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Infratentorial Neoplasms (Posterior Fossa Tumors)

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Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).

Also Known As:

Posterior Fossa Tumors; Benign Infratentorial Neoplasms; Infratentorial Cancer; Infratentorial Neoplasms, Benign; Infratentorial Neoplasms, Malignant; Malignant Infratentorial Neoplasms; Neoplasms, Infratentorial; Neoplasms, Posterior Fossa; Benign Infratentorial Neoplasm; Cancer, Infratentorial; Cancers, Infratentorial; Infratentorial Cancers; Infratentorial Neoplasm; Infratentorial Neoplasm, Benign; Infratentorial Neoplasm, Malignant; Infratentorial Tumor; Malignant Infratentorial Neoplasm; Neoplasm, Benign Infratentorial; Neoplasm, Infratentorial; Neoplasm, Malignant Infratentorial; Neoplasm, Posterior Fossa; Neoplasms, Benign Infratentorial; Neoplasms, Malignant Infratentorial; Posterior Fossa Neoplasm; Posterior Fossa Tumor; Tumor, Infratentorial; Tumor, Posterior Fossa; Tumors, Infratentorial; Tumors, Posterior Fossa; Infratentorial Tumors; Posterior Fossa Neoplasms

Networked: 102 relevant articles (5 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Hydrocephalus (Hydrocephaly)
3.	Meningomyelocele (Myelomeningocele)
4.	Meningitis
5.	Hypertension (High Blood Pressure)

Experts

1.	Alexiou, George A: 2 articles (04/2014 - 05/2008)
2.	Sainte-Rose, Christian: 2 articles (02/2013 - 11/2004)
3.	Padgett, Kyle R: 2 articles (12/2010 - 05/2008)
4.	Sandberg, David I: 2 articles (12/2010 - 05/2008)
5.	Gonzalez-Brito, Manuel: 2 articles (12/2010 - 05/2008)
6.	Kuluz, John W: 2 articles (12/2010 - 05/2008)
7.	Petito, Carol K: 2 articles (12/2010 - 05/2008)
8.	Solano, Juan: 2 articles (12/2010 - 05/2008)
9.	Crandall, Kenneth M: 2 articles (12/2010 - 05/2008)
10.	Gupta, Devendra Kumar: 1 article (02/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infratentorial Neoplasms:

1.	Protons (Proton)IBA 01/01/2001 - "[Clinical application of proton magnetic resonance spectroscopy for differential diagnosis of pediatric posterior fossa tumors]." 01/01/2001 - "Proton MRS of pediatric posterior fossa tumors seems to be helpful in prediction of tumor grading and histology. " 01/01/2001 - "We report here on a correlation between proton magnetic resonance spectroscopy (MRS) spectra obtained in children with posterior fossa tumors and tumor histology and grading. "
2.	cytidylyl-(3'-5')-cytidine (CpC)IBA 01/01/2007 - "Endoscopic third ventriculostomy (ETV) alone or with choroid plexus cauterization (CPC) is an emerging and very useful technique to manage hydrocephalus specially in children with: ventriculitis as a consequence of meningitis, myelomeningocele, obstructive hydrocephalus idiopathic or seconday to posterior fossa tumors. "
3.	Biogenic Amines (Biogenic Amine)IBA 04/01/2014 - "The aim of the present study was to investigate the role of biogenic amines in the ventricular CSF of children suffering from posterior fossa tumors and their possible correlation with tumor histology and cognitive functioning. "
4.	SugammadexIBA 07/01/2015 - "The present comparative and randomized study investigated the use of sugammadex for reversing profound neuromuscular blockade (NMB) in pediatric neurosurgical patients undergone posterior fossa tumor excision. " 07/01/2015 - "Forty pediatric patients undergoing elective craniotomy for posterior fossa tumor excision were randomly divided into either of neostigmine or sugammadex group in which muscle relaxant was reversed at the end of anesthesia either with neostigmine 0.04 mg/kg added to atropine 0.02 mg/kg or sugammadex 4 mg/kg alone, respectively. "
5.	AntigensIBA 01/01/2000 - "A patient with recurrent brainstem glioblastoma multiforme (GBM) received a series of three intradermal immunizations of antigen-pulsed DCs on an outpatient basis following surgical debulking of her posterior fossa tumor. " 05/01/1997 - "This report concerns two posterior fossa neoplasms, both of which displayed a "polyphenotypic" expression of neural, epithelial, myogenic, and glial markers, including synaptophysin, neurofilament, vimentin, glial fibrillary acidic protein, S-100, neuron-specific enolase, desmin, S antigen, MIC2, cytokeratin, epithelial membrane antigen, and carcinoembryonic antigen. "
6.	3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)IBA 09/01/2015 - "This report demonstrates that mild obstructive hydrocephalus due to a posterior fossa tumor may present with unexpected symptoms, such as CPP. " 05/01/2015 - "We herein report a sporadic case of posterior fossa tumor with synchronous choroid plexus papilloma (CPP) and ependymoma (EP) components. "
7.	Galectin 3 (LGALS3)IBA 02/01/2011 - "Galectin-3 expression: a useful tool in the differential diagnosis of posterior fossa tumors in children."
8.	Gadolinium DTPA (Magnevist)FDA Link 01/01/1993 - "Gadolinium-DTPA enhanced MRI is the modality of choice when imaging central nervous system infratentorial tumors in the pediatric population. "
9.	Mucin-1 (CA 15-3 Antigen)IBA 05/01/1997 - "This report concerns two posterior fossa neoplasms, both of which displayed a "polyphenotypic" expression of neural, epithelial, myogenic, and glial markers, including synaptophysin, neurofilament, vimentin, glial fibrillary acidic protein, S-100, neuron-specific enolase, desmin, S antigen, MIC2, cytokeratin, epithelial membrane antigen, and carcinoembryonic antigen. "
10.	SynaptophysinIBA 05/01/1997 - "This report concerns two posterior fossa neoplasms, both of which displayed a "polyphenotypic" expression of neural, epithelial, myogenic, and glial markers, including synaptophysin, neurofilament, vimentin, glial fibrillary acidic protein, S-100, neuron-specific enolase, desmin, S antigen, MIC2, cytokeratin, epithelial membrane antigen, and carcinoembryonic antigen. "

