HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2-Aminopurine (2 Aminopurine)

A purine that is an isomer of ADENINE (6-aminopurine).

Also Known As:

2 Aminopurine; 1H-Purin-2-amine

Networked: 31 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Du, Jintong: 1 article (01/2022)
2.	Fang, Hao: 1 article (01/2022)
3.	Hou, Xuben: 1 article (01/2022)
4.	Liang, Hanzhi: 1 article (01/2022)
5.	Yang, Xinying: 1 article (01/2022)
6.	Zhao, Zhiyuan: 1 article (01/2022)
7.	Zhu, Yue: 1 article (01/2022)
8.	Guan, X D: 1 article (04/2020)
9.	Mei, M H: 1 article (04/2020)
10.	Ouyang, B: 1 article (04/2020)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2009 - "A significant improvement in viral replication and the antitumor effect was observed when the PKR inhibitor 2-aminopurine was coadministered with HSV-G47Delta to the tumor. " 01/01/1985 - "2-Aminopurine is much less potent than 6-N-hydroxylaminopurine in inducing gene mutation in mammalian cells in culture and this corresponds to the relative activity of these two compounds in inducing tumors in rats and neoplastic transformation of Syrian hamster embryo cells in culture. " 02/01/1975 - "cis-Platinum (II)diamminodichloride (PDD), an anti-tumor agent, induced auxotrophic mutations in Escherichia coli, some of which were reverted to prototrophy by exposure to PDD, 2-aminopurine (2-AP), and N-methyl-N'-nitro-N-mitrosoguanidine (NTG), but not ICR derivatives. " 05/15/1999 - "To assess the possibility that selected purine analogues may affect tumor neovascularization, 6-methylmercaptopurine riboside (6-MMPR), 6-methylmercaptopurine, 2-aminopurine, and adenosine were evaluated for the capacity to inhibit angiogenesis in vitro and in vivo. "
2.	Glioma (Gliomas) 01/13/1992 - "In the present study, 2-aminopurine, which has been reported to selectively block c-fos gene expression, was used to test the hypothesis that c-fos protein might be involved in the desensitization to catecholamines was observed in 2-aminopurine-treated C6-2B rat glioma cells. " 01/13/1992 - "2-Aminopurine inhibits RNA and protein synthesis and reduces catecholamine desensitization in C6-2B rat glioma cells."
3.	Infections 09/01/2019 - "Before infection with Reo3 for 48 h, HL60 cells were treated with 2-aminopurine (2-AP), a specific inhibitor of PKR, for 24 h. " 01/01/1982 - "The survival of UV-irradiated lambda phages is increased when host bacteria are grown in the presence of the base analogue 2-aminopurine (2AP) before infection. " 01/01/2002 - "Lipopolysaccharide-induced impairment of classical swine fever virus infection in monocytic cells is sensitive to 2-aminopurine." 05/01/2009 - "Inhibition of RNA-activated protein kinase (PKR) by 2-aminopurine completely abolished both BAFF mRNA and protein production after reovirus-1 infection and poly(I:C) stimulation through NF-kappaB and p38 MAPK pathways, with the latter implicated only after poly(I:C) stimulation. "
4.	Ganglion Cysts (Ganglion) 08/01/1997 - "The protein kinase inhibitor 2-aminopurine (2-AP, 10 mM) prevented apoptosis of axotomized ganglion cells and induced apoptosis in the NBL. " 10/01/2006 - "We have previously shown that anisomycin, a protein synthesis inhibitor, and 2-aminopurine, a specific inhibitor of the double stranded-RNA dependent protein kinase, block apoptosis of ganglion cells induced by axotomy, and induce apoptosis of cells in the neuroblastic layer in developing rat retina. "
5.	Vaccinia 01/25/2002 - "Nonphosphorylatable mutant eIF2alpha, knockout of PKR and PKR inhibitors 2-aminopurine, transdominant-negative PKR, or vaccinia E3L correspondingly enhances translation of IFN-gamma mRNA. " 10/24/2003 - "Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications."

Related Drugs and Biologics

1.	Proto-Oncogene Proteins c-fos (FRAs)
2.	Catecholamines
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Phosphotransferases (Kinase)
6.	Protein Kinase Inhibitors
7.	eIF-2 Kinase (eIF 2 Kinase)
8.	Double-Stranded RNA (RNA, Double Stranded)
9.	RNA (Ribonucleic Acid)
10.	Protein Kinases (Protein Kinase)

Related Therapies and Procedures

1.	Axotomy
2.	Punctures
3.	Ligation