1-Carboxyglutamic Acid (1 Carboxyglutamic Acid)

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

Also Known As:

Networked: 68 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gruber, Helen E: 1 article (01/2014)
2.	Hanley, Edward N: 1 article (01/2014)
3.	Sun, Yubo: 1 article (01/2014)
4.	Norton, Harry James: 1 article (01/2014)
5.	Zinchenko, Natalia: 1 article (01/2014)
6.	Franklin, Atiya M: 1 article (01/2014)
7.	Mauerhan, David R: 1 article (01/2014)
8.	Kristensen, Mette: 1 article (02/2007)
9.	Hels, Ole: 1 article (02/2007)
10.	Bügel, Susanne: 1 article (02/2007)

Related Diseases

1.	Bone Resorption 01/01/1991 - "Serum-free gamma carboxyglutamic acid (free Gla) is a poor biochemical marker of bone resorption in early postmenopausal women." 12/01/2004 - "3. Among the 67 women who completed the study (24 on ISO, 24 on V, 19 on P), only ISO tablets were proven to decrease significantly urinary deoxypyridinoline (Dpd) excretion (P < 0.05 vs before), a specific biomarker of bone resorption, but there was no significant difference in serum bone gamma-carboxyglutamic acid-containing protein (BGP), a specific serum biomarker of bone formation. " 06/01/1985 - "The variables investigated were distal forearm bone mineral content (BMC), biochemical markers of bone formation: serum alkaline phosphatase and serum bone gamma-carboxyglutamic acid containing protein (BGP) and biochemical markers of bone resorption: fasting urinary calcium and fasting urinary hydroxyproline. " 02/01/2007 - "Serum bone-specific alkaline phosphatase as well as the urinary markers of bone resorption (N-telopeptide cross-links of collagen, pyridinoline and deoxypyridinoline) and urinary gamma-carboxyglutamate were unaffected by phylloquinone supplementation. "
2.	Urinary Calculi (Urinary Calculus) 12/01/1985 - "[Study on the causative factor producing urinary calcium stones--urinary excretion of gamma-carboxyglutamic acid under various conditions]."
3.	Osteoporosis 12/01/1983 - "Urinary gamma-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget's disease."
4.	Neoplasms (Cancer) 02/01/2001 - "Growing evidence suggests that most normal and tumor cells possess an active K1-dependent gamma-carboxylation mechanism necessary for the production of gamma-carboxyglutamic acid (Gla)-containing proteins. " 03/01/1993 - "Immunoreactivity for osteocalcin (human bone gamma-carboxyglutamic acid-containing protein) was demonstrated in most of these tumor cells. " 11/16/1982 - "Vitamin K dependent formation of gamma-carboxyglutamate residues in tumor microsomes." 11/01/1980 - "PTH responsiveness correlated with several properties, presumably associated with the osteoblastic phenotype: elevated alkaline phosphatase activity, synthesis of the gamma-carboxyglutamic acid-containing bone protein, and production of mineralized tumors in host rats. " 02/01/1984 - "It is suggested that this case of 'neoplasm-induced post-traumatic myositis ossificans' may be caused by the interaction of local haemorrhage and thrombosis, mucin-producing tumour implants, and the presence of large quantities of gamma-carboxyglutamic acid, an amino acid associated with the calcification of bone matrix formation."
5.	Vitamin K Deficiency 09/01/1989 - "Effect of vitamin K deficiency on urinary gamma-carboxyglutamic acid excretion in rats." 04/01/1985 - "The assay system developed may be useful for the detection of vitamin K deficiency, since a severe deficiency may result in less gamma-carboxyglutamic acid residues in the protein." 03/01/1985 - "Vitamin K deficiency results in the appearance of abnormal prothrombin, deficient in gamma-carboxyglutamic acid, in the blood. " 12/01/1980 - "[Vitamin K and bone metabolism - on the effect of vitamin K deficiency and gamma-carboxyglutamic acid (author's transl)]." 09/01/1990 - "Chemical modification of gamma-carboxyglutamic acid (Gla) residues in human prothrombin to gamma-methyleneglutamic acid (gamma-MGlu) residues elicited a conformation similar, if not identical, to that of des-gamma-carboxy prothrombin or PIVKA-II, i.e., prothrombin molecules induced by vitamin K antagonists or vitamin K deficiency states. "

Related Drugs and Biologics

1.	Osteocalcin
2.	Calcium
3.	deoxypyridinoline
4.	Tablets
5.	Vitamin K
6.	Proteins (Proteins, Gene)
7.	Prothrombin (Factor II)
8.	Protein C
9.	Alkaline Phosphatase
10.	acarboxyprothrombin (PIVKA)

Related Therapies and Procedures

1.	Pancreas Transplantation
2.	Renal Dialysis (Hemodialysis)