Androstenediol

An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).

Also Known As:

5-Androstene-3,17-diol; 5-Androstene-3beta-17beta-Diol; Androst-5-ene-3 beta,17 beta-Diol; Androst-5-ene-3,17-diol; Bisexovister; Delta 5-Androstenediol; Hermaphrodiol; delta 5-Androstene-3 beta,17 beta-Diol; 5 Androstene 3,17 diol; 5 Androstene 3beta 17beta Diol; Androst 5 ene 3 beta,17 beta Diol; Androst 5 ene 3,17 diol; Delta 5 Androstenediol; delta 5 Androstene 3 beta,17 beta Diol; Androst-5-ene-3,17-diol, (3beta,17beta)-

Networked: 92 relevant articles (7 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chaudry, Irshad H: 7 articles (03/2007 - 08/2004)
2.	Shimizu, Tomoharu: 7 articles (03/2007 - 08/2004)
3.	Bland, Kirby I: 6 articles (08/2006 - 08/2004)
4.	Choudhry, Mashkoor A: 6 articles (08/2006 - 08/2004)
5.	Loria, R M: 5 articles (09/2000 - 01/2000)
6.	Szalay, Laszlo: 4 articles (04/2006 - 08/2004)
7.	Namiki, Mikio: 3 articles (04/2010 - 01/2004)
8.	Hsieh, Ya-Ching: 3 articles (08/2006 - 08/2005)
9.	Suzuki, Takao: 3 articles (08/2006 - 04/2006)
10.	Rue, Loring W: 3 articles (04/2006 - 08/2004)

Related Diseases

1.	Infections 01/01/2000 - "Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice." 06/23/1993 - "Androstenediol regulates systemic resistance against lethal infections in mice." 01/01/1992 - "Androstenediol regulates systemic resistance against lethal infections in mice." 09/01/1996 - "We have previously reported that androstenediol (5-androstene-3 beta, 17 beta-diol, AED), derived from DHEA, is at least 100 x more effective in up-regulating systemic resistance against CB4 infection than its precursor. " 01/01/1992 - "Androstenediol (5-androsten-3 beta-17 beta-diol, AED), a metabolic product of DHEA is up to 100 x more effective in regulating systemic resistance against lethal infection with CB 4 than its precursor DHEA. "
2.	Wounds and Injuries (Trauma) 08/01/2011 - "Androstenediol represents a potential therapeutic agent after major trauma in high-risk patients." 08/01/2005 - "A recent study suggested that administration of androstenediol (Adiol) after trauma-hemorrhage (T-H) improves hepatic functions; however, the mechanism responsible for the salutary effect of Adiol remains unknown. " 07/01/2006 - "To examine the mechanism by which androstenediol improves cardiac function following trauma-hemorrhage (T-H). " 08/01/2004 - "Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage." 08/01/2011 - "The specific effect of androstenediol on chemokines after trauma is unknown. "
3.	Hemorrhage 08/01/2011 - "Traumatic hemorrhage was induced followed by androstenediol application and volume resuscitation. " 08/01/2005 - "A recent study suggested that administration of androstenediol (Adiol) after trauma-hemorrhage (T-H) improves hepatic functions; however, the mechanism responsible for the salutary effect of Adiol remains unknown. " 07/01/2006 - "To examine the mechanism by which androstenediol improves cardiac function following trauma-hemorrhage (T-H). " 08/01/2004 - "Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage." 08/01/2006 - "Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis."
4.	Sepsis (Septicemia) 04/01/2006 - "Furthermore, survival rate following T-H and subsequent sepsis was improved by androstenediol treatment. " 03/01/2014 - "Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis." 04/01/2006 - "Since androstenediol administration following T-H attenuated cytokine production and reduced mortality in a double-hit model of T-H and sepsis, this agent appears to be a novel and useful adjunct for maintaining the immune cell functions following T-H and for decreasing the mortality rate from subsequent susceptibility to sepsis." 08/01/2006 - "Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis." 08/01/2006 - "Although androstenediol (adiol or 5-androstene-3beta,17beta-diol), a metabolite of dehydroepiandrosterone (DHEA), has protective effects following trauma-hemorrhage (T-H), it remains unknown whether administration of adiol has any salutary effects on the inflammatory response and outcome following a combined insult of T-H and sepsis. "
5.	Encephalitis (Encephalitis, Rasmussen) 08/14/1998 - "Increased levels of IFN-gamma in the trigeminal ganglion correlate with protection against HSV-1-induced encephalitis following subcutaneous administration with androstenediol." 03/15/1998 - "Androstenediol antagonizes herpes simplex virus type 1-induced encephalitis through the augmentation of type I IFN production." 03/15/1998 - "Dehydroepiandrosterone and androstenediol (AED) have previously been found to protect mice from viral-induced encephalitis resulting in an increased survival rate of the animals. "

Related Drugs and Biologics

1.	Dehydroepiandrosterone (DHEA)
2.	Hormones (Hormone)
3.	Cytokines
4.	cyclosporine metabolite M17
5.	Androgens
6.	Estradiol (Delestrogen)
7.	Estrogens (Estrogen)
8.	Antigens
9.	Anastrozole (Arimidex)
10.	Testosterone (Sustanon)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation
3.	Intravenous Administration
4.	Punctures
5.	Orchiectomy (Orchidectomy)