Zolazepam

A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.

Also Known As:

CI-716; Flupyrazopon; Zolasepam; Zolazepam Hydrochloride; CI 716; CI716; Hydrochloride, Zolazepam; Flupyrazapon; Pyrazolo(3,4-e)(1,4)diazepin-7(1H)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Zolazepam: 15
      - zolazepam drug combination tiletamine: 51

Experts

1.	Martelli, Paolo: 1 article (05/2021)
2.	Oh, Serena: 1 article (05/2021)
3.	Bootcha, Ratikorn: 1 article (12/2018)
4.	Pattanapon, Nakrob: 1 article (12/2018)
5.	Petchdee, Soontaree: 1 article (12/2018)
6.	Fayyisaa, Tafarraa: 1 article (10/2018)
7.	Feyyiss, Rattaa: 1 article (10/2018)
8.	Lusiani, Marta: 1 article (10/2018)
9.	Manenti, Fabio: 1 article (10/2018)
10.	Merler, Stefano: 1 article (10/2018)

Related Diseases

1.	Hypoxia (Hypoxemia) 03/01/2010 - "This study assessed whether arterial oxygenation could be increased by treatment with intranasal oxygen supplementation in brown bears (Ursus arctos) with hypoxemia during anesthesia with medetomidine-zolazepam-tiletamine. " 01/01/2014 - "For wild bears darted from a helicopter, a dose of 2.06 mg tiletamine, 2.06 mg zolazepam, and 10.1 µg dexmedetomidine/kg produced ataxia in 2.5 ± 0.3 min and anesthesia in 5.5 ± 1.0 min. Contrary to published accounts of bear anesthesia with medetomidine, tiletamine, and zolazepam, this combination did not cause hypoxemia or hypoventilation, although mild bradycardia (<50 beats per min) occurred in most bears during the active season. "
2.	Body Weight (Weight, Body) 03/01/2012 - "Pigs were given tiletamine/zolazepam intramuscularly at a dose of 4.4 mg kg(-1) (2.2 mg kg(-1) tiletamine and 2.2 mg kg(-1) zolazepam) of body weight. " 01/01/2000 - "Seven wood bison received 1.5 mg/kg body weight (BW) of xylazine HCl + 1.5 mg/kg BW of zolazepam HCl and 1.5 mg/kg BW of tiletamine HCl on one occasion. " 12/01/1990 - "Forty seven free-ranging, adult, male koalas were captured and administered an intramuscular injection of the dissociative anaesthetic, Telazol (tiletamine HCl plus zolazepam HCl), at dose rates of 5.0 to 7.7 mg/kg body weight. " 12/01/2018 - "The dogs were pre-medicated with four protocols; (1) alfaxalone [at 3 mg/kg body weight (bwt)], (2) zolazepam + tiletamine (Zoletil) (at 5 mg/kg bwt), (3) diazepam (at 0.3 mg/kg bwt) + ketamine (at 5 mg/kg bwt), and (4) diazepam (at 0.3 mg/kg bwt) + propofol (at 5 mg/kg bwt). " 12/01/2000 - "Two minutes after exercise, horses received a combination of xylazine hydrochloride (2.2 mg/kg of body weight) and acepromazine maleate (0.04 mg/kg) IV. Five minutes after exercise, horses received 1 of the following 4 IV anesthetic regimens: ketamine hydrochloride (2.2 mg/kg); ketamine (2.2 mg/kg) and diazepam (0.1 mg/kg); tiletamine hydrochloride-zolazepam hydrochloride (1 mg/kg); and guaifenesin (50 mg/kg) and thiopental sodium (5 mg/kg). "
3.	Bradycardia 07/01/1992 - "Bradycardia occurred after administration of detomidine, but heart rates returned to baseline values 5 minutes after administration of tiletamine and zolazepam. " 03/01/2006 - "A tiletamine hydrochloride-zolazepam hydrochloride combination was used successfully to immobilize 27 free-ranging maned wolves (Chrysocyon brachyurus) at a mean dose of 2.77+/-0.56 (mean+/-SD) mg/kg. The induction time ranged from 3-15 min. Animals remained immobilized for periods of 48.56 +/-12.65 min. Compulsive licking, excessive salivation, muscle twitching, muscle tremors, tachypnea, and bradycardia were observed associated with the induction of the anesthesia in 13 of 27 maned wolves. " 12/01/1999 - "Hypertension, bradycardia, and decreased Pao2 were observed with both medetomidine-ketamine and medetomidine-zolazepam-tiletamine. " 01/01/2014 - "For wild bears darted from a helicopter, a dose of 2.06 mg tiletamine, 2.06 mg zolazepam, and 10.1 µg dexmedetomidine/kg produced ataxia in 2.5 ± 0.3 min and anesthesia in 5.5 ± 1.0 min. Contrary to published accounts of bear anesthesia with medetomidine, tiletamine, and zolazepam, this combination did not cause hypoxemia or hypoventilation, although mild bradycardia (<50 beats per min) occurred in most bears during the active season. "
4.	Tachypnea 03/01/2006 - "A tiletamine hydrochloride-zolazepam hydrochloride combination was used successfully to immobilize 27 free-ranging maned wolves (Chrysocyon brachyurus) at a mean dose of 2.77+/-0.56 (mean+/-SD) mg/kg. The induction time ranged from 3-15 min. Animals remained immobilized for periods of 48.56 +/-12.65 min. Compulsive licking, excessive salivation, muscle twitching, muscle tremors, tachypnea, and bradycardia were observed associated with the induction of the anesthesia in 13 of 27 maned wolves. "
5.	Tremor (Tremors) 03/01/2006 - "A tiletamine hydrochloride-zolazepam hydrochloride combination was used successfully to immobilize 27 free-ranging maned wolves (Chrysocyon brachyurus) at a mean dose of 2.77+/-0.56 (mean+/-SD) mg/kg. The induction time ranged from 3-15 min. Animals remained immobilized for periods of 48.56 +/-12.65 min. Compulsive licking, excessive salivation, muscle twitching, muscle tremors, tachypnea, and bradycardia were observed associated with the induction of the anesthesia in 13 of 27 maned wolves. "

Related Drugs and Biologics

1.	Tiletamine
2.	Medetomidine
3.	Oxygen (Dioxygen)
4.	Ketamine
5.	Xylazine (Xylazin)
6.	Anesthetics (Anesthetic Agents)
7.	zolazepam drug combination tiletamine
8.	Diazepam (Valium)
9.	Dexmedetomidine
10.	Propofol (Diprivan)

Related Therapies and Procedures

1.	Anesthesia
2.	Deep Sedation
3.	Intramuscular Injections