Water Intoxication

03/01/2002 - "The present results suggest that glycerol hyperhydration prior to ODT in high ambient temperatures may provide some protection against the negative performance effects of competing in the heat."
10/01/2009 - "The goal of this article is to report on what is known and unknown about how glycerol-containing hyperhydration solutions (GCHSs) are processed at the stomach and intestine level, propose strategies to improve the efficacy of GIH, and provide research questions for future studies. "
06/01/1998 - "This study examined the efficacy of glycerol and water hyperhydration (1 h before exercise) on tolerance and cardiovascular strain during uncompensable exercise-heat stress. "
10/01/2009 - "Glycerol-induced hyperhydration (GIH) has been shown to improve fluid retention and endurance performance compared with water-induced hyperhydration. "
09/01/1998 - "Since 1987, glycerol ingestion with added fluid has been used to increase total body water (glycerol hyperhydration) by up to 700 ml, thereby providing benefits of improved thermoregulation and endurance during exercise or exposure to hot environments. "

12/01/2015 - "This case demonstrates that while oral sodium supplementation does not necessarily prevent symptomatic EAH associated with overhydration, early recognition and field management with oral hypertonic saline in combination with fluid restriction can be effective treatment for mild EAH. "
10/01/2015 - "Acute Sodium Ingestion Before Exercise Increases Voluntary Water Consumption Resulting In Preexercise Hyperhydration and Improvement in Exercise Performance in the Heat."
02/01/2020 - "Few ultramarathon runners recognize that supplementing sodium intake beyond that in food and drink is generally not necessary during ultramarathons or that it could result in overhydration. "
02/01/2020 - "Of those indicating that sodium supplements should not be made available, 85.0% indicated it is because runners can provide their own, 27.9% indicated it is because they are not necessary, and 12.1% indicated they could increase thirst drive and cause overhydration. "
01/01/2020 - "On the contrary, baseline overhydration or categorization by classic predictors of mortality (age, comorbidity, diabetes) did not appear to influence the risk pattern associated with lower serum sodium levels. "

10/01/2021 - "In conclusion, hyperhydration with forced diuresis combined with aggressive mesna dosing is an effective strategy in preventing severe PTCy-associated HC, subsequently preventing any negative impact on transplant outcome."
10/01/2021 - "Standard HC prophylaxis was hyperhydration with forced diuresis and mesna at 320% the daily dose of PTCy. "
02/01/2015 - "One hundred and forty-seven patients (93%) given high-dose CY were treated with hyperhydration combined with 2-mercaptoethane sulphonate (mesna) and diuresis alkalinization, and only 51 (32.3%) patients were preventively catheterized and received continuous bladder irrigation (CBI). "
11/01/1999 - "The cost of hyperhydration was US$ 20 per course as opposed to US$ 1,500 per course for mesna, based on acquisition costs at our institution. "
01/01/1993 - "Fifteen patients received MESNA (group A) and 25 did not (group B), and all received concomitant hyperhydration (3,000ml/m2/day). "

06/01/1983 - "Continued administration of vasopressin has relieved the symptoms and has not resulted in water intoxication."
12/01/1995 - "Antidiuretic hormone concentrations (ADH) were significantly reduced from prehyperhydration levels during both hyperhydration trials but tended (P = 0.07) to rise during GI compared with WI at the very time urine flow and free water clearance differences were also evident. "
01/01/2009 - "The plasma antidiuretic hormone level, which may be involved in the occurrence of water intoxication, was consistently low in this patient, and linked to type D syndrome of inappropriate antidiuretic hormone secretion, designated "hypovasopressinemic antidiuresis". "
03/01/2006 - "An overhydration technique was used before dosing to suppress endogenous vasopressin production and thereby ensure that any antidiuresis could be attributed to treatment. "
11/17/2002 - "In the evaluation of the results of the diagnostic procedures, it is to be considered that long-term overhydration of any origin suppresses the vasopressin secretion and the "washout" effect of the long-term water-diuresis decreases the concentration gradient of the renal medulla leading to blunted sensitivity towards vasopressin. "

