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Juvenile Xanthogranuloma

Benign disorder of infants and children caused by proliferation of HISTIOCYTES, macrophages found in tissues. These histiocytes, usually lipid-laden non-Langerhans cells, form multiple yellow-red nodules most often in the skin, the eye, and sometimes in the viscera. Patients appear to have normal lipid metabolism and are classified as a normolipemic non-Langerhans cell histiocytosis.
Also Known As:
Xanthogranuloma, Juvenile; Juvenile Xanthogranulomas; Juvenile Xanthoma; Juvenile Xanthomas; Nevoxanthoendotheliomas; Xanthogranulomas, Juvenile; Xanthomas, Juvenile; Nevoxanthoendothelioma; Xanthoma, Juvenile
Networked: 111 relevant articles (8 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)
2. Erdheim-Chester Disease
3. Non-Langerhans-Cell Histiocytosis (Histiocytosis, Non Langerhans Cell)
4. Histiocytosis
5. Neoplasms (Cancer)

Experts

1. Sakamoto, Kenichi: 2 articles (04/2022 - 01/2021)
2. Shioda, Yoko: 2 articles (04/2022 - 01/2021)
3. Imashuku, Shinsaku: 2 articles (01/2020 - 06/2004)
4. Shields, Carol L: 2 articles (05/2015 - 03/2008)
5. Goerdt, Sergij: 2 articles (01/2014 - 01/2007)
6. Koukalová, R: 2 articles (06/2012 - 05/2012)
7. Krejčí, M: 2 articles (06/2012 - 05/2012)
8. Král, Z: 2 articles (06/2012 - 05/2012)
9. Mayer, J: 2 articles (06/2012 - 05/2012)
10. Pour, L: 2 articles (06/2012 - 05/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Juvenile Xanthogranuloma:
1. CladribineFDA LinkGeneric
2. Factor XIIIaIBA
3. Triamcinolone Acetonide (Azmacort)FDA LinkGeneric
4. SteroidsIBA
5. S100 Proteins (S 100 Protein)IBA
6. LipidsIBA
7. CholesterolIBA
8. AntigensIBA
03/01/2001 - "Juvenile xanthogranuloma: case report with immunohistochemical identification of early and late cytomegalovirus antigens."
12/01/1992 - "For example, the M phi s in cat-scratch fever are nearly unique in the expression of the "early inflammation" antigen identified by antibody 27E10, and the M phi s in juvenile xanthogranulomas, unlike those in most of the other conditions, lacked the antigen detected by antibody 25F9. "
12/01/1992 - "Using a large panel of monoclonal antibodies to monocyte/M phi-related antigens and a frozen-section immunoperoxidase technique, the following conditions were studied: granulomatous inflammation of unknown etiology, sarcoidosis, cat-scratch fever, toxoplasmosis, Gaucher's disease, and juvenile xanthogranulomas. "
06/01/2000 - "To explore the use of immunohistochemistry for this diagnostic problem, we examined the expression of S-100 protein, gp100 (the antigen recognized by HMB-45), tyrosinase (T311), Melan-A (A103), Factor XIIIa (FXIIIa), and CD68 in 10 juvenile xanthogranulomas (JXGs), five epithelioid histiocytomas (EHs), and 15 melanocytic nevi composed of large epithelioid cells. "
12/01/1987 - "Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 1-AT)] in biopsied tissues from histiocytosis X, juvenile xanthogranuloma, xanthoma tuberosum, xanthoma disseminatum, reticulohistiocytic granuloma and multicentric reticulohistiocytoma, all of which have been classified as histiocytic proliferative disorders. "
9. Clofarabine (Clolar)FDA Link
10. Phosphotransferases (Kinase)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. X-Ray Therapy
4. Keratectomy
5. Radiotherapy