Yaws

10/01/1977 - "By mass treatment of cases and contacts with penicillin, the programs against yaws have dramatically reduced the incidence of reported cases throughout the Western Hemisphere from greater than 44,000 cases per year during 1950-1954 to 437 cases in 1975. "
05/15/2003 - "Efficacy of a targeted, oral penicillin-based yaws control program among children living in rural South America."
10/01/1986 - "Finally, CoVF treatment did not reduce the ability of frambesia-immune hamsters cured of disease with penicillin to resist reinfection. "
05/01/1985 - "The availability and efficacy of penicillin led some to anticipate yaws eradication; this expectation was not met but rather induced a false sense of security. "
07/01/2015 - "pertenue enabled the development of animal models and the identification of an effective antibiotic treatment (i.e., penicillin) for yaws. "

08/01/2015 - "We conducted a study to assess the impact of mass treatment with 20 mg/kg azithromycin on yaws. "
05/01/2013 - "This study, conducted in 2012 in two districts of the Congo (Bétou and Enyellé), screened for yaws (endemic treponemiasis) that could be treated by a single dose of azithromycin. "
10/07/2015 - "Given the enormous genetic similarity that was recently revealed between TPA and TPE strains, there is a low but reasonable risk of emergence and spread of macrolide-resistant yaws strains following azithromycin treatment. "
10/01/2015 - "The finding that Haemophilus ducreyi causes lesions similar to yaws is particularly important and further work is needed to assess the effect of azithromycin on these lesions. "
10/01/2015 - "To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. "

04/01/2010 - "Intramuscular benzathine penicillin is the currently recommended treatment for yaws. "
09/01/1998 - "Thirty-nine children with clinical yaws (6% of 632 examined) were monitored clinically and serologically, for nearly two years after mass treatment of all villagers with the World Health Organization recommended dosages of benzathine penicillin. "
09/01/1954 - "The treponematosis control program of the World Health Organization; the treatment of yaws with benzathine penicillin G."
01/01/2011 - "A single intramuscular injection of benzathine penicillin is still effective in curing yaws. "
06/01/2011 - "To estimate failure rates after treatment with benzathine penicillin and to identify determinants of failure that affected outcomes for yaws, we conducted a cohort study of 138 patients; treatment failed in 24 (17.4%). "

05/15/2003 - "An observational study was conducted to determine the efficacy of oral penicillin V therapy in treating skin lesions of yaws in children. "

05/01/1985 - "In 1911 a campaign against yaws, probably the first such campaign in the world involving treatment with salvarsan, was organized. "
01/06/1912 - "SALVARSAN IN YAWS."
04/01/1911 - "THE TREATMENT OF YAWS (FRAMBOESIA) WITH ARSENOBENZOL (SALVARSAN)."
08/01/1911 - "2. On experimental and clinical grounds, it appears that yaws can be cured with a smaller dose of salvarsan than is necessary to cure syphilis. "

09/01/1953 - "[Trial of an abbreviated method of treatment of secondary yaws with procaine penicillin G; second communication]."
09/01/1953 - "[Trial of an abbreviated method of treatment of secondary yaws with procaine-penicillin G]."
01/01/1956 - "An analysis of the results of the treatment of yaws with a single injection of procaine penicillin with 2% aluminium monostearate."
02/28/1951 - "[Frambesia therapy with oil procaine-penicillin with aluminium stearate]."
02/01/1951 - "Preliminary and short reports; procaine penicillin in early yaws."

04/01/1979 - "Comparison of cardiolipin and treponemal tests in the serodiagnosis of yaws."
11/07/1959 - "Specificity studies with regard to syphilis and frambesia with original Wassermann reaction, cardiolipin-Wassermann reaction, pallida reaction, Meinicke clearance reaction, cardiolipin-micro flocculation and Treponema immobilization test]."
06/01/1952 - "Reactivity of cardiolipin antigens in yaws and in a random group of serums."
11/04/1950 - "[Comparative studies between complement fixation reaction and flocculation reaction (with cardiolipin) in the blood and cerebrospinal fluid in frambesia]."

04/01/1993 - "To study the localisation of treponemes and to analyse the inflammatory infiltrate in biopsy specimens from patients with primary or secondary syphilis, or early infectious yaws. "
04/01/1993 - "The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws."
07/01/1978 - "This pattern is the same as that seen in "framboesiform" secondary syphilis and in yaws."
01/08/1981 - "These facts are discussed and ascribed to tertiary syphilis rather than to congenital or secondary syphilis, to yaws or endemic syphilis."

03/01/1952 - "Quantitative study of the amino acids of the blood plasma of African patients afflicted with yaws."

04/30/1925 - "From a study of rabbits inoculated intratesticularly with two strains of treponemata derived from patients suffering from clinical yaws, it was found that a characteristic feature of the reaction to the infection was a well marked periorchitis of a granular or finely nodular type with or without a diffuse involvement of the tunic. "

01/01/2011 - "A single intramuscular injection of benzathine penicillin is still effective in curing yaws. "
01/28/2012 - "Children aged 6 months to 15 years with a serologically confirmed diagnosis of yaws were randomly allocated, by a computer-generated randomisation sequence, to receive either one 30 mg/kg oral dose of azithromycin or an intramuscular injection of 50,000 units per kg benzathine benzylpenicillin. "

05/17/1979 - "Nursing care study: a patient with yaws."

08/01/1911 - "1. Lesions of the testicle and scrotum of the rabbit produced by the treponema of syphilis and of yaws afford material for the study of chemotherapy, of serum reactions, and of immunity. "

03/15/2011 - "We describe the clinical and radiological manifestations and outcome after treatment of 7 children who received a diagnosis of early yaws osteoperiostitis. "
01/01/2011 - "Clinical outcome of skin yaws lesions after treatment with benzathinebenzylpenicillin in a pygmy population in Lobaye, Central African Republic."
07/01/1995 - "Fifteen children with clinical yaws were monitored for 9 months after treatment. "
04/01/1985 - "We tested 222 serum samples obtained from 51 patients presenting with syphilis, before and after treatment; 117 from 65 patients with a history of syphilis (114) or yaws (3); 77 from 71 patients with no evidence of syphilis; and 1117 serologically negative serum samples. "
06/01/2011 - "To estimate failure rates after treatment with benzathine penicillin and to identify determinants of failure that affected outcomes for yaws, we conducted a cohort study of 138 patients; treatment failed in 24 (17.4%). "

10/01/2013 - "In this review, we summarize current knowledge regarding the therapeutics of yaws and its diagnosis. "
08/01/1946 - "Interim notes on the therapeutics of bismuth, antimony, zinc, iron, and copper arsanilate in the treatment of malignant disease, syphilis, yaws, leprosy, tuberculosis, whooping cough and some minor complaints in the African."