Yersinia Infections

01/01/2019 - "CONCLUSIONS AND CLINICAL RELEVANCE This vaccine had, at most, limited effects on seroconversion and, under the conditions of this study, had no demonstrable impact on liveweight, mean daily liveweight gain or faecal shedding of Yersinia spp. Further studies are needed to determine the efficacy of this vaccine during outbreaks of yersiniosis or following experimental challenge with pathogenic Yersinia spp.."
01/02/2013 - "Prevention of yersiniosis still remains a challenge, and an efficacious and safe vaccine that confers protection against this enteric pathogen needs to be developed. "
05/18/2017 - "A study on the efficacy of the recombinant Yersinia adhesin A vaccine against yersiniosis in the early phase."
09/01/2023 - "Diseases are the most significant challenge in the development and stability of aquaculture. In this study, the immunogenic efficiency of polyvalent streptococcosis/lactococcosis and yersiniosis vaccines was evaluated by injection and immersion methods in rainbow trout.. "
05/18/2017 - "Therefore, this study aimed to develop a vaccine for yersiniosis control. "

01/01/2015 - "Recombinant Bivalent Fusion Protein rVE Induces CD4+ and CD8+ T-Cell Mediated Memory Immune Response for Protection Against Yersinia enterocolitica Infection."
03/05/2014 - "A recombinant bivalent fusion protein rVE confers active and passive protection against Yersinia enterocolitica infection in mice."
11/16/2021 - "To determine how the sequence divergence of YopP/J has impacted Yersinia virulence, we examined protein polymorphisms in this type III secreted effector protein across 17 Yersinia species and tested the consequences of polymorphism in a murine model of subacute systemic yersiniosis. "
07/01/2019 - "The current understanding suggests that mostly protein based interactions between bacteria and host determine host cell specific effector translocation during Yersinia infection. "
01/01/2019 - "A shift from green to blue emission spectra of individual cells is indicative of translocation of a given Yop-TEM fusion protein into the host cell during Yersinia infection due to a disruption in FRET between the two fluors of the compound. "

01/01/2009 - "However, statistical analysis of the results showed that the frequency of detecting antibodies among the patients with yersiniosis was significantly higher in relation to blood donors (P < 0.05). "
01/01/2007 - "The obtained results showed that the detection of antibodies to ECA may be useful in serodiagnosis of Yersinia infections."
01/01/2007 - "Statistical analysis showed that the frequency of detecting antibodies for ECA among the patients with yersiniosis was significantly higher (p < 0.05) in relation to the blood donors. "
10/01/2006 - "In conclusion, Yersinia infection does not confer an increased risk of thyroid antibodies. "
10/01/2006 - "Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study."

11/01/2013 - "However, the role and interplay of RIP2 with TLR signalling on cytokine production in macrophages against Yersinia enterocolitica infection remains poorly understood. "
11/01/2013 - "RIP2/RICK-dependent cytokine production upon Yersinia enterocolitica infection in macrophages with TLR4 deficiency."
11/01/2010 - "Response of innate and adaptive immunity cytokine system in cultures in vitro and during experiment was characterized; scarce data on production of cytokines in patients with yersiniosis are presented."
01/01/2006 - "[Clinical significance of intracellular cytokines in patients with yersiniosis]."
03/01/2000 - "Although cytokine therapy with rIL-12 or rIL-18 ameliorated the course of Yersinia infection in ICSBP(-/-) mice, both cytokines failed to completely restore impaired immunity. "