09/01/1993 - "No cases of water intoxication and no significant shifts in electrolytes were reported in the four studies which measured them. "
06/01/2022 - "By contrast, hyperacute water intoxication may result from a large excess electrolyte-free water intake in such a short time that properly working urinary free water excretion mechanisms cannot cope. "
02/23/2018 - "The feto-maternal osmotic gradient favors water transport from the mother to the fetus and may increase the fetal risk of water intoxication when the mother ingests or is administered large volumes of electrolyte free solutions."
01/01/2015 - "We would therefore like to emphasize the importance of close assessment of electrolyte levels in patients with CVS to avoid water intoxication. "
01/01/2013 - "An electrolyte deficiency caused by de- or overhydration will not only limit human performance, but can also lead to serious health problems and death if left untreated. "

05/06/2019 - "The treatment does not compulsorily include washout by hyperhydration and diuretics. "
12/01/2014 - "Overhydration was greater in the diuretic group, but only to a nonsignificant degree (5.9 vs. 2.9%; P=.21). "
12/01/2000 - "Hyperhydration or increasing body water content above normal (euhydration) level was thought to have some benefit during exercise heat-stress; however, attempts to overdrink have been minimized by a rapid diuretic response. "
12/01/1991 - "Treatment of water intoxication due to diuretics."
11/01/1988 - "Dilutional hyponatraemia (water intoxication) must be prevented in patients with severe asthmatic attacks in whom diuretic capacity is impaired."

06/01/2007 - "Recently we experienced a case of water intoxication following low-dose intravenous cyclophosphamide. "
06/01/2007 - "Water intoxication following low-dose intravenous cyclophosphamide."
06/01/2000 - "Administering i.v. cyclophosphamide requires careful monitoring of fluid balance in order to avoid water intoxication. "
12/01/1997 - "The pathogenesis, clinical characteristics, treatment, and methods for prevention of cyclophosphamide induced water intoxication are discussed."
12/01/1997 - "Less well known is that water intoxication can develop even after low dose iv cyclophosphamide. "

01/01/2018 - "Total body water (TBW), overhydration (OH) and extracellular water (ECW) estimated by the BIA measurement in the attack group was significantly higher than that of the remission group and controls. "
11/10/2020 - "The primary aim of the present study was to analyze changes in post-dialysis (i.e., following removal of excess ECW) ECW, intracellular water (ICW), and the overhydration (OH) parameter over time. "
06/01/2018 - "A relative overhydration adjusted for extracellular water (OH/ECW) measured by bioimpedance >15% has shown an increased mortality risk in haemodialysis but few studies have been developed in advanced CKD. "
04/01/2013 - "Weekly Kt/V bis was 2.33 ± 0.68, and mean weekly Kt/V w was 2.20 ± 0.63 (p < 0.0001); 60.25 % of patients presented overhydration according to the BIS study (OH >1.1 l). "
01/01/2011 - "This randomized, controlled study was conducted to test if the recent use of overhydration value (OH) provided by bioimpedance spectroscopy and patients' education would help to control overhydration. "

05/01/2005 - "The aim of our study was to assess the diagnostic capabilities of multidetector CT in the evaluation of the small bowel in different pathological conditions, with the use of oral hyperhydration with isotonic solution. "
05/01/2018 - "If combined into a hyperhydration solution, their impact on fluid retention could potentially be greater than their singular effect. "
10/01/2016 - "Sixteen healthy males (age: 21 ± 2 years; fat-free mass (FFM): 65 ± 6 kg) underwent three, 3-hour long passive hyperhydration protocols during which they drank, over the first 60 minutes, 30-ml·kg FFM of an artificially sweetened solution. "
05/01/2005 - "Multidetector CT of the small bowel performed after oral hyperhydration with isosmotic solution, proved to be an accurate and thorough technique. "
05/01/2005 - "Multidetector CT of the small bowel: evaluation after oral hyperhydration with isotonic solution."

