White Muscle Disease

A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)

Also Known As:

Networked: 54 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stomach Ulcer (Gastric Ulcer)
2.	Necrosis
3.	Muscular Diseases (Myopathy)
4.	Muscular Dystrophies (Muscular Dystrophy)
5.	Vitamin E Deficiency

Experts

1.	Wan Abas, Wan Abu Bakar: 1 article (01/2013)
2.	Seifi, Hesam A: 1 article (01/2013)
3.	Osman, Noor Azuan Abu: 1 article (01/2013)
4.	Pingguan-Murphy, Belinda: 1 article (01/2013)
5.	Mohri, Mehrdad: 1 article (01/2013)
6.	Ataollahi, Forough: 1 article (01/2013)
7.	Wakshlag, J J: 1 article (12/2012)
8.	Korn, A E: 1 article (12/2012)
9.	Divers, T J: 1 article (12/2012)
10.	Mittel, L: 1 article (12/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to White Muscle Disease:

1.	SeleniumIBA 02/01/1989 - "Studies on serum selenium and tocopherol in white muscle disease of foal." 06/01/1975 - " Included in the study were 3 lactating ewes with lambs at foot and 3 lambs which had been weaned on to fodder low in selenium and were recovering from white muscle disease with Se therapy. " 06/01/2009 - "with the discovery of selenium deficiency causing "white muscle disease" in feedstock in the 1950s. " 03/01/2002 - "Lambs with white muscle disease and selenium content of soil and meadow hay in the region of Kars, Turkey." 08/01/2001 - "White muscle disease has been reported in young deer with blood and liver selenium concentrations of 84-140 nmol/l and 240-500 nmol/kg fresh tissue, respectively. "
2.	Vitamin EFDA LinkGeneric 09/01/1978 - "[Vitamin E prophylaxis of white muscle disease]." 09/01/1980 - "The effects of dietary selenium and vitamin E on avian white muscle disease as measured by both chemical and physical parameters." 07/01/1977 - "Three 2 X 2 factorial experiments were conducted with sheep fed purified diets to determine the effects of selenium and vitamin E on the incidence of white muscle disease (WMD) and blood components. " 04/01/1959 - "The use of antioxidants and vitamin E in preventing white muscle disease of lambs." 10/31/1958 - "Effects of selenium and vitamin E on white muscle disease."
3.	Glutathione PeroxidaseIBA 11/01/1989 - "At this time, mean red cell glutathione peroxidase activities in the supplemented and unsupplemented groups were 430 and 11 U g-1 haemoglobin, respectively, and clinical white muscle disease had been observed in the latter group. " 09/01/1989 - "A survey of erythrocyte glutathione peroxidase (GPx) activity was undertaken in a herd of crossbred cattle after 3 cases of white muscle disease had been diagnosed. " 08/01/1990 - "Studies on serum tocopherol and selenium levels and blood glutathione peroxidase activities in lambs with white muscle disease." 08/01/1989 - "Studies on serum tocopherol, selenium levels and blood glutathione peroxidase activities in calves with white muscle disease." 08/01/1990 - "For the investigation of the cause of white muscle disease (WMD), tocopherol (Toc) and selenium (Se) levels and blood glutathione peroxidase (GSH-Px) activities were examined using lambs with WMD and their ewes. "
4.	Troponin IIBA 01/01/2013 - "Evaluation of copper concentration in subclinical cases of white muscle disease and its relationship with cardiac troponin I." 01/01/2013 - "The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. " 06/01/2010 - "The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). "
5.	trans-crotonin (CTN)IBA 01/01/2013 - "The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. " 06/01/2010 - "The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). "
6.	Sodium Selenite (Selenite)IBA 02/01/1975 - "[Experience in the prevention of white muscle disease of lambs by means of sodium selenite]." 01/01/2010 - "Sodium selenite is used to prevent selenium deficiency known as nutritional muscular dystrophy or white muscle disease. " 01/01/2008 - "The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. "
7.	Troponin T (T, Troponin)IBA 06/01/2010 - "The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). "
8.	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/01/2008 - "The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. "
9.	CopperIBA 01/01/2013 - "Evaluation of copper concentration in subclinical cases of white muscle disease and its relationship with cardiac troponin I." 01/01/2013 - "The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. "
10.	Keshan diseaseIBA 04/01/2011 - "As an essential trace element, selenium (Se) deficiency results in White Muscle Disease in livestock and Keshan disease in humans. " 02/01/2006 - "Nutritional selenium deficiency is associated with Keshan disease in humans and white muscle disease in ruminant livestock. " 02/01/2002 - "A pure selenium deficiency is harmful to the heart and causes a fatal dilated congestive cardiomyopathy in animals (white muscle disease) and in man (Keshan disease). "

Therapies and Procedures

1.	Injections 06/01/1973 - "Efficacy of selenium and vitamin E injections in the prevention of white muscle disease in young swine."
2.	Aftercare (After-Treatment) 01/01/2008 - "The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. "
3.	Total Parenteral Nutrition 12/01/1999 - "White muscle disease in humans: myopathy caused by selenium deficiency in anorexia nervosa under long term total parenteral nutrition."
4.	Intramuscular Injections 07/01/2004 - "Comparative data on the influence of selenium and cobalt inorganic compounds and their chelate complexes with methionin along with intramuscular injection of the vitamin preparation "Ursovit" on metabolism and treatment of calves with the symptoms of white muscle diseases are given in the paper. "