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Yohimbine (Yocon)

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic in the treatment of ERECTILE DYSFUNCTION.

Also Known As:

Yocon; Yohimbine Hydrochloride; Yohimex; Aphrodine Hydrochloride; Aphrodyne; Aventis Brand of Yohimbine Hydrochloride; Corynanthine; Corynanthine Tartrate; Glenwood Brand of Yohimbine Hydrochloride; Kramer Brand of Yohimbine Hydrochloride; Palisades Brand of Yohimbine Hydrochloride; Pluriviron; Rauhimbine; Solvay Brand of Yohimbine Hydrochloride; Star Brand of Yohimbine Hydrochloride; StegroPharm Brand of Yohimbine Hydrochloride; Yohimbin Spiegel; Yohimbine Houdé; Hydrochloride, Aphrodine; Hydrochloride, Yohimbine; Tartrate, Corynanthine; Rauwolscine; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-

Networked: 785 relevant articles (48 outcomes, 76 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Alkaloids: 1065
  - Indole Alkaloids: 36
    - Secologanin Tryptamine Alkaloids: 55
      - Yohimbine: 785
        Reserpine: 2013
        raubasine drug combination almitrine: 20
        afrodex: 6
        Iskedyl: 5
        Isosarpan: 3
        lipokinetix: 3
        11-hydroxy-yohimbine: 1
        yohimbine drug combination piribedil papaverine ifenprodil tartrate dipyridamole atropine: 1
        yohimbine-arginine combination: 1
        1-methylyohimbine
        10-hydroxyyohimbine
        11-hydroxyyohimbine
        14-(4-nitrobenzoyloxy)yohimbine
        14-benzoyloxyyohimbine
        17-hydroxy-20-yohimban-16-(N-(4-azido-3-iodo)phenyl)carboxamide
        5-carboxytetrahydroalstonine
        9-methoxy-3-epi-alpha-yohimbine
        apoyohimbine
        iodinated rauwolscine-OHPC
        NMI 187
        Pasuma (injection)
        Pasuma (tablet)
        rauwolscine 4-aminophenylcarboxamide
        rauwolscine-OHPC
        trimethoxybenzoylyohimbine
        yohimbine-agarose matrix
        yohimbinic acid
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - Indole Alkaloids: 36
      - Secologanin Tryptamine Alkaloids: 55
        Yohimbine: 785
        Reserpine: 2013
        raubasine drug combination almitrine: 20
        afrodex: 6
        Iskedyl: 5
        Isosarpan: 3
        lipokinetix: 3
        11-hydroxy-yohimbine: 1
        yohimbine drug combination piribedil papaverine ifenprodil tartrate dipyridamole atropine: 1
        yohimbine-arginine combination: 1
        1-methylyohimbine
        10-hydroxyyohimbine
        11-hydroxyyohimbine
        14-(4-nitrobenzoyloxy)yohimbine
        14-benzoyloxyyohimbine
        17-hydroxy-20-yohimban-16-(N-(4-azido-3-iodo)phenyl)carboxamide
        5-carboxytetrahydroalstonine
        9-methoxy-3-epi-alpha-yohimbine
        apoyohimbine
        iodinated rauwolscine-OHPC
        NMI 187
        Pasuma (injection)
        Pasuma (tablet)
        rauwolscine 4-aminophenylcarboxamide
        rauwolscine-OHPC
        trimethoxybenzoylyohimbine
        yohimbine-agarose matrix
        yohimbinic acid

Experts

1.	Dehpour, Ahmad Reza: 4 articles (08/2013 - 08/2002)
2.	Stepanović-Petrović, Radica M: 4 articles (06/2013 - 11/2006)
3.	Tomić, Maja A: 4 articles (06/2013 - 11/2006)
4.	Andurkar, Shridhar V: 3 articles (10/2013 - 01/2011)
5.	Gulati, Anil: 3 articles (10/2013 - 01/2011)
6.	Suleyman, Halis: 3 articles (03/2013 - 05/2007)
7.	Robertson, David: 3 articles (11/2010 - 02/2008)
8.	Goldstein, David S: 3 articles (11/2008 - 07/2002)
9.	Diedrich, André: 3 articles (08/2008 - 11/2007)
10.	Min, Byung-Il: 3 articles (10/2005 - 03/2005)