01/01/2012 - "One case of water intoxication seizure and one case of premature labour following the use of DDAVP was reported in a single study. "
10/01/1999 - "The objective of the present study was to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of desmopressin in healthy male subjects at different levels of overhydration. "
12/15/2022 - "With the subsequent diagnosis of water intoxication, the use of desmopressin was believed to have contributed to this serious complication. "
01/01/2020 - "Desmopressin is well tolerated by most patients, however adverse effects, such as hyponatraemia and water intoxication necessitate a strict fluid intake, thus motivating the search for alternative DI treatments. "
03/09/2018 - "This case describes an episode of iatrogenic water intoxication in a patient under desmopressin treatment. "

01/01/2019 - "In our experience, matured over 2 years in a cohort of prevalent patients, we observed a significant reduction of patient drop-out and technique failure, the number of scheduled and unscheduled hospital visits, the number of episodes of overhydration, rate of hospitalization, episodes of non-compliance to prescription, patient and hospital team time spent in travelling and management of therapy, healthcare costs and patient's expenditure, miles travelled by patients from home to hospital and vice versa. "
05/27/2023 - "Although no therapy is widely accepted as being able to prevent the development of HUS and its complications, several observational studies suggest that intravascular volume expansion (hyperhydration) may prevent end organ damage. "
03/05/2021 - "At this moment, the supportive therapies approved to treat included hyperhydration, forced diuresis and transfusion support. "
05/01/2015 - "Use of the device limits the volume of fluid dispensed during intravenous therapy and could potentially reduce the morbidity and mortality associated with overhydration in children receiving intravenous therapy. "
04/01/2014 - "Cornerstone of the treatment remains stone prevention with hyperhydration, urinary alkalization, and pharmacologic therapy. "

01/01/2016 - "For chemotherapy, he required hyperhydration, which posed a challenge because of severe hyponatraemia. "
08/01/1994 - "These results using aggressive hyperhydration and high volumes of continuous bladder irrigation are among the best reported following high-dose CY chemotherapy."
01/01/1987 - "Water intoxication associated with non-steroidal anti-inflammatory drug therapy."
04/24/1992 - "Stability of total parenteral nutrition supplied as 'all-in-one' for children with chemotherapy-linked hyperhydration."
01/01/2003 - "After standardization, body weight can safely be used as the only parameter for monitoring fluid retention in case of hyperhydration during chemotherapy."

01/01/2016 - "The purpose of our study was to assess overhydration in peritoneal dialysis patients using bioimpedance spectroscopy and to investigate whether overhydration is an independent predictor of mortality. "
03/01/2013 - "Our study demonstrates that overhydration is common in peritoneal dialysis patients. "
01/01/2022 - "Peritoneal dialysis (PD) has been part of the management of such patients mainly for promoting ultrafiltration and management of overhydration independently of kidney function. "
02/01/2021 - "Overhydration is a major cause of technique failure of peritoneal dialysis (PD). "
01/01/2020 - "The majority of patients undergoing peritoneal dialysis (PD) suffer from volume overload and this overhydration is associated with increased mortality. "

01/01/2003 - "Although the magnitude of hypohydration was modest (<3%), sprint times were significantly slower after the EID ( P<or= 0.05) compared with post hyperhydration and post rehydration but were not significantly different between trials. "
01/01/2021 - "This article reviews this topic and identifies benefits of adjusting maintenance fluid therapy to meet lower demands from gastrointestinal function, such as reduced volumes, lower cost, avoidance of overhydration."
04/25/2019 - "This suggests that LUS may provide a safety threshold to conduct fluid therapy and to avoid overhydration. "
12/01/2015 - "We recommend the use of the standing rehydration method because (1) the correct rehydration time can be evaluated by measuring water potential, (2) overhydration effects were smallest, and (3) π can be accurately corrected by using osmometric methods to estimate apoplastic water dilution. "
05/01/2015 - "Maji: a new tool to prevent overhydration of children receiving intravenous fluid therapy in low-resource settings."

07/01/1987 - "The study indicates that: hemofiltration may be a short-term treatment for refractory cardiac insufficiency with overhydration; a filtration rate of 500 ml/hour is effective and safe; and the central venous pressure may be a reliable guide to volume subtraction."
01/01/1989 - "Intraoperative hemofiltration for the prevention of hyperhydration]."
11/01/1978 - "The main advantages of chronic hemofiltration are the comfort of the patient and the ease in handling excess overhydration without extending treatment time, which is less than 3 X 3 hours/week if adequate hemofilters are used. "
12/01/1983 - "[Therapy of conventionally uncontrollable hyperhydration with hemofiltration]."
04/17/1977 - "[Hemofiltration - a new procedure for the treatment of uremia and hypotonic hyperhydration]."