Zeranol

A non-steroidal estrogen analog.

Also Known As:

P-1496; P1496; Ralgro; Ralone; Xeranol; Zearanol; P 1496; Dihydroxyundecyl Resorcylic Acid Lactone; Zearalanol; 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-, (3S-(3R*,7S*))-

Networked: 71 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lin, Young C: 14 articles (01/2013 - 01/2002)
2.	Lin, Shu-Hong: 8 articles (05/2011 - 11/2009)
3.	Zhong, Saiyi: 7 articles (07/2016 - 11/2010)
4.	Ye, Weiping: 7 articles (05/2011 - 01/2007)
5.	Liu, Jie-Yu: 6 articles (05/2011 - 11/2010)
6.	Feng, Eric: 6 articles (02/2011 - 09/2010)
7.	Li, Hong: 5 articles (01/2011 - 09/2010)
8.	Xu, Pingping: 5 articles (01/2011 - 11/2009)
9.	Liu, Suling: 5 articles (01/2007 - 01/2002)
10.	Kulp, Samuel K: 3 articles (01/2013 - 01/2002)

Related Diseases

1.	Weight Gain 03/01/1984 - "Zeranol implants did not significantly affect marketing-transit weight changes, but increased (P less than .05) daily weight gains at all time periods in both trials. " 04/01/1983 - "In a trial to determine the effect of zeranol implants on weight gains from birth to 180 days of age, 269 male Holstein calves were assigned randomly to one of three groups: a) 56 intact calves, b) 106 castrated calves implanted at birth and again at 90 days with 36 mg zeranol, and c) 107 castrated controls. " 04/01/1994 - "At initiation of a 140-day postweaning weight gain test, Angus bulls were assigned in equal numbers (n = 5) to 1 of 3 treatment groups to determine effects of implantation with zeranol, an estrogenic growth promotant, on selected reproductive characteristics. " 04/01/1994 - "Effects of zeranol implanted during a postweaning weight gain test on testicular, semen, and endocrine characteristics of bulls." 12/01/1989 - "Zeranol increased daily live weight gain and feed conversion in animals in continuous growth as well as in those observed in compensatory growth an tended to eliminate a tendency for higher content of fat in carcasses of nonimplanted animals making compensatory growth."
2.	Brain Ischemia (Cerebral Ischemia) 01/15/2019 - "Zeranol has neuroprotective potential against cerebral ischemia reperfusion in ovariectomized rats." 01/15/2019 - "The protective effect of zeranol in cerebral ischemia reperfusion via p-CREB overexpression." 01/15/2019 - "The objective of this study is to investigate the neuroprotective effect of zeranol against cerebral ischemia reperfusion in ovariectomized rats. " 06/15/2019 - "ERK activation by zeranol has neuroprotective effect in cerebral ischemia reperfusion."
3.	Breast Neoplasms (Breast Cancer) 12/01/2010 - "This study hypothesized that obese individuals may be at greater risk of developing zeranol-induced breast cancer. " 05/01/2011 - "Consumption of beef derived from Zeranol-implanted cattle may be a risk factor for breast cancer. " 02/01/2011 - "Bio-active zeranol metabolites contained in meat produced from cattle after zeranol implantation may be a risk factor for breast cancer." 02/01/2011 - "Consumption of beef derived from zeranol-implanted cattle may be a risk factor for breast cancer. " 02/01/2011 - "Serum derived from zeranol-implanted ACI rats promotes the growth of human breast cancer cells in vitro."
4.	Postmenopausal Osteoporosis 11/01/2016 - "α-Zearalanol treated rats reduced the resorption of bone, and showed a preventive and therapeutic effect of α-Zearalanol on postmenopausal osteoporosis." 09/01/1997 - "Thus, for the first time, the bioactivity of coumestrol and zearalanol in preventing bone loss has been demonstrated in a well-recognized model of postmenopausal bone loss." 11/01/2016 - "The aim of this study was to observe the influence of phytoestrogen α-Zearalanol on ovariectomy-induced postmenopausal osteoporosis in rats. " 09/01/1997 - "To examine a potential role for phytoestrogens in postmenopausal bone loss, the oophorectomized (OOX) rat model has been used in three studies to investigate the effects of the phytoestrogens coumestrol, zearalanol and a mixture of isoflavones on estrogen-dependent bone loss. "
5.	Alzheimer Disease (Alzheimer's Disease) 09/01/2013 - "The aim of this study was to evaluate the effect of a novel phytoestrogen, α-Zearalanol, on Alzheimer's disease-related memory impairment and neuronal oxidation in ovariectomized mice. " 10/01/2017 - "Our previous studies demonstrated both phytoestrogen α-zearalanol (α-ZAL) and estrogen is effective decrease Alzheimer's disease (AD)-like apoptotic neuron death, but α-ZAL showed significantly less side-effect on breast and endometrial tissue compared to estrogen, it suggested that α-ZAL can be used as a potential substitute for estrogen. "

Related Drugs and Biologics

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2.	DNA (Deoxyribonucleic Acid)
3.	Cathepsin D
4.	Phytoestrogens (Phytoestrogen)
5.	Estrogens (Estrogen)
6.	Neuroprotective Agents
7.	Estrogen Receptors
8.	Methoxychlor (Metox)
9.	Isoflavones
10.	Homocysteine

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Subcutaneous Injections
3.	Injections
4.	Castration