4-Hydroxyaminoquinoline-1-oxide (4 Hydroxyaminoquinoline 1 oxide)

A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.

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Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Necrosis 04/01/1989 - "Morphological, biochemical and autoradiographic studies of pancreatic acinar cell necrosis and its regeneration induced by 4-hydroxyaminoquinoline-1-oxide in rats." 04/01/1989 - "A single intravenous injection of 4-hydroxyaminoquinoline-1-oxide (4-HAQO) induced a dose-dependent diffuse pancreatic acinar cell necrosis within 48 hours after the administration in rats. " 01/01/1975 - "A single intravenous injection of 4-hydroxyaminoquinoline-1-oxide, in a dose of 22.5 mg. per kg., induced marked necrosis of exocrine pancreas in inbred strain 13 guinea pigs within 48 hours. "
2.	Carcinogenesis 11/01/1977 - "The effect of 4-hydroxyaminoquinoline-1-oxide (4-HAQO) on DNA synthesis in the pancreas and liver, target and non-target organs for 4-HAQO carcinogenesis, respectively, were compared. "
3.	Acute Necrotizing Pancreatitis 01/01/1975 - "Pancreatic necrosis and regeneration induced by 4-hydroxyaminoquinoline-1-oxide in the guinea pig."
4.	Hepatocellular Carcinoma (Hepatoma) 08/01/1966 - "3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas."
5.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1992 - "A more than additive enhancement of the frequency of chromosome aberrations was also noted in HCMV-infected PBLs exposed to 4-hydroxyaminoquinoline-1-oxide (4-HAQO; 0.1 to 0.3 micrograms/ml) relative to uninfected cells treated with 4-HAQO alone. "

Related Drugs and Biologics

1.	4-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)
2.	Enzymes
3.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Intravenous Injections