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8,11,14-Eicosatrienoic Acid (DHLA)

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A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.

Also Known As:

DHLA; Dihomo-gamma-Linolenic Acid; 8,11,14 Eicosatrienoic Acid; Acid, Dihomo-gamma-Linolenic; Dihomogammalinolenic Acid; Ro 12-1989; Acid, Dihomogammalinolenic; Acid, Homo-gamma Linolenic; Dihomo gamma Linolenic Acid; Homo gamma Linolenic Acid; Linolenic Acid, Homo-gamma; Ro 12 1989; Ro 121989; Homo-gamma Linolenic Acid; 8,11,14-Eicosatrienoic acid

Networked: 96 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 18571
- Fatty Acids: 6864
  - Unsaturated Fatty Acids: 3881
    - Eicosanoids: 1470
      - 8,11,14-Eicosatrienoic Acid: 96
        11,12-epoxy-5,8,14-eicosatrienoic acid: 28
        14,15-epoxy-5,8,11-eicosatrienoic acid: 22
        8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid: 14
        mead acid: 14
        5,6-epoxy-8,11,14-eicosatrienoic acid: 5
        8,9-epoxyeicosatrienoic acid: 5
        14,15-dihydroxyeicosatrienoic acid: 4
        10-hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acid: 1
        12-hydroxy-5,8,14-eicosatrienoic acid: 1
        14,15-eicosa-5-enoic acid: 1
        10,11,12-trihydroxyeicosatrienoic acid
        10-hydroxy-11,12-cyclopropyleicosa-5,8,14-trienoic acid methyl ester
        11,12,15-trihydroxyeicosatrienoic acid
        11,12-dihydroxy-5,8,14-eicosatrienoic acid
        11,12-dihydroxyeicosatrienoic acid
        11,12-epoxyeicosatrienoic acid methyl ester
        11,12-thiiranohepoxilin A3
        11,14,15-trihydroxyeicosa-5,8,12-trienoic acid
        11,14,17-eicosatrienoic acid
        11-glutathionylhepoxilin A3
        11-hydroxy-8,12,14-eicosatrienoic acid
        11-hydroxy-8,9-epoxyeicosatrienoic acid
        13-hydroxy-14,15-epoxyeicosa-5,8,11-trienoic acid
        14,14-epoxyeicosa-5-enoic methylsulfonylimide
        14,15-dihydroxy-5,8,11-eicosatrienoic acid
        14,15-episulfide eicosatrienoic acid
        14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid
        15-hydroxy-11,12-epoxyeicosatrienoic acid
        15-hydroxy-5,8,11-eicosatrienoic acid
        15-hydroxy-8,11,13-eicosatrienoic acid
        16-hydroxyheneicosatrienoic acid
        2-methyl-8,12,14-eicosatrienoic acid
        20-iodo-14,15-epoxyeicosa-5-enoic acid
        5,12,20-trihydroxy-6,8,14-eicosatrienoic acid
        5,12,20-trihydroxy-8,10,14-eicosatrienoic acid
        5,6-dihydroxy-8,11,14-eicosatrienoic acid
        5,8,14-eicosatrienoic acid
        8,11,12-trihydroxy-5,9,14-eicosatrienoic acid
        8-hydroxy-11,12-cyclopropyleicosa-5,9,14-trienoic acid methyl ester
        eicosa-8,11,14-trien-5-ynoic acid
        ethyl dihomo-gamma-linolenate
        hepoxillin A3-D
        mead ethanolamide
        methyl branched 8,11,14-eicosatrienoic acid
        PBT-3 compound
        tridihomo-gamma-linolenoylglycerol

