1-Naphthylisothiocyanate (1 Naphthylisothiocyanate)

A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.

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Networked: 168 relevant articles (13 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Luyendyk, James P: 8 articles (11/2021 - 04/2009)
2.	Ma, Xiao: 6 articles (12/2018 - 01/2015)
3.	Ding, Yan: 6 articles (12/2016 - 03/2008)
4.	Zhu, Yun: 5 articles (05/2017 - 03/2012)
5.	Zhao, Lei: 5 articles (12/2016 - 03/2008)
6.	Oliveira, Paulo J: 5 articles (03/2003 - 05/2002)
7.	Palmeira, Carlos M: 5 articles (03/2003 - 05/2002)
8.	Rolo, Anabela P: 5 articles (03/2003 - 05/2002)
9.	Santos, Maria S: 5 articles (03/2003 - 05/2002)
10.	Seiça, Raquel: 5 articles (03/2003 - 05/2002)

Related Diseases

1.	Cholestasis 07/01/2002 - "Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate." 01/01/2023 - "Materials and methods: In this study, an alpha-naphthylisothiocyanate (ANIT)-induced cholestasis mouse model and FXR-/- mice were established to investigate the effect of FXR on cholestasis. " 12/21/2022 - "In this study, an alpha-naphthylisothiocyanate (ANIT)-induced cholestasis rat model was established to examine the anticholestatic effects of DHXSD using histopathological and molecular analyses. " 01/01/2021 - "In this study, wild-type (WT) and Pparα-null (KO) mice were dosed alpha-naphthylisothiocyanate (ANIT) diet to induce chronic cholestasis. " 07/01/2002 - "This study was aimed to evaluate liver mitochondrial bioenergetics of alpha-naphthylisothiocyanate-treated Wistar rats, an experimental model of cholestasis. "
2.	Wounds and Injuries (Trauma) 01/01/2016 - "In this study, we investigated the protective effect of GEN against liver injuries induced by alpha-naphthylisothiocyanate (ANIT). " 02/01/1992 - "In this study, the protective activities of the fractions extracted from the callus of AN were investigated on the alpha-naphthylisothiocyanate (ANIT)-induced liver injuries in rat. " 12/01/1993 - "Protective effects of 41 Taiwan crude drugs on rat hepatic injuries caused by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) were investigated. " 04/01/1992 - "showed protective effects on liver injuries induced by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) in rats. " 01/01/1998 - "Effect of pretreatment of rats with an urinary preparation on liver injuries induced by carbon tetrachloride and alpha-naphthylisothiocyanate."
3.	Intrahepatic Cholestasis 01/01/2021 - "In this study, we reported that AP attenuated liver injury in a mouse model of intrahepatic cholestasis induced by alpha-naphthylisothiocyanate (ANIT). " 02/01/1999 - "alpha-Naphthylisothiocyanate (ANIT) induces intrahepatic cholestasis in rats, involving damage to biliary epithelial cells; our study aims to investigate whether disruption of biliary function in hepatocytes can contribute to early stages of ANIT-induced intrahepatic cholestasis. " 01/01/2020 - "We generated a murine model of intrahepatic cholestasis in LCAT-deficient (KO), wild type (WT), and LCAT-transgenic (Tg) mice by gavaging mice with alpha-naphthylisothiocyanate (ANIT), a drug well known to induce intrahepatic cholestasis. " 01/01/2020 - "Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats." 01/01/2019 - "Effect of compound Yindan decoction on alpha-naphthylisothiocyanate-Induced acute intrahepatic cholestasis in rats."
4.	Hepatitis 04/02/2015 - "The present study was designed to investigate the protective effects of Chi-Dan-Tui-Huang decoction (CDTHD) against Alpha-naphthylisothiocyanate (ANIT) induced acute cholestatic hepatitis in rats and explore the dose-effect relationship of CDTHD as a reference for clinical application. " 03/03/2021 - "A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model." 04/02/2015 - "Large dose means significant effect--dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats." 03/17/2009 - "On the 5th day gastric perfusion of alpha-naphthylisothiocyanate (ANIT) was performed to establish models of cholestatic hepatitis. " 08/01/2006 - "Alpha-naphthylisothiocyanate (ANIT) is a hepatotoxicant that causes acute cholestatic hepatitis with infiltration of neutrophils around bile ducts and necrotic hepatocytes. "
5.	Body Weight (Weight, Body) 03/29/1999 - "An association between lipid peroxidation and alpha-naphthylisothiocyanate (ANIT)-induced liver injury was examined in rats injected once with the toxicant (75 mg/kg body weight). " 01/01/1987 - "Three basic mechanisms were differentiated: Permeabilization of the bilio-sinusoidal barrier associated with electron microscopic alterations of the tight junctional complexes was found in livers of rats treated with alpha-naphthylisothiocyanate (ANIT, 250 mg/kg body weight). " 01/01/1980 - "Intrahepatic cholestatic rat livers were studied with the scanning electron microscopy at 3, 24, 48 and 96 hours after a single dose administration of alpha-naphthylisothiocyanate (ANIT, 100 mg/kg body weight). " 01/01/2020 - "The present study was designed to evaluate the protective effects of echinochrome (Ech) on intrahepatic cholestasis in rats induced by a single (i.p.) injection of alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight). " 12/01/1980 - "In order to clarify the mechanism of alpha-naphthylisothiocyanate (ANIT) induced cholestasis in rats, a few hepatic changes seen after administration of ANIT 80 mg/kg body weight were examined in relation to time. "

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Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
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3.	Ligation
4.	Oral Administration
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