11/01/2008 - "The main changes were detected at day 21 suggesting a chronic effect of Yersinia infection and that IL-12 could play a role in the protection against chronic sequelae in the lung. "
05/01/1998 - "Administration of exogenous IL-12 confers protection against yersiniae in Yersinia-susceptible BALB/c mice but exacerbates yersiniosis in resistant C57BL/6 mice. "
05/01/1998 - "Ambiguous role of interleukin-12 in Yersinia enterocolitica infection in susceptible and resistant mouse strains."
05/01/2010 - "YopJ/P kills macrophages and dendritic cells, reduces their production of tumor necrosis factor alpha (TNF-alpha) and interleukin-12 (IL-12), and promotes systemic colonization in mouse models of intestinal Yersinia infection. "
10/01/2001 - "Hence, we investigated the course of Yersinia infection in mice deficient for the IFN-gamma-inducing cytokines interleukin-12 (IL-12 p40(-/-)) or interleukin-18 (IL-18(-/-)). "

01/01/2012 - "It was shown, that cycloferon had direct and indirect immunotropic action in salmonellosis and yersiniosis in children. "
01/01/2012 - "The efficacy of cycloferon in complex therapy of salmonellosis and yersiniosis in children (n=220) was investigated under clinical and laboratory conditious. "
01/01/2012 - "[Cycloferon use in complex therapy of children with salmonellosis and yersiniosis infection]."
01/01/2011 - "The efficacy of the immunotropic therapy with cycloferon, an interferon inductor, and recombinant interferon in the patients with the viral and bacterial association of the disease (yersiniosis + hepatitis A) and initial disbalance of the serum cytokines was estimated. "

10/01/1985 - "Protection against Yersinia infection induced by non-virulence-plasmid-encoded antigens."
05/18/2017 - "As a result, the survival rate was 100% in group 1, 60% in group 2, and 0% in group 3. The anti-YadA antibody titer increased in a stepwise fashion in groups 1 and 2. The present study results suggest that rYadA shows promise as a protective antigen against yersiniosis. "
04/01/1992 - "During the study of the remaining 40 patients the antigen was detected only in 6 patients, including 3 patients with enteric yersiniosis."
01/01/2016 - "Surprisingly, antigen-specific T cell protection waned over time, as Lm-OVA-immune mice eventually succumbed to Yersinia infection. "
01/01/2008 - "[Humoral response to selected antigens of Yersinia enterocolitica and Yersinia pseudotuberculosis in the course of yersiniosis in humans. "

01/01/2016 - "The study showed that in-house obtained recombinant proteins can be used as highly specific antigens in ELISA and recom-dot performed in the serodiagnosis of yersiniosis. "
01/01/2016 - "The aim of the present study was to evaluate the usefulness of in-house obtained recombinant proteins Yop of Yersinia enterocolitica as highly specific antigens in ELISA and recom-dot performed in the serodiagnosis of yersiniosis. "
01/01/2016 - "Usefulness of in-house obtained recombinant proteins Yop of Yersinia enterocolitica as highly specific antigens in ELISA and recom-dot performed in the serodiagnosis of yersiniosis."
01/01/2016 - "In the group of patients suspected for yersiniosis in clinical investigation the most positive results were obtained in ELISA with the recombinant protein YopD (IgA respectively 25 (42.4%), IgG 41 (69.5%), IgM 24 (40.7%). "
01/01/2009 - "The results of the study revealed that antibodies to all recombinant proteins in diagnostically significant titers were diagnosed only in about half of the tested patients with yersiniosis confirmed by routine ELISA with Yop proteins as antigen. "

04/01/1984 - "In order to study predisposition to high IgA response in AS and yersinia arthritis we measured the in-vitro Ig production in patients with AS and in persons who have once had yersinia arthritis, and we compared it with the Ig production in persons who have had yersiniosis but recovered without getting arthritis and with that in healthy controls. "
01/01/1986 - "In contrast, yersiniosis (n = 12) and shigellosis (n = 96) patients displayed marked increases in specific serum IgA titres to the respective infectants. "
08/01/1989 - "Polyclonal IgA is increased in rheumatoid arthritis, Sjögren's syndrome, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis following Yersinia infection. "
10/01/2006 - "Within discordant twin pairs, the thyroid antibody-positive twin did not have an increased risk of Yersinia infection compared to the thyroid antibody-negative co-twin [odds ratio: YOP IgA-Ab: 0.94 (0.49-1.83), P = 0.866, and YOP IgG-Ab: 1.35 (0.72-2.53), P = 0.345]; 41% (95% CI 10-67% of the liability of being YOP antibody-positive was due to genetic effects. "
10/01/2006 - "Yersinia infection was not associated with a positive thyroid antibody status: the odds ratio (with 95% CI) for YOP IgA-ab was 0.66 (0.42-1.05), P = 0.078 and for YOP IgG-ab it was 0.95 (0.60-1.50), P = 0.816. "

