Wound Infection (Wound Infections)

01/01/2023 - "This dual approach dramatically improved antibiotic efficacy against a methicillin-resistant Staphylococcus aureus (MRSA) wound infection in diabetic mice."
01/01/2012 - "Five novel antibiotic and manuka honey combinations were found that improved antibacterial effectiveness in vitro and these offer a new avenue of future topical treatments for wound infections caused by these two important pathogens."
01/01/1985 - "Because of the significant reduction of abdominal wound infections which could be achieved in treating patients (X2 = 6,56; p less than 0,05) with antibiotics, these medicaments should be given in emergency bowel surgery with a further prospective controlled study being not necessary."
01/01/2017 - "One patient had a minor wound infection treated successfully with oral antibiotics. "
08/01/2014 - "Complication rates are low and relate largely to localised wound infections, treated successfully with antibiotics. "

01/01/1983 - "A second trial revealed that intravenous metronidazole administered 1 hour before and at 8 and 16 hours after the operation provided similar protection against wound infection. "
08/01/1995 - "To compare the efficacy of rectal and intravenous metronidazole in the prevention of anaerobic wound infections after appendicectomy. "
06/01/1986 - "The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens."
06/01/1979 - "A double-blind trial of a single intravenous dose of metronidazole as prophylaxis against wound infection following appendicectomy."
01/01/2006 - "Wound infection after metronidazole infiltration."

09/09/2020 - "The antibacterial efficacy of the hydrogel was tested against two model bacteria, Staphylococcus aureus and Pseudomonas aeruginosa, two of the most commonly found bacteria in wound infections. "
11/08/2023 - "The ex vivo antibacterial efficacy of the F5 hydrogel formulation was also investigated in a pork skin wound infection model, where it significantly reduced the bacterial burden by 4.65 log. "
01/01/2021 - "Facile Synthesis of the Cu, N-CDs@GO-CS Hydrogel with Enhanced Antibacterial Activity for Effective Treatment of Wound Infection."
12/01/2017 - "Chronic wound infections can be effectively treated using hydrogel loaded with an extract from manuka honey. "
01/01/2021 - "Therefore, this novel multifunctional AgNP thermo-responsive hydrogel is potentially a safe and effective treatment at much lower concentration for the treatment of wound infections. "

02/01/2016 - "Local application of gentamicin significantly reduced incidence of wound infection following colorectal surgery in Western Europe, and it was also associated with lower risk of wound infection during follow-up period of 30 days. "
07/01/1976 - "Despire poor bile levels, gentamicin was associated with a significant reduction of wound infection from 22% to 6% and septicaemia from 14% to 2% compared with controls. "
05/01/2019 - "Randomised controlled studies (RCTs) and observational studies (OSs) that assessed the efficacy of topical gentamycin application on prophylaxis and treatment of local wound infection were included. "
01/01/2021 - "A Preliminary Exploration of the Efficacy of Gentamicin Sponges in the Prevention and Treatment of Wound Infections."
05/01/2019 - "The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta-analysis."

02/02/2022 - "In this systematic review, four studies with a total of 875 participants were included, of which two studies showed a significant reduction of wound infection rate using povidone-iodine (p=0.001 and p=0.03). "
11/01/2013 - "There was a reduced incidence of groin wound infections in those randomized to Betadine (3 versus 1), but this was not statistically significant (P = 0.4). "
10/01/1975 - "Interparietal instillation of povidone-iodine resulted in a statistically significant reduction in wound infection (P less than 0.01) in treated patients compared with untreated, randomized, matched controls. "
01/01/2006 - "Applying PVP-I was effective in eliminating skin contamination, as cultures became negative in all cases after applying PVP-I. However, this study could not demonstrate the reduction of wound infection or SSI in the group with PVP-I, possibly because the number of cases in this study was too small to make a difference. "
06/01/2002 - "The purpose of this study was to assess the influence of povidone-iodine mediastinal irrigation used for the treatment of deep sternal wound infection (DSWI) on thyroid function. "

