HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Xanthine Oxidase

Subscribe to New Research on Xanthine Oxidase

An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.

Also Known As:

Hypoxanthine Dehydrogenase; Hypoxanthine-Xanthine Oxidase; Purine-Xanthine Oxidase; Dehydrogenase, Hypoxanthine; Hypoxanthine Xanthine Oxidase; Oxidase, Hypoxanthine; Oxidase, Hypoxanthine-Xanthine; Oxidase, Purine-Xanthine; Oxidase, Xanthine; Purine Xanthine Oxidase; Hypoxanthine Oxidase; Xanthine:oxygen oxidoreductase

Networked: 1505 relevant articles (69 outcomes, 158 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Alcohol Oxidoreductases: 1
      - Xanthine Oxidase: 1505

Experts

1.	Sultana, Sarwat: 17 articles (11/2011 - 04/2003)
2.	Hare, Joshua M: 11 articles (05/2015 - 04/2003)
3.	Khan, Naghma: 10 articles (11/2005 - 04/2003)
4.	Hosoya, Tatsuo: 8 articles (08/2015 - 06/2011)
5.	Yamamoto, Tetsuya: 8 articles (12/2014 - 09/2003)
6.	Johnson, Richard J: 6 articles (08/2015 - 12/2002)
7.	Fujimori, Shin: 6 articles (12/2014 - 06/2011)
8.	Ueda, Takanori: 6 articles (12/2014 - 06/2011)
9.	Struthers, Allan D: 6 articles (02/2012 - 07/2002)
10.	Landmesser, Ulf: 6 articles (09/2011 - 12/2002)

Related Diseases

1.	Ischemia 01/01/1994 - "of transport, deaminase and xanthine oxidase have been demonstrated to be effective in different animal models of ischemia. " 04/01/1993 - "Protective effects of therapy with a protease and xanthine oxidase inhibitor in short form pancreatic biliary obstruction and ischemia in rats." 09/01/1999 - "The purpose of this study was to investigate whether ischemia and subsequent reperfusion would affect xanthine oxidase activity in fetal rat brain capillaries. " 07/07/1993 - "This study looks at the role of xanthine oxidase (XO) in ischemia/reperfusion (I/R) induced intestinal mucosal damage using normal and xanthine oxidase deficient rats. " 04/01/1993 - "Subcellular distribution of xanthine oxidase during cardiac ischemia and reperfusion: an immunocytochemical study."
2.	Gout 03/15/2015 - "Xanthine oxidase (XO) inhibitors have been widely used for the treatment of gout. " 03/01/2015 - "The results demonstrate that UF-LC-MS combined with HSCCC might provide not only a powerful tool for screening and isolating xanthine oxidase inhibitors in complex samples but also a useful platform for discovering bioactive compounds for the prevention and treatment of gout." 01/01/2015 - "What are the effects of xanthine oxidase inhibitors to prevent gout in people with prior acute episodes? " 09/01/2014 - "We selected Pleurotus ostreatus from among several edible mushrooms because it has high anti-gout xanthine oxidase (XOD) inhibitory activity. " 09/01/2014 - "Characterization of an Anti-gout Xanthine Oxidase Inhibitor from Pleurotus ostreatus."
3.	Hyperuricemia 11/01/2008 - "The xanthine oxidase (XOD) inhibitory activity and anti-hyperuricemia effect in mice of Cinnamomum osmophloeum, which is an endemic tree in Taiwan, were evaluated in this study. " 03/13/2015 - "The attenuation of hyperuricemia-induced renal dysfunction was linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. " 02/23/2015 - "SLW at the dose of 125 mg/kg has proved to be active in reducing hyperuricemia and was capable to inhibit the hepatic xanthine oxidase enzyme (XOD). " 07/01/2014 - "Xanthine oxidase is considered as a potential target for treatment of hyperuricemia. " 07/01/2013 - "We have no information on medications used, such as xanthine oxidase, uricosuric drugs and hypotensives; therefore, the impact of hyperuricemia might be underestimated in our analysis. "
4.	Reperfusion Injury 09/01/1991 - "A blockade of the xanthine oxidase pathway for free radical generation could provide effective protection against ischemia/reperfusion injury. " 05/01/1997 - "Studies were conducted to determine the relevance of reperfusion injury in the juvenile pig, whose low levels of xanthine oxidase are similar to those of the human being. " 12/01/2015 - "Although all four enzymatic sources are present in most tissues and are likely to play some role in reperfusion injury, priority and emphasis has been given to specific ROS sources that are enriched in certain tissues, such as xanthine oxidase in the gastrointestinal tract and mitochondria in the metabolically active heart and brain. " 01/01/2002 - "These results support the pivotal role of intracellular ROS generated by xanthine oxidase in reoxygenated cell injury, and suggest the viability of using an intracellular antioxidative therapy for reperfusion injury of the liver." 06/01/1998 - "Other methods of determining xanthine oxidase activity that detect the enzyme in sloughed epithelial cells should be used to better define the importance of this pathway in jejunal reperfusion injury in horses."
5.	Body Weight (Weight, Body) 07/01/1990 - "No toxicity to mice was observed after i.v. injection of xanthine oxidase-antibody conjugate up to 2.9 U/kg body weight. " 01/01/1996 - "It was also observed that the activity of xanthine oxidase was significantly inhibited by administration of rebamipide at 60 mg/kg body weight, leading to a significant reduction of lipid peroxide content in alcohol-treated rats. " 02/01/1992 - "Inhibition or inactivation of xanthine oxidase activity was effective in reducing mucosal injury and bacterial translocation when zymosan was injected at 0.1 mg/g but not at 0.5 mg/g body weight. " 10/01/1994 - "A xanthine oxidase inhibition dose (< 10 mg/kg body weight) of allopurinol showed no effects on oxidative tissue damage in the model used in this study. " 07/01/2007 - "CsA administration (25 mg/kg body weight, orally, for 21 d) showed increased level of oxidants and xanthine oxidase activity. "

Related Drugs and Biologics

1.	Allopurinol (Remid)
2.	Uric Acid (Urate)
3.	Xanthine
4.	febuxostat
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Superoxides (Superoxide)
7.	purine
8.	Enzymes
9.	Deferoxamine (Desferal)
10.	Oxygen

Related Therapies and Procedures

1.	Ligation
2.	Free Tissue Flaps
3.	Kampo Medicine (Kampo)
4.	Resuscitation
5.	Oral Administration