Related Diseases

1.	Erectile Dysfunction 03/01/1997 - "Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? " 02/01/1998 - "The meta-analysis demonstrated that yohimbine is superior to placebo in the treatment of erectile dysfunction (odds ratio 3.85, 95% confidence interval 6.67 to 2.22). " 03/01/1997 - "Yohimbine is no better than placebo as a first-line treatment for mixed-type impotence." 12/01/1996 - "Based on the data to date, yohimbine does not appear to be effective for organic erectile dysfunction and, thus, it should not be recommended as treatment for the standard patient. " 08/22/1987 - "Yohimbine is a safe treatment for psychogenic impotence that seems to be as effective as sex and marital therapy for restoring satisfactory sexual functioning."
2.	Panic Disorder (Panic Attack) 07/01/2012 - "Avoidant coping in panic disorder: a yohimbine biological challenge study." 10/01/1992 - "Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: a study of power spectral analysis of heart rate." 01/01/1992 - "In contrast to other yohimbine challenge studies no panic attacks were observed. " 04/01/1991 - "In light of the appearance of cyclic enervative episodes, this study suggests limitations to primate models of panic disorder utilizing oral yohimbine." 02/01/1989 - "These findings contrast with previous studies of the effects of yohimbine in panic disorder patients and, thereby, support a neurobiological distinction between these two disorders."
3.	Orthostatic Hypotension (Postural Hypotension) 01/01/1980 - "Yohimbine appears to be the most effective treatment for orthostatic hypotension, either essential or induced by thymoanaleptic or neuroleptic therapy." 02/01/1987 - "Yohimbine may be useful in the treatment of orthostatic hypotension associated with autonomic failure. " 01/01/1997 - "Yohimbine has been proposed for the treatment of neurogenic orthostatic hypotension; however, no controlled trial has been performed in experimental models of orthostatic hypotension or in patients with autonomic failure. " 01/01/1993 - "Lack of yohimbine effect on ambulatory blood pressure recording: a double-blind cross-over trial in parkinsonians with orthostatic hypotension." 01/01/1997 - "These results show that, in the model of orthostatic hypotension obtained by SAD, yohimbine, at an alpha 2-adrenoceptor selective dose (0.05 mg/kg), delays the fall in blood pressure elicited by head-up tilting. "
4.	Bradycardia 08/01/2011 - "Sixty-three percent of the horses (8, 6, and 4 of the 9 horses in the 0.1, 0.2, and 0.4 mg/kg dose groups, respectively) exhibited second-degree atrial-ventricular conduction blocks and bradycardia prior to drug administration that transiently improved or disappeared upon administration of yohimbine. " 10/01/2011 - "Blockade of α2-adrenoreceptors with yohimbine did not change heart rate in 6- and 20-week-old rats and induced bradycardia in 1- and 3-week old rats." 11/01/2007 - "Yohimbine attenuates baroreflex-mediated bradycardia in humans." 09/01/1992 - "pretreatment with the alpha 2-antagonist yohimbine (10 micrograms) counteracted depressor responses and bradycardia produced by i.t. " 09/01/1989 - "Yohimbine also caused a dose-dependent reversal of JSL-induced bradycardia. "
5.	Post-Traumatic Stress Disorders (PTSD) 11/01/2013 - "The proposed investigation entails a randomized, placebo-controlled trial investigating the effect of a single administration of yohimbine HCL (paired with the first session of imaginal exposure) on outcome of PE in 40 veterans with PTSD. " 11/01/2013 - "Enhancing exposure therapy for PTSD with yohimbine HCL: protocol for a double-blind, randomized controlled study implementing subjective and objective measures of treatment outcome." 08/01/1999 - "In a recent neuroendocrine challenge study, IV yohimbine caused exaggerated subjective, behavioral, cardiovascular and catecholamine responses among combat veterans with PTSD compared to healthy controls. " 02/01/1995 - "This study demonstrates an excitatory effect of yohimbine on the amplitude, magnitude and probability of the ASR in PTSD patients that is not seen in combat controls.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/01/2008 - "Some of the symptoms of PTSD include persistent anxiety, exaggerated startle, cognitive impairments and increased sensitivity to yohimbine, an alpha(2)-adrenergic receptor antagonist. "

Related Drugs and Biologics

1.	Prazosin (Minipress)
2.	Yohimbine (Yocon)
3.	Norepinephrine (Noradrenaline)
4.	Phentolamine (Z-Max)
5.	Xylazine (Xylazin)
6.	Adrenergic Antagonists (Antiadrenergic Agents)
7.	Methoxyhydroxyphenylglycol
8.	Phenylephrine (Neo-Synephrine)
9.	Indomethacin (Indometacin)
10.	Trazodone (Trittico)

Related Therapies and Procedures

1.	Anesthesia
2.	Immunomodulation
3.	Induced Hypothermia
4.	Drug Therapy (Chemotherapy)
5.	Artificial Respiration (Mechanical Ventilation)