04/01/2011 - "The objectives of this study were to evaluate the antimicrobial activity of honey against micro-organisms, to formulate a honey ointment and to evaluate the efficacy of such ointment by conducting clinical trials on skin wound infection. "
04/01/2011 - "Newly formulated ointment containing 20% active antimicrobial honey is very effective and alternative low-cost product for the treatment of wound infections."
04/01/2011 - "'Honey ointment': a natural remedy of skin wound infections."
02/10/2011 - "These plants have been used as traditional medicines by local ethnic groups, where they are prepared as decoction, pastes for wound infections, and some have been eaten as salad. "
02/01/2007 - "Wound infection was significantly less common in Alpha ointment group compared to the other two groups (p<0.05). "

04/01/2010 - "Prophylactic intranasal mupirocin is safe, inexpensive and effective in reducing the overall sternal wound infection after open-heart surgery. "
02/01/2008 - "Topical mupirocin application was effective against crush wound infections inoculated with S. "
10/01/1985 - "The efficacy of topically-applied mupirocin was evaluated against an experimental surgical staphylococcal wound infection in the guinea-pig. "
01/01/2020 - "The in vivo study was conducted on rat diabetic wound infection model that was infected by mupirocin-methicillin-resistant Staphylococcus aureus (MMRSA). "
07/01/2007 - "The purpose of this study was to investigate the mupirocin resistance in MRSA strains isolated from wound infections of in- and out-patients of two distinct hospitals located in Ankara and Istanbul. "

03/01/1981 - "The study shows that even a very short peroperative course of Cefoxitin is highly effective in reducing postoperative abdominal wound infections after elective colorectal surgery."
08/01/1982 - "A significant reduction in wound infection was evident in the cefoxitin-treated group (4.4 per cent) when compared with controls (16.7 per cent) (chi 2 = 6; P = 0.02). "
02/01/2001 - "Eleven women (4.6%) in the placebo group and eight (3.4%) in the cefoxitin group had microbiological evidence of wound infection. "
02/01/2001 - "Wound infection was the most common complication occurring in 13.3% and 12.5% of women in the placebo and cefoxitin groups, respectively. "
02/01/1994 - "Wound infection occurred in three patients, 2.4% of the cefoxitin group and in five patients (4%) of the second group (with no significant difference). "

01/01/1991 - "In conclusion, a single preoperative dose of 1 g cefazolin proved to be effective for reducing the wound infection rate in non-cardiac thoracic surgery."
07/01/2011 - "We conducted a prospective, randomized, double-blind, placebo-controlled trial comparing wound infection rates in 404 patients (203 received prophylactic cefazolin, 201 received a placebo) undergoing TIVAD insertion. "
10/20/2021 - "No statistically significant differences could be found in any of the primary endpoints, but there was a trend towards less deep sternal wound infections in the cefazolin group. "
02/01/2021 - "Wound infection following implant removal of foot, ankle, lower leg or patella; a protocol for a multicenter randomized controlled trial investigating the (cost-)effectiveness of 2 g of prophylactic cefazolin compared to placebo (WIFI-2 trial)."
11/01/2018 - "Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections."

01/01/2006 - "We conclude that topical plus systemic vancomycin treatment might be more effective in patients with deep sternal wound infections caused by methicillin-resistant S. "
11/01/2023 - "The risk of sternal wound infection was significantly reduced by almost 70% in the topical vancomycin group (risk ratios [95% confidence intervals]: 0.31 (0.23-0.43); P < .00001) and was comparable between randomized controlled trials (0.37 [0.21-0.64]; P < .0001) and observational studies (0.30 [0.20-0.45]; P < .00001; Psubgroup = .57). "
11/01/2023 - "Recent randomized controlled trials have also questioned the effectiveness of topical vancomycin in sternal wound infection prophylaxis. "
01/01/2023 - "Retraction note to: Treatment of methicillin resistant Staphylococcus aureus wound infection using vancomycin-loaded nanoparticles: An in vitro and in vivo study."
11/01/2014 - "Recent studies have shown that prophylactic use of intrawound vancomycin in posterior instrumented spine surgery substantially decreases the incidence of wound infections requiring repeat surgery. "

