1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

Also Known As:

Networked: 183 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jung, Hee Jin: 4 articles (05/2021 - 03/2018)
2.	Chun, Pusoon: 3 articles (05/2021 - 03/2018)
3.	Moon, Hyung Ryong: 3 articles (05/2021 - 03/2018)
4.	Chung, Hae Young: 3 articles (12/2018 - 03/2018)
5.	Noh, Sang Gyun: 3 articles (12/2018 - 03/2018)
6.	Kang, Dongwan: 2 articles (05/2021 - 10/2018)
7.	Park, Yujin: 2 articles (05/2021 - 10/2018)
8.	Ullah, Sultan: 2 articles (05/2021 - 03/2018)
9.	Wong, Chin Piow: 2 articles (09/2019 - 10/2016)
10.	Be Tu, Pham Thi: 2 articles (01/2017 - 06/2015)

Related Diseases

1.	Ataxia (Dyssynergia) 10/20/1986 - "Significantly greater ethanol-induced motor incoordination was seen in animals fed IBMX, 30 and 60 mg/kg/24 h, compared to controls. " 01/01/1987 - "A significant potentiation of ethanol-induced ataxia was produced in all strains of mice at 20, 45 and 75 min after ethanol in mice pretreated with 62.5 mg/kg caffeine and 12.5 mg/kg IBMX. " 10/20/1986 - "Ethanol-induced increased motor incoordination in caffeine and IBMX-fed animals was also associated with significantly greater 3H-R-PIA binding in whole brains compared to tap water controls indicating an increase in brain adenosine binding sites. " 01/01/1987 - "The effect of the methylxanthines caffeine, theophylline and isobutylmethylxanthine (IBMX) on ethanol-induced ataxia and loss of righting reflex was investigated in three strains of mice. " 10/20/1986 - "The increased motor incoordination associated with increased adenosine binding sites in the brains of caffeine and IBMX-fed animals suggests an involvement of central adenosine mechanisms in the motor incoordinating effect of ethanol and further supports our earlier suggestion for the role of adenosine in some of the central effects of ethanol."
2.	Herpes Zoster 01/01/1993 - "Forskolin was more effective in zona-free oocytes than in cumulus-enclosed oocytes in inhibiting nuclear maturation (24% mature oocytes versus 73% in control medium) even after 24 h of culture; its effect was potentiated by IBMX; forskolin also stimulated cAMP synthesis.(ABSTRACT TRUNCATED AT 250 WORDS)"
3.	Melanoma (Melanoma, Malignant) 03/20/2020 - "Anti-Melanogenic Effect of Ethanolic Extract of Sorghum bicolor on IBMX-Induced Melanogenesis in B16/F10 Melanoma Cells." 04/01/2012 - "Present study was also investigated the inhibitory effects of each or complex of BCAAs at each 10 mM concentration on the 100 μM IBMX-mediated stimulation of melanogenesis in melanoma cells for 72 h and found that IBMX treatment was stimulated to enhance melanin synthesis and that the complex of BCAAs was the most effectively inhibited in the melanin amounts of cellular and extracellular and the whitening the cell pellet. " 03/20/2020 - "In addition, ESB treatment effectively inhibited melanin production in IBMX-induced B16/F10 melanoma cells. " 02/05/2016 - "Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK." 11/15/2009 - "In animal experiments, the metastatic potential of the alpha-MSH- or IBMX-treated B16F10 melanoma cells was decreased compared to untreated control cells. "
4.	Glioma (Gliomas) 01/01/2019 - "Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway." 08/01/1992 - "If used in concentrations that induce growth arrest, both 8CPTcAMP and IBMX, but not 8ClcAMP, induced morphological differentiation of the glioma cells. " 07/01/1979 - "The effect of dibutyryl cAMP could be mimicked by prostaglandin E1 and 3-isobutyl-1-methylxanthine, both of which are known to raise cAMP levels in neuroblastoma-glioma hybrid cells. " 12/01/2011 - "Pharmacologically manipulating endogenous cGMP generation in glioma cells through either stimulating pGC by ANP/BNP, or blocking PDE by 3-isobutyl-1-methylxanthine/zaprinast caused significant inhibition of proliferation and colony formation of glioma cells. " 01/01/2019 - "We aimed to find out the underlying mechanism of forskolin (Fsk) and 3-isobutyl-1-methylxanthine (IBMX) on glioma stem cells (GSCs). "
5.	Hypoxia (Hypoxemia) 01/01/2017 - "IBMX protects human proximal tubular epithelial cells from hypoxic stress through suppressing hypoxia-inducible factor-1α expression." 06/01/2006 - "In the absence of IBMX, chronic hypoxia had no significant effect on rates of cGMP accumulation. " 01/01/2017 - "Taken together, our study showed novel evidence that the PDE inhibitor IBMX can downregulate the transcription of HIF-1α, and thus may attenuate hypoxia induced renal fibrosis." 01/01/2017 - "Moreover, IBMX reduced production of a mesenchymal transformation factor, β-catenin; as well as protected against hypoxia induced cell-death. " 01/01/2010 - "Acute hypoxia enhanced the effects of IBMX and PDE4 inhibitors on cAMP accumulation in CAs and CBs. "

Related Drugs and Biologics

1.	Colforsin
2.	Caffeine (No Doz)
3.	Adenosine (Adenocard)
4.	Ethanol (Ethyl Alcohol)
5.	1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)
6.	Melanins (Melanin)
7.	alpha-MSH
8.	Theophylline (Theon)
9.	Melanocyte-Stimulating Hormones (MSH)
10.	Monophenol Monooxygenase (Tyrosinase)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Topical Administration