Epidural Neoplasms

Neoplasms located in the space between the vertebral PERIOSTEUM and DURA MATER surrounding the SPINAL CORD. Tumors in this location are most often metastatic in origin and may cause neurologic deficits by mass effect on the spinal cord or nerve roots or by interfering with blood supply to the spinal cord.

Also Known As:

Networked: 47 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Spinal Cord Compression
2.	Neoplasms (Cancer)
3.	Pain (Aches)
4.	Sclerosis
5.	Hodgkin Disease (Hodgkin's Disease)

Experts

1.	Bannwarth, M: 1 article (12/2015)
2.	Eap, C: 1 article (12/2015)
3.	Litre, C-F: 1 article (12/2015)
4.	Theret, É: 1 article (12/2015)
5.	Jazeron, J-F: 1 article (12/2015)
6.	Duntze, J: 1 article (12/2015)
7.	Kleber, J-C: 1 article (12/2015)
8.	Bilsky, Mark: 1 article (10/2015)
9.	Laufer, Ilya: 1 article (10/2015)
10.	Lee, Chang-Hyun: 1 article (05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Epidural Neoplasms:

1.	InterferonsIBA 01/01/2008 - "This 20 years old male patient with a history of Hodgkin's disease since 1996, stage II variety nodular sclerosis, was initially managed with radiotherapy and chemotherapy ending such treatment in January 1997, subsequently treated with interferon for one year, ending in January 1998, presented complete remission and was maintained in observation; in June 1999 started with thoracolumbar pain, weakness and diminished sensitivity on lower limbs, studies were conducted and diagnosed epidural tumor from levels T9 to T12, with important spinal cord compression; the patient was submitted to surgery and neurological recovery was complete."
2.	Gadolinium DTPA (Magnevist)FDA Link 04/01/1988 - "Gd-DTPA MR images were helpful in differentiating disk herniation from epidural tumors, indicating regions of more active tumor for biopsy, outlining areas of spinal cord compression, and demonstrating tumor response to therapy. "
3.	Dexamethasone (Maxidex)FDA LinkGeneric 06/01/1989 - "A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor."
4.	Immunoglobulin D (IgD)IBA 09/01/1992 - "Extraosseous epidural tumor of immunoglobulin D myeloma." 12/01/2000 - "In IgD myeloma, extraosseous spreads occur frequently, but extraosseous epidural tumors causing compression myelopathy are relatively rare. "
5.	Keratin-20 (Cytokeratin 20)IBA 09/01/2008 - "Histopathology of the epidural tumor was consistent with MCC and the diagnosis was confirmed by immuno-histochemistry staining for cytokeratin-20. "
6.	Excitatory Amino Acid AntagonistsIBA 06/01/1990 - "It has been demonstrated in paraplegic rats harboring an epidural neoplasm that an antiedema effect can be achieved by in vivo treatment with either steroidal or nonsteroidal anti-inflammatory agents or by glutamate receptor antagonists. "
7.	N-Methylaspartate (NMDA)IBA 06/01/1990 - "We studied the in vivo effect of two selective N-methyl-D-aspartate receptor antagonists on the compressed spinal cord segments of rats harboring a thoracolumbar epidural tumor. "
8.	Serotonin (5 Hydroxytryptamine)IBA 04/01/1991 - "We evaluated the role of serotonin (5-HT) in neoplastic cord compression in paraplegic rats harboring a thoracolumbar epidural tumor. "
9.	Phenobarbital (Luminal)FDA Link 04/01/1994 - "Paraplegic rats harboring a thoracolumbar epidural tumor, or an identical hindlimb tumor mass, received an i.v. infusion of phenobarbital until the onset of anesthesia. "
10.	MetrizamideFDA Link 05/01/1988 - "Epidural tumor was demonstrated by CT metrizamide myelography in four cases, all correctly identified by MR. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/1991 - "Often, the epidural tumor in a child is identified before significant spinal canal compromise has occurred, and these children frequently can be managed by radiation therapy and/or chemotherapy. " 02/01/1984 - "Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor." 12/01/1993 - "After resecting the epidural tumor of thoracic spine, chemotherapy (CAV 1 kur) and radiotherapy (4,200 rad) was performed which was effective for minimizing the antero-mediastinal tumor. " 03/01/1993 - "The potential of this approach in treating patients with epidural tumors and other neoplasms, especially those that are not sensitive to chemotherapy or radiotherapy, deserves to be explored." 04/01/2012 - "Most cases are due to epidural tumor metastases with resulting cord compression, although intramedullary spinal cord metastases, radiation myelopathy, and myelopathic complications of chemotherapy must be considered. "
2.	Radiotherapy 10/01/1986 - "From December 1981 through August 1984, 24 patients with spinal cord compression syndrome due to epidural neoplasms were evaluated for radiotherapy with clinical examination, radiographs of the spine, and myelography. " 12/01/1993 - "After resecting the epidural tumor of thoracic spine, chemotherapy (CAV 1 kur) and radiotherapy (4,200 rad) was performed which was effective for minimizing the antero-mediastinal tumor. " 03/01/1993 - "The potential of this approach in treating patients with epidural tumors and other neoplasms, especially those that are not sensitive to chemotherapy or radiotherapy, deserves to be explored." 01/01/2008 - "This 20 years old male patient with a history of Hodgkin's disease since 1996, stage II variety nodular sclerosis, was initially managed with radiotherapy and chemotherapy ending such treatment in January 1997, subsequently treated with interferon for one year, ending in January 1998, presented complete remission and was maintained in observation; in June 1999 started with thoracolumbar pain, weakness and diminished sensitivity on lower limbs, studies were conducted and diagnosed epidural tumor from levels T9 to T12, with important spinal cord compression; the patient was submitted to surgery and neurological recovery was complete."
3.	Decompression 08/01/1999 - "The patient improved rapidly after surgical resection of the epidural tumor and decompression of the cord. " 05/01/2010 - "This study demonstrated a radiosurgical decompression of epidural tumor. " 06/01/2011 - "The authors conducted a retrospective review of 45 cases of metastatic spine disease with epidural tumor extension in which patients underwent circumferential decompression and fusion by means of PTA. " 05/01/2010 - "Primary endpoints were epidural tumor control and thecal sac decompression. " 02/01/2010 - "Surgical resection of the epidural tumor for decompression was performed. "
4.	Surgical Decompression 04/01/2012 - "Techniques for surgical decompression of the spinal cord in patients with epidural tumor have improved significantly over the past decade. " 09/01/1985 - "Surgical decompression of anterior and posterior malignant epidural tumors compressing the spinal cord: a prospective study." 01/01/1977 - "Surgical decompression for spinal cord compression secondary to metastatic epidural neoplasms is a common procedure. "
5.	Combination Drug Therapy (Combination Chemotherapy) 09/01/1992 - "A complete remission was obtained after combination chemotherapy, but the patient died from an epidural tumor in the high thoracic region 19 months after the onset of symptoms."