04/01/2011 - "aureus wound infection model provides a valuable preclinical screening method to investigate cutaneous immune responses and the efficacy of topical antimicrobial therapies."
10/01/2018 - "VSD therapy is an effective and safe adjunct to conventional treatment modalities for the management of refractory wound infection following RT."
01/01/2007 - "The use of VAC therapy is an effective and safe adjunct to conventional and established treatment modalities for the management of wound infection and dehiscence following RT. "
11/01/2002 - "The VAC system can be considered as an effective and safe adjunct to conventional and established treatment modalities for the therapy of sternal wound infections after cardiac surgery."
01/01/2022 - "This study sought to determine whether closed incision negative pressure therapy reduced wound infection and improved outcomes in cardiothoracic surgery. "

06/01/2010 - "There was a significant reduction in hospital stay in the study group compared to the control group (mean in days 9.1+/-2.3/12.3+/-7.6) (P<0.001) and also there was no wound infection compared to the control group (0/5 cases). "
07/01/2023 - "LA has significant benefits in treating PA and is associated with better post-operative outcomes such as shorter hospital stay, lower incidence of wound infection and other complications. "
12/01/2010 - "Length of time required for RAH was significantly longer then TAH in obese and morbidly obese patients, however benefits to patients of a minimally invasive approach included reduced incidence of wound infections, reduced transfusion rates, reduced blood loss, and shortened length of stay. "
09/23/2023 - "Additionally, NPWT was more effective in reducing deep wound infections (1.48% vs. 4.15%, OR: 0.36, 95% CI: 0.23-0.56, p < 0.001) and resulted in shorter hospital stays (SMD: -0.33, 95% CIs: -0.54 to -0.13, p = 0.001). "
04/01/2013 - "Compared with ODP, LDP showed statistically significant differences with respect to less blood loss, lower transfusion rates, lower wound infection rates, lower morbidity rates, and shorter hospital stays. "

10/02/1999 - "After wound infections that required no or only local treatment were excluded from the analysis, antibiotic prophylaxis remained highly effective in reducing clinically important wound infections (1/41 (2%) v 11/43 (26%), P<0.01) and non-wound infections (2 (5%) v 9 (21%), P<0.05). "
04/01/1996 - "As previous work has shown, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. "
08/01/1993 - "As has been proved before, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. "
04/01/2009 - "In particular, perhaps a sensible philosophy would be to assume that antibiotic prophylaxis is effective in reducing the risk of wound infection for all types of surgery, even ones where no clinical trial data exists and make exceptions to this rule if, for certain types of surgery, it can be proved to the contrary."
11/01/2001 - "Platt et al assessed the efficacy of preoperative antibiotic prophylaxis in a clinical trial of 1218 patients undergoing clean surgery with an absolute reduction rate of 39% in wound infections. "

01/15/2023 - "There were 2 patients (3.7%) in the study group and 3 patients (5.8%) in the control group with superficial wound infection, which were cured after debridement and dressing change. "
09/01/2021 - "Debridement and removal of exposed artificial graft are considered the gold standard for treating wound infection. "
12/01/2018 - "Deep sternal wound infection (DSWI) is a refractory complication after heart surgery, and debridement is the first-line treatment. "
01/01/2014 - "Superficial wound infection occurred in 3 cases, and was cured after debridement; the other incisions healed by first intention without complications. "
03/20/2010 - "Complications occurred in two patients: one had a transient weakness of the left side lower extremity and the symptom improved spontaneously without further treatment within one month; the other patient suffered a deep wound infection three weeks after the operation, and recovered well by additional debridement, continuous perfusion and drainage. "

01/01/2022 - "Incisional Negative Pressure Wound Therapy Is Protective Against Postoperative Cardiothoracic Wound Infection."
06/01/2015 - "Negative pressure wound therapy (NPWT) has been reported to be useful in the treatment of severe wound infections. "
02/01/2011 - "Negative-pressure wound therapy (NPWT) has been used for the treatment of deep sternal wound infection (DSWI) with promising results. "
01/01/2023 - "The results of recent studies regarding the efficacy of Negative Pressure Wound Therapy (NPWT) for the prevention of sternal wound infection (SWI) after adult cardiac surgery are not conclusive. "
07/22/2022 - "The results of current studies are not conclusive on the efficacy of incisional negative-pressure wound therapy (NPWT) for the prevention of sternal wound infection (SWI) after adult cardiac surgery. "