (IPSO study). " 08/01/2011 - "To identify sources of heterogeneity (statistical, methodological, and clinical) in studies evaluating non-steroidal anti-inflammatory drugs (NSAIDs) vs acetaminophen in patients with knee and hip osteoarthritis (OA) to elucidate variations in outcomes. "
8.	4-hexyloxyaniline (HOA)IBA 11/01/2015 - "Hip osteoarthritis (HOA) is one of the major causes of disability in seniors and is costly to society. " 10/01/2015 - "To identify genetic associations with hip osteoarthritis (HOA), we performed a meta-analysis of genome-wide association studies (GWAS) of HOA. " 01/01/2015 - "To identify baseline radiographic features that predict hip osteoarthritis (HOA) progression, and to explore differences in these associations by race. " 01/01/2014 - "We present a case report of IB associated with moderate hip osteoarthritis (HOA). " 10/01/2013 - "To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors. "
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/01/2006 - "Hip osteoarthritis (OA) is usually managed with systemic treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs) and/or symptomatic slow-acting drugs. " 09/01/1991 - "[Role of non-steroidal anti-inflammatory agents in complex treatment of coxarthrosis (review of the literature)]." 11/15/1996 - "The treatment of hip osteoarthritis requires analgesic, NSAIDs and symptomatic slow actin drugs for osteoarthritis. " 04/01/2011 - "The WOMAC Osteoarthritis Index, physical functioning score of RAND-36 (SF-36), the use and health care system costs of doctor visits and physiotherapy associated with hip osteoarthritis, number of total hip replacements, the use of analgesic and non-steroidal anti-inflammatory drugs (NSAIDs), performance-based outcome scores and body mass index (BMI). " 06/01/2007 - "Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis."
10.	Biological Markers (Surrogate Marker)IBA 08/01/2015 - "To relate systemic biochemical markers of joint metabolism to presence, incidence, and progression of early-stage radiographic knee and/or hip osteoarthritis (OA). " 08/01/2015 - "The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK." 05/01/2015 - "We conducted a systematic review of molecular biomarkers associated with hip OA or prearthritic hip disease by searching four major electronic databases for keywords "hip", "osteoarthritis", "biomarker", and all synonyms. " 05/01/2015 - "What is the utility of biomarkers for assessing the pathophysiology of hip osteoarthritis? " 07/01/2012 - "To assess a wide spectrum of biochemical markers (biomarkers) in a large cohort of individuals with (very) early symptomatic knee and/or hip osteoarthritis (OA). "

Therapies and Procedures

1.	Arthroplasty 01/01/2015 - "Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. " 02/01/2008 - "Developmental dysplasia of the hip--good results of later total hip arthroplasty: 7135 primary total hip arthroplasties after developmental dysplasia of the hip compared with 59774 total hip arthroplasties in idiopathic coxarthrosis followed for 0 to 15 years in the Norwegian Arthroplasty Register." 09/01/2015 - "Total hip arthroplasty (THA) is a common and effective treatment of hip osteoarthritis. " 01/01/2005 - "Primary total hip arthroplasty (THA) is an effective treatment for hip osteoarthritis, assessed by whatever distribution-based measures of responsiveness. " 11/01/2012 - "Total hip arthroplasty can provide improved function in patients with neuromuscular impairment and severe coxarthrosis. "
2.	Intra-Articular Injections 04/01/2010 - "Intra-articular injections are widely used in treatment of early hip osteoarthritis and may help to offset the need for a joint replacement. " 12/01/2011 - "These results in daily clinical practice demonstrate a beneficial effect and the safety of the study product and suggest adding intra-articular injections of HyalOne to the armamentarium of conservative management of symptomatic hip osteoarthritis." 01/01/2007 - "In the current study we described US patterns concerning 490 patients affected by symptomatic hip osteoarthritis (OA) who underwent to intra-articular injections of hyaluronic products under US guidance. " 06/01/2015 - "Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle, or Hip Osteoarthritis." 01/01/2015 - "Therapeutic intraarticular injections are used in the management of hip osteoarthritis (OA). "
3.	Injections 01/01/2013 - "Individual patient data meta-analysis of trials investigating the effectiveness of intra-articular glucocorticoid injections in patients with knee or hip osteoarthritis: an OA Trial Bank protocol for a systematic review." 07/01/2011 - "Platelet-rich plasma (PRP) intra-articular ultrasound-guided injections as a possible treatment for hip osteoarthritis: a pilot study." 01/01/2006 - "Intraarticular glucocorticoid injections in rapidly destructive hip osteoarthritis." 01/01/2004 - "Ultrasound-guided steroid injections in the treatment of hip osteoarthritis: comment on the letter by Margules." 03/01/1955 - "[Phlebography of the hip in coxarthroses; 100 injections]."
4.	Exercise Therapy (Therapy, Exercise) 01/01/2015 - "The aim of the present study was to compare stance phase gait characteristics in hip osteoarthritis patients with mild to moderate symptoms participating in a randomized trial with two different interventions; patient education only or patient education followed by a 12-week supervised exercise therapy program. " 04/01/2011 - "A pragmatic randomized controlled study of the effectiveness and cost consequences of exercise therapy in hip osteoarthritis." 01/01/2016 - "To assess the effectiveness of exercise therapy added to general practitioner (GP) care compared with GP care alone, in patients with hip osteoarthritis (OA) during 12 months follow-up. " 01/01/2016 - "Effectiveness of exercise therapy added to general practitioner care in patients with hip osteoarthritis: a pragmatic randomized controlled trial." 01/01/2015 - "Thus, we did not find evidence to support our exercise therapy program to be an efficacious intervention to induce gait alterations in this population of hip osteoarthritis patients. "
5.	Osteotomy 07/01/2008 - "Periacetabular osteotomy is, on the average, more cost-effective in Tönnis grade-1 and grade-2 coxarthrosis, while it is both more costly and less effective in Tönnis grade-3 coxarthrosis. " 01/01/1998 - "Intertrochanteric varus osteotomy of the femur for hip osteoarthritis is expected to bring improved congruity and increased weight-bearing surface area of the hip joint. " 01/01/2011 - "In short, according to this study although the shelf acetabuloplasty is a salvage procedure and cannot cover the femoral head concentrically like the modern redirectional osteotomies , but it is an effective procedure for a young patient to postpone the progression of the hip osteoarthritis (OA) once it occurs in order to perform reconstructive surgeries later when justified." 07/01/2010 - "[The retrospective analysis of good and poor results of the intertrochanteric osteotomy for hip osteoarthritis]." 02/01/2010 - "Joint congruency in abduction before surgery as an indication for rotational acetabular osteotomy in early hip osteoarthritis."