Therapies and Procedures

1.	Radiotherapy 01/01/2003 - "Late effects of radiotherapy on intellectual functioning have been well documented in children treated for posterior fossa tumors. " 01/01/1990 - "Moderate and severe disability was found in 48% of supra- and in 21% of infratentorial tumors, after radiotherapy (RT) in 55% vs. without RT in 18%. " 01/01/2009 - "Radiotherapy of the infratentorial tumors resulted in significantly improved survival in both univariate analysis (logrank P < 0.018) and multivariate analysis restricted to this tumor location (P = 0.033). " 05/01/1990 - "Twenty-one patients received postoperative radiotherapy, of whom six patients had supratentorial tumors and 15 had infratentorial tumors. " 02/01/2004 - "The outcome of such operations was improved by his recognition of the importance of tumor mural nodule in cyst recurrence, as well as elucidation of the histogenesis of pediatric posterior fossa tumors to tailor treatment including radiotherapy."
2.	Ventriculostomy 08/01/2003 - "We report an unsuccessful trial of third ventriculostomy in a case with huge posterior fossa tumor." 02/01/2013 - "Endoscopic third ventriculostomy and posterior fossa tumors." 01/01/2013 - "Preoperative endoscopic third ventriculostomy in children with posterior fossa tumors: an institution experience." 01/01/2012 - "The fact that less than one-third of patients require a CSF diversion after posterior fossa tumor resection refutes the role of prophylactic endoscopic third ventriculostomy. " 10/01/2009 - "Reverse herniation of brain: a less recognized complication in a patient with midline posterior fossa tumor postendoscopic third ventriculostomy."
3.	Decompression 12/01/1981 - "The best current treatment (aside from removing an etiologic lesion such as a posterior fossa tumor in the small percentage of cases with such lesions) is microvascular decompression of the facial nerve at the pons through a retromastoid craniectomy. " 12/01/1988 - "The following applications are illustrated and discussed: 1) intraoperative monitoring of auditory function during posterior fossa tumor resection, 2) auditory brain stem response and VIIIth nerve monitoring during retrolabyrinthine vestibular nerve section, 3) monitoring of auditory function during microvascular decompression of cranial nerve VII, VIII, or IX, and 4) special applications related to cochlear implant surgery." 10/01/2006 - "To date, multiple reports have supported the impression that a small subpopulation of patients with posterior fossa tumors can present with arterial hypertension, and many of those patients achieved significant improvement of their hypertension after tumor resection and medullary decompression. "
4.	Drug Therapy (Chemotherapy) 12/01/2006 - "This study examined the effects of posterior fossa tumor surgery and concomitant irradiation and/or chemotherapy on the long-term recovery of balance function in children and adolescent patients. " 04/01/2009 - "Seventeen patients were treated: previous treatment included CSI of 19.5-36 Gy with posterior fossa/tumor boost and chemotherapy in 16 patients. " 05/01/2008 - "The authors hypothesized that chemotherapy infusions directly into the fourth ventricle may potentially play a role in treating malignant posterior fossa tumors. " 05/01/2003 - "Twenty-two patients with an institutional diagnosis high-grade posterior fossa tumors received chemotherapy and/or irradiation. " 03/01/2000 - "Supratentorial and infratentorial tumors had a good response to chemotherapy. "
5.	Ventriculoperitoneal Shunt 03/01/1994 - "An analysis of factors determining the need for ventriculoperitoneal shunts after posterior fossa tumor surgery in children." 01/01/2009 - "Intratumoral hemorrhage is a rare but important cause of morbidity and mortality in patients with posterior fossa tumors who undergo ventriculoperitoneal shunt." 01/01/2009 - "We report on two patients with rare major intratumoral hemorrhage following ventriculoperitoneal shunt in posterior fossa tumors. " 01/01/2009 - "Fatal intratumoral hemorrhage in posterior fossa tumors following ventriculoperitoneal shunt." 03/01/2004 - "Ventriculoperitoneal shunts were routinely used in the past in children with posterior fossa tumors and hydrocephalus. "