Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome)

A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Also Known As:
Wolf-Parkinson-White Syndrome; Syndrome, Wolff-Parkinson-White; Anomalous Ventricular Excitation Syndrome; Auriculoventricular Accessory Pathway Syndrome; False Bundle-Branch Block Syndrome; Syndrome, WPW; Syndrome, Wolf-Parkinson-White; Wolf Parkinson White Syndrome; Wolff Parkinson White Syndrome; WPW Syndrome
Networked: 677 relevant articles (47 outcomes, 51 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Atrial Fibrillation
2. Tachycardia (Tachyarrhythmias)
3. Supraventricular Tachycardia
4. Atrioventricular Nodal Reentry Tachycardia (AV Nodal Reentrant Tachycardia)
5. Atrial Flutter (Flutter, Atrial)


1. McKenna, William J: 3 articles (03/2012 - 02/2002)
2. Arad, Michael: 3 articles (10/2007 - 02/2002)
3. Brembilla-Perrot, B: 3 articles (08/2006 - 01/2006)
4. Carling, David: 3 articles (05/2006 - 12/2002)
5. Brembilla-Perrot, Béatrice: 2 articles (11/2013 - 09/2003)
6. Hirata, Yasunobu: 2 articles (01/2013 - 01/2010)
7. Choi, Eue-Keun: 2 articles (11/2011 - 11/2007)
8. Oh, Seil: 2 articles (11/2011 - 11/2007)
9. Siwińska, Aldona: 2 articles (01/2011 - 01/2007)
10. Bobkowski, Waldemar: 2 articles (01/2011 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wolff-Parkinson-White Syndrome:
1. Amiodarone (Amiodarona)FDA LinkGeneric
2. AdenosineFDA LinkGeneric
3. Flecainide (Tambocor)FDA LinkGeneric
4. Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
5. Propafenone (Rythmol)FDA LinkGeneric
6. Verapamil (Calan)FDA LinkGeneric
7. Ajmaline (Wolfina)FDA Link
8. Anti-Arrhythmia AgentsIBA
9. EncainideIBA
10. Procainamide (Procan)FDA LinkGeneric

Therapies and Procedures

1. Catheters
2. Electric Countershock (Cardioversion)
3. Electrodes (Electrode)
4. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
12/01/2000 - "We experienced the anesthetic management of a minimally invasive direct coronary artery bypass (MIDCAB) in a patient with Wolff-Parkinson-White (WPW) syndrome. "
07/15/2009 - "After excluding patients with anterior wall Q-wave MI (defined as the presence of a QS complex or Q-wave > or =1 mm deep in V(2) or V(3)), sudden unexpected death, MI after percutaneous coronary interventions or coronary artery bypass grafting during this hospitalization, Wolff-Parkinson-White syndrome, pacemakers, bundle branch blocks, and electrocardiograms that were of poor quality or affected by severe motion artifact, inconsistencies with patient identification, or errors in lead placement, 137 patients remained. "
03/01/2008 - "Other procedures were also carried out if appropriate, including bidirectional Glenn shunt in 1 patient with double outlet of right ventricle and pulmonary artery stenosis; interruption of accessory pathway in 1 patient with Wolff-Parkinson-White syndrome; coronary artery bypass graft in 5 with severe coronary artery disease; and atrial or ventricular repair in 4 with congenital septum defects. "
10/01/1993 - "Sotalol is effective in controlling paroxysmal supraventricular tachycardias and the ventricular response to atrial fibrillation/flutter in Wolff-Parkinson-White syndrome, in maintaining sinus rhythm after cardioversion of atrial fibrillation/flutter, and in preventing initiation of supraventricular tachyarrhythmias following coronary artery bypass surgery. "
05/22/2003 - "Extensive cost-effectiveness studies have been conducted on many important cardiovascular therapies: (1) beta-blockers and diuretics for multiple CVD outcomes, mortality, and prevention of recurrent myocardial infarction (MI); (2) statins for both primary and secondary prevention of CVD; (3) enalapril for prevention and treatment of congestive heart failure; (4) tissue plasminogen activator treatment of acute MI; (5) coronary artery bypass graft for left main, single-, and 2-vessel coronary artery disease, or severe angina; (6) physician counseling for smoking; and (7) radiofrequency ablation therapy for Wolff-Parkinson-White syndrome. "
5. Cryosurgery