Experts

1.	Hornstra, Gerard: 3 articles (01/2013 - 02/2009)
2.	Wang, Ying-Jan: 3 articles (03/2011 - 06/2007)
3.	Das, Undurti N: 2 articles (01/2011 - 01/2008)
4.	Kester, Arnold D: 2 articles (08/2009 - 02/2009)
5.	Dirix, Chantal E H: 2 articles (08/2009 - 02/2009)
6.	Florido, Jesús: 1 article (08/2015)
7.	Uhl, Olaf: 1 article (08/2015)
8.	Koletzko, Berthold: 1 article (08/2015)
9.	Rueda, Ricardo: 1 article (08/2015)
10.	Segura, María Teresa: 1 article (08/2015)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 02/01/2014 - "Therefore, this study investigated whether EPO supplementation results in an increase in plasma GLA and its metabolite dihomo-gamma-linolenic acid (DGLA) correlating with clinical improvement of AD, assessed by the SCORing Atopic Dermatitis (SCORAD) index. " 01/01/2008 - "Oral administration of dihomo-gamma-linolenic acid prevents development of atopic dermatitis in NC/Nga mice." 07/01/2010 - "Administration of dihomo-gamma-linolenic acid is useful for atopic dermatitis and atherosclerosis in mice; however, the metabolites of dihomo-gamma-linolenic acid have been little studied. " 11/01/1989 - "Results show that mothers of children with atopic eczema have a significantly greater proportion of linoleic acid, and a smaller proportion of dihomo-gamma-linolenic acid in their total breast milk lipid than the controls. " 07/01/2005 - "Plasma levels of linoleic acid (LA), gammalinolenic acid (GLA), dihomogammalinolenic acid (DGLA) and arachidonic acid (AA) were measured using HPLC in 22 children with atopic dermatitis. "
2.	Coronary Disease (Coronary Heart Disease) 08/15/1995 - "These results suggest that: (1) DHLA may be more effective in inhibiting PAg than EPA, which has been reported to reduce the incidence of coronary diseases in some human populations; (2) That superoxide radical may activate the platelet cyclooxygenase system to increase lipid peroxidation of these PUFA prostanoid precursors and may result in the inhibition of PAg, whereas H2O2 may have an opposite effect." 02/01/1996 - "Our results indicate that three nonessential fatty acids--stearic acid, palmitoleic acid, and omega 9 eicosatrienoic acid, and one essential fatty acid--dihomogammalinolenic acid, are independent correlates of blood pressure among middle-aged American men at high risk of coronary heart disease."
3.	Leprosy (Hansen's Disease) 06/01/1985 - "A significant reduction in linoleic acid was found in the leprosy patients, with an increase in its metabolite dihomo-gamma-linolenic acid. "
4.	Granuloma 05/27/1986 - "As prostaglandin E1 has been shown to be more effective in inhibiting granuloma growth than prostaglandin E2 we investigated the effect of linoleic acid (LA) (18:2 omega 6) and dihomo-gamma-linolenic acid (DHGLA) (20:3 omega 6), potential precursors of prostaglandin E1, in this model. "
5.	Neoplasms (Cancer) 12/01/2008 - "Nonetheless, the detailed mechanisms of DHLA in attenuating TCHQ-induced skin tumor promotion are still unclear and need to be further investigated. " 01/01/2008 - "GLAO increased serum concentration of GLA but had no significant effect on tumor GLA or dihomo-gamma linolenic acid (DGLA) concentrations. " 12/01/2008 - "In the present study, we further examined the effects of DHLA on DMBA/TCHQ-induced skin tumor formation and the possible mechanisms. " 12/01/2008 - "We found that DHLA significantly inhibited tumor incidence and tumor multiplicity in DMBA/TCHQ-induced skin tumor formation. " 12/01/2008 - "We recently reported that DHLA can inhibit DMBA/TPA-induced skin tumor formation through its anti-inflammatory and anti-oxidizing functions. "

Related Drugs and Biologics

1.	Linoleic Acid (Linoleate)
2.	Dinoprostone (PGE2)
3.	Alprostadil (Muse)
4.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
5.	Superoxides (Superoxide)
6.	8,11,14-Eicosatrienoic Acid (DHLA)
7.	Arachidonic Acid (Vitamin F)
8.	Prostaglandins
9.	dihydrolipoic acid
10.	Thioctic Acid (Lipoic Acid)

Related Therapies and Procedures

1.	Chemoprevention
2.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
3.	Injections
4.	Oral Administration