2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T)

An herbicide with strong irritant properties. Use of this compound on rice fields, orchards, sugarcane, rangeland, and other noncrop sites was terminated by the EPA in 1985. (From Merck Index, 11th ed)

Also Known As:

Networked: 43 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sandler, Dale P: 2 articles (06/2020 - 10/2013)
2.	Alavanja, Michael C: 1 article (06/2020)
3.	Beane Freeman, Laura E: 1 article (06/2020)
4.	Blair, Aaron: 1 article (06/2020)
5.	Engel, Lawrence S: 1 article (06/2020)
6.	Koutros, Stella: 1 article (06/2020)
7.	Lerro, Catherine C: 1 article (06/2020)
8.	Satagopan, Jaya: 1 article (06/2020)
9.	Werder, Emily J: 1 article (06/2020)
10.	Goldner, Whitney S: 1 article (10/2013)

Related Diseases

1.	Ulcer 08/01/1983 - "Among the cohort of employees potentially exposed during the manufacture of 2,4,5-trichlorophenoxyacetic acid (2,4,5,-T), a significantly greater frequency of x-ray proved ulcer was reported and significantly more members of this group had diseases of the digestive system diagnosed. "
2.	Neoplasms (Cancer) 02/01/2007 - "The results do not suggest an increased cancer risk among the New Plymouth population related to the period of 2,4,5-T manufacture, although the study's limitations mean the possibility of an undetectable small elevation in cancer risk cannot be excluded. " 04/23/1980 - "2,4,5-T and cancer." 02/01/2007 - "Although TCDD exposure in the first few years of 2,4,5-T manufacture may have contributed to cancer incidence in 1970-74, unknown exposure(s) before the start of 2,4,5-T manufacture and chance are also possible explanations." 02/01/2007 - "Cancer incidence and mortality in a New Zealand community potentially exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin from 2,4,5-trichlorophenoxyacetic acid manufacture." 05/01/2002 - "Having received blood products other than a transfusion (OR=9.1, 95%CI 2.2-37.4) and exposure to a pesticide containing 2,4,5-T (OR=5.9, 95%CI 1.5-23.7) were related to sinonasal cancer only. "
3.	Sarcoma (Soft Tissue Sarcoma) 10/01/1984 - "In addition three individuals who worked for companies which made 2,4,5-T also have confirmed soft tissue sarcomas. " 01/31/1981 - "2,4,5-T, trichlorophenol, and soft tissue sarcoma." 10/01/1984 - "A review of employment records and tissue specimens of seven workers, reported previously as having occupational dioxin exposure and soft tissue sarcomas, confirms that four workers had employment of 2 to 19 years in the production of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) or trichlorophenol, products contaminated with 2,3,7,8-tetrachlorodibenzodioxin, the most toxic dioxin isomer. " 02/01/2007 - "To investigate whether the rates of all cancers and four cancers (soft tissue sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease and chronic lymphocytic leukaemia) associated with dioxin exposure are higher in New Plymouth, the site of a former 2,4,5-T manufacturing plant, than for the rest of New Zealand. " 10/01/1986 - "The findings do not exclude the possibility that MCPA is a human carcinogen, but they suggest that any risk of soft tissue sarcoma is less than that indicated by earlier studies of 2,4,5-T (2,4,5-trichlorophenoxyacetic acid) and 2,4,5-trichlorophenol and is small in absolute terms."
4.	Cleft Palate (Palate, Cleft) 06/01/1979 - "Retrospective study of the relationship between agricultural use of 2,4,5-T and cleft palate occurrence in Arkansas." 01/01/1979 - "Although low incidences were seen in all treatment groups, only 2,4,5-T significantly increased cleft palate or other gross malformations. " 08/01/1992 - "Reduced fetal weight and increased incidence of cleft palate and embryolethality were the most significant prenatal effects of 2,4,5-T exposure observed in this study. " 08/01/1992 - "There were no embryotoxic or fetotoxic differences between the technical and analytical grades of 2,4,5-T with regard to extent of fetal weight reduction, resorption rate, or cleft palate incidence. " 08/01/1992 - "Reduced fetal weight and increased incidences of cleft palate and embryolethality were the most significant prenatal effects of both formulations of 2,4,5-T observed in all strains/stocks of mice. "
5.	Fetal Weight 08/01/1992 - "Reduced fetal weight and increased incidence of cleft palate and embryolethality were the most significant prenatal effects of 2,4,5-T exposure observed in this study. " 08/01/1992 - "There were no embryotoxic or fetotoxic differences between the technical and analytical grades of 2,4,5-T with regard to extent of fetal weight reduction, resorption rate, or cleft palate incidence. " 08/01/1992 - "Reduced fetal weight and increased incidences of cleft palate and embryolethality were the most significant prenatal effects of both formulations of 2,4,5-T observed in all strains/stocks of mice. " 01/01/1979 - "With the exception of 2,4,5-trichlorophenol treatment on day 14, only 2,4,5-T treatment significantly increased prenatal mortality, and only 2,4,5-T was associated with decreased fetal weight when comparisons were made with the solvent controls. "

Related Drugs and Biologics

1.	Herbicides
2.	2,4-Dichlorophenoxyacetic Acid (2,4 Dichlorophenoxyacetic Acid)
3.	Dioxins
4.	Carcinogens
5.	Hexachlorocyclohexane (gamma-Hexachlorocyclohexane)
6.	Acids
7.	2,4,5-trichlorophenol
8.	Toxaphene
9.	Organophosphates
10.	Methoxychlor (Metox)