8-Bromo Cyclic Adenosine Monophosphate (8 Bromo Cyclic Adenosine Monophosphate)

A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.

Also Known As:

8 Bromo Cyclic Adenosine Monophosphate; 8-Br Cyclic AMP; 8-Bromo Cyclic AMP; 8-Bromo Cyclic Adenosine Monophosphate, Monosodium Salt; 8-Bromo Cyclic Adenosine Monophosphate, Sodium Salt; 8-Bromoadenosine 3',5'-Cyclic Monophosphate; Br Cycl AMP; 8 Br Cyclic AMP; 8 Bromo Cyclic AMP; 8 Bromo Cyclic Adenosine Monophosphate, Monosodium Salt; 8 Bromo Cyclic Adenosine Monophosphate, Sodium Salt; 8 Bromo cAMP; 8 Bromoadenosine 3',5' Cyclic Monophosphate; AMP, Br Cycl; Cyclic AMP, 8-Br; Cyclic AMP, 8-Bromo; 8-Bromo-cAMP; Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate)

Networked: 94 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Baoxue: 2 articles (01/2021 - 12/2016)
2.	Zhou, Hong: 2 articles (01/2021 - 12/2016)
3.	Geng, Xiaoqiang: 1 article (01/2021)
4.	He, Jinzhao: 1 article (01/2021)
5.	Huang, Huihui: 1 article (01/2021)
6.	Jenny Lu, Hua A: 1 article (01/2021)
7.	Jia, Yingli: 1 article (01/2021)
8.	Jin, William: 1 article (01/2021)
9.	Li, Min: 1 article (01/2021)
10.	Li, Xiaowei: 1 article (01/2021)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2010 - "We also found that nociceptive responses induced by TIP39- or the cAMP analog 8-bromo-cAMP were significantly greater following partial sciatic nerve injury induced neuropathic pain, without changes in PTH2 receptor expression. "
2.	Bacterial Infections (Bacterial Infection) 01/01/2018 - "Accordingly, ADP-induced MCP-1 production and protection against bacterial infection could also be reduced by U0126, forskolin and 8-bromo-cAMP. "
3.	Cysts 01/01/2022 - "MOC has been previously used to study polycystic kidney disease as treatment with 8-bromo-cAMP induces the formation of kidney cysts. " 12/01/2016 - "With stimulation of 8-bromo-cAMP, RGMb-null embryonic kidneys had greater cyst index, though their ureteric bud branched less than wild-type mice at E13.5. Postnatal RGMb-null kidneys showed interstitial hyperplasia and decreased tubular structures, especially in the boundary area of renal cortex and medulla. " 01/01/2021 - "We established the forskolin (FSK)-induced three-dimensional (3D) Madin-Darby Canine Kidney cystogenesis model and 8-bromoadenosine-3`,5`-cyclic monophosphate-stimulated cyst formation in ex vivo embryonic kidney culture. " 08/01/1989 - "MDCK cells, cultured in hydrated-collagen gel, produced polarized monolayered epithelial cysts when intracellular cAMP was increased by prostaglandin E1, arginine vasopressin, cholera toxin, forskolin, or 8-bromoadenosine 3',5'-cyclic monophosphate. "
4.	Ovarian Neoplasms (Ovarian Cancer) 02/01/2002 - "HEY cells, an ovarian cancer cell line which expresses c-KIT and KL, were treated with dibutyryl cyclic AMP (dbcAMP), 8-bromo-cAMP, and cholera toxin over a range of concentrations. " 01/01/2003 - "In the present study, expression and regulation of hCG receptor mRNA were analyzed in four established human ovarian cancer cell lines using different concentrations of hCG, EGF, and 8-bromo-cAMP for different periods between 6 and 72 h. "
5.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 02/06/1995 - "The mechanism of ectopic adrenocorticotrophic hormone (ACTH) secretion was examined by studies on the effects of corticotropin-releasing hormone (CRH), dexamethasone, interleukin (IL)-1 beta and 2, somatostatin, calcium ionophore A23187, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 8-bromo-cAMP on pro-opiomelanocortin (POMC) expression and ACTH secretion from a human small cell lung cancer cell line COR-L103. "

Related Drugs and Biologics

1.	Colforsin
2.	Adenosine Diphosphate (ADP)
3.	Type 2 Parathyroid Hormone Receptor
4.	U 0126 (UO 126)
5.	Messenger RNA (mRNA)
6.	Calcium Ionophores
7.	Adrenocorticotropic Hormone (ACTH)
8.	Calcimycin (A23187)
9.	Somatostatin (Somatotropin Release-Inhibiting Factor)
10.	Brain-Derived Neurotrophic Factor (BDNF)

Related Therapies and Procedures

1.	Punctures
2.	Intra-Arterial Injections