01/01/1989 - "Comparison of the immunological assay data in complicated and uncomplicated yersiniosis shows equally high levels of IgG and CIC. "
10/01/2006 - "Within discordant twin pairs, the thyroid antibody-positive twin did not have an increased risk of Yersinia infection compared to the thyroid antibody-negative co-twin [odds ratio: YOP IgA-Ab: 0.94 (0.49-1.83), P = 0.866, and YOP IgG-Ab: 1.35 (0.72-2.53), P = 0.345]; 41% (95% CI 10-67% of the liability of being YOP antibody-positive was due to genetic effects. "
10/01/2006 - "Yersinia infection was not associated with a positive thyroid antibody status: the odds ratio (with 95% CI) for YOP IgA-ab was 0.66 (0.42-1.05), P = 0.078 and for YOP IgG-ab it was 0.95 (0.60-1.50), P = 0.816. "
09/01/1993 - "In contrast, immunoblots of patients with supposed chronic yersiniosis were characterized by a persisting IgA and elevated IgG reactivity. "
01/01/1981 - "enterocolitica LPS determinations, a anti-LPS antibodies of IgG class were present not only in yersiniosis but also in 16% of the RA patients."

04/19/2016 - "Hence, potentially this agent represents a valuable stepping stone for the development of novel therapeutics against Yersinia infections. "
01/01/2011 - "[Clinicoimmunological monitoring of therapy in patients with associated forms of yersiniosis]."
08/01/2000 - "Together, these data elucidate the possible early pathomechanisms operating in Yersinia infection and may have implications for the design of novel therapeutics directed against this enteropathogen."
11/23/1991 - "[Yersinia enterocolitica infections; clinical and histological characteristics, diagnosis and therapy]."
12/01/1990 - "[Clinical aspects, diagnosis and therapy of Yersinia enterocolitica infections]."

05/23/2013 - "In 6% of yersiniosis patients ≥5 years of age, appendectomies were performed. "
01/01/1983 - "Five of seven hospitalized patients had appendectomies before the disease was recognized as yersiniosis. "
05/23/2013 - "Appendectomies and post-infectious complications (ReA and EN) are more frequently reported in yersiniosis patients than in the reference group suggesting that they can be attributed to infections with Y. "
10/01/2019 - "Appendicitis with a Crohn's-like histological appearance generally raises concern for Crohn's disease, Yersinia infection, and interval appendectomy. "
05/21/1988 - "[Persistent fever after appendectomy, disclosing a Yersinia infection in a patient with hemochromatosis]."

02/01/1997 - "To update and summarise cases of transfusion-transmitted Yersinia enterocolitica infection in New Zealand and to evaluate critically suggested methods to reduce this rare but frequently fatal complication of blood transfusion. "
07/01/2019 - "Invasive Yersiniosis in a Pediatric Patient With β-Thalassemia Major: Acute Decompensation After Rapid Blood Transfusion."
02/01/1994 - "Three patients who were on regular blood transfusion and desferrioxamine developed Yersinia enterocolitica infection. "

01/01/2015 - "Moreover, current isolation procedures are time-consuming and expensive, thus leading to underestimates of the incidence of enteric yersiniosis, inappropriate prescriptions of antibiotic treatments, and unnecessary appendectomies. "

01/01/2003 - "From pig to pacifier: chitterling-associated yersiniosis outbreak among black infants."