Zinc

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Networked: 10736 relevant articles (549 outcomes, 1832 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Black, Robert E: 60 articles (12/2015 - 12/2002)
2.	Mocchegiani, Eugenio: 35 articles (09/2014 - 04/2003)
3.	Supuran, Claudiu T: 34 articles (01/2015 - 05/2003)
4.	Malavolta, Marco: 29 articles (09/2014 - 01/2005)
5.	Bush, Ashley I: 28 articles (09/2015 - 07/2003)
6.	Koh, Jae-Young: 27 articles (12/2015 - 05/2002)
7.	Bhutta, Zulfiqar A: 25 articles (02/2015 - 09/2006)
8.	Franklin, Renty B: 25 articles (01/2015 - 12/2003)
9.	Prasad, Ananda S: 24 articles (10/2014 - 01/2002)
10.	Chan, Pak H: 24 articles (02/2013 - 01/2002)

Related Diseases

1.	Diarrhea 05/01/2010 - "Zinc supplementation has proven beneficial in the treatment of acute child diarrhea and appears to enhance linear growth. " 05/01/2013 - "Zinc was beneficial for reducing the duration of diarrhea in hours (mean difference [MD] = -20.12, 95% confidence interval [CI] = -29.15 to -11.09, I² = 91%). " 05/01/2010 - "In addition, Zinc supplement significantly reduced the severity of diarrhea and duration of the episode. " 06/01/2007 - "Several reports from developing countries have demonstrated that supplements of zinc also provide significant reduction in stool output and duration, persistency, and severity of diarrhea. " 10/01/2006 - "Supplemental zinc had no significant effect on the duration or remission of diarrhea in HIV-infected adults."
2.	Infection 01/01/2011 - "An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques." 01/01/2006 - "A properly prepared immune egg product, spray-dried plasma, or a high level of dietary zinc can provide protection against enteric infection in young pigs. " 09/01/1995 - "The addition of zinc may be beneficial in certain clinical situations, such as wound healing, zinc deficiency and infections involving toxin-producing bacteria, e.g. " 11/01/1984 - "Of eleven patients with serum zinc below 10 mumol/l, six had recurrent infections of the skin, a significantly greater proportion than in patients whose serum zinc was 10 mumol/l or above. " 01/01/2015 - "Targeted interventions like initiating corticosteroid or its dose-adjustment during episodes of acute respiratory infection and zinc supplementation are reportedly effective in reducing relapse rates. "
3.	Hepatolenticular Degeneration (Wilson's Disease) 10/01/2011 - "In 4 young pediatric patients with presymptomatic Wilson disease, we found zinc monotherapy beginning at time of diagnosis to be safe and highly effective for follow-up intervals between 1 and 2 years. " 12/01/2015 - "Zinc therapy is considered a good option in Wilson disease (WD), as a first-line treatment in presymptomatic children and a maintenance therapy after the initial chelator therapy. " 05/01/2009 - "Zinc is an effective treatment for Wilson disease. " 08/04/1984 - "Effective treatment of Wilson's disease with oral zinc sulphate: two case reports." 10/01/1982 - "Effective treatment of Wilson's disease with oral zinc."
4.	Common Cold 01/01/2013 - "Intake of zinc was associated with a significant reduction in the duration (days) (mean difference (MD) -1.03, 95% confidence interval (CI) -1.72 to -0.34) (P = 0.003) (I(2) statistic = 89%) but not the severity of common cold symptoms (MD -1.06, 95% CI -2.36 to 0.23) (P = 0.11) (I(2) statistic = 84%). " 01/01/2011 - "Intake of zinc is associated with a significant reduction in the duration (standardized mean difference (SMD) -0.97; 95% confidence interval (CI) -1.56 to -0.38) (P = 0.001), and severity of common cold symptoms (SMD -0.39; 95% CI -0.77 to -0.02) (P = 0.04). " 05/01/2003 - "Zinc nasal gel effective for the common cold." 10/01/2000 - "These results provide evidence that zinc nasal gel is effective in shortening the duration of common cold symptoms off when taken within 24 hours of their onset." 06/01/2009 - "Is intranasal zinc effective and safe for the common cold? "
5.	Neoplasms (Cancer) 04/01/2014 - "A consistent marked decrease in zinc in HCC tumors compared with normal liver is an established clinical relationship, which occurs in virtually all cases of HCC. " 01/01/2015 - "Zinc sulfophthalocyanine (ZnPcSmix) has been shown to be effective in A549 monolayers, multicellular tumor spheroids (MCTSs) (250 µm) and not on MCTSs with a size of 500 µm. " 01/01/2008 - "This metabolic transformation is essential so that the tumor suppressive effects of zinc can be eliminated and the malignant process can proceed. " 01/01/2002 - "Zinc supplementation is associated with decreased oxidative stress and improved immune function, which may be among the possible mechanisms for its cancer preventive activity. " 04/15/2014 - "In this study, we assessed the cancer-selective accumulation of zinc-labeled glycoconjugated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (ZnGlc1-4), both in vitro and in vivo. "

Related Drugs and Biologics

1.	Copper
2.	Selenium
3.	Vitamin A (Retinol)
4.	Ascorbic Acid (Vitamin C)
5.	Iron
6.	Superoxide Dismutase
7.	Micronutrients
8.	Dentifrices (Dentifrice)
9.	Penicillamine (Cuprimine)
10.	Vitamins

Related Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy)
2.	Oral Administration
3.	Radiotherapy
4.	Renal Dialysis (Hemodialysis)
5.	Aftercare (After-Treatment)