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Warfarin (Coumadin)

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Also Known As:

Coumadin; Warfarin Sodium; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; Aldo Brand of Warfarin Sodium; Aldocumar; Antigen Brand of Warfarin Sodium; Apo-Warfarin; Apotex Brand of Warfarin Sodium; Bailly Brand of Warfarin Sodium; Boots Brand of Warfarin Sodium; Bristol-Myers Squibb Brand of Warfarin Sodium; Coumadine; Estedi Brand of Warfarin Sodium; Gen-Warfarin; Genpharm Brand of Warfarin Sodium; Goldshield Brand of Warfarin Sodium; Marevan; Tedicumar; Warfant; Warfarin Potassium; Potassium, Warfarin; Sodium, Warfarin; 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-

Networked: 8109 relevant articles (661 outcomes, 1523 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- Pyrans: 5
  - Benzopyrans: 11
    - Coumarins: 240
      - 4-Hydroxycoumarins: 2
        Warfarin: 8109
        Warfarin syndrome: 41
        7-hydroxywarfarin: 5
        6-hydroxywarfarin: 2
        10-hydroxywarfarin: 1
        8-hydroxywarfarin: 1
        coumafuryl: 1
        3'-hydroxywarfarin
        3-(1-(4-aminophenyl)-3-oxobutyl)-4-hydroxy-2H-1-benzopyran-2-one
        4'-hydroxywarfarin
        6-methyl-6,12-methano-6H,12H,13H-benzopyran(4,3-d)benzodioxocin-13-one
        azidowarfarin
        methylsulfinylwarfarin
        N-acetyl-gamma-glutamyl-4'-aminowarfarin
        warfarin drug combination pindone
        warfarin hexadecyl ether
- 2-Ring Heterocyclic Compounds
  - Benzopyrans: 11
    - Coumarins: 240
      - 4-Hydroxycoumarins: 2
        Warfarin: 8109
        Warfarin syndrome: 41
        7-hydroxywarfarin: 5
        6-hydroxywarfarin: 2
        10-hydroxywarfarin: 1
        8-hydroxywarfarin: 1
        coumafuryl: 1
        3'-hydroxywarfarin
        3-(1-(4-aminophenyl)-3-oxobutyl)-4-hydroxy-2H-1-benzopyran-2-one
        4'-hydroxywarfarin
        6-methyl-6,12-methano-6H,12H,13H-benzopyran(4,3-d)benzodioxocin-13-one
        azidowarfarin
        methylsulfinylwarfarin
        N-acetyl-gamma-glutamyl-4'-aminowarfarin
        warfarin drug combination pindone
        warfarin hexadecyl ether

Experts

1.	Lip, Gregory Y H: 129 articles (01/2016 - 01/2002)
2.	Wallentin, Lars: 57 articles (01/2016 - 05/2003)
3.	Singer, Daniel E: 55 articles (12/2015 - 03/2003)
4.	Eikelboom, John W: 53 articles (11/2015 - 07/2003)
5.	Hylek, Elaine M: 52 articles (01/2016 - 03/2003)
6.	Halperin, Jonathan L: 45 articles (12/2015 - 05/2003)
7.	Lopes, Renato D: 44 articles (01/2016 - 08/2009)
8.	Connolly, Stuart J: 43 articles (10/2015 - 03/2003)
9.	Ezekowitz, Michael D: 41 articles (10/2015 - 01/2002)
10.	Granger, Christopher B: 39 articles (01/2016 - 05/2008)

Related Diseases

1.	Stroke (Strokes) 12/01/2013 - "Warfarin anticoagulation is highly effective for stroke prevention in AF patients, but is underutilized especially in the elderly. " 01/01/2013 - "Warfarin therapy administered concomitantly with an antiplatelet agent dramatically reduced the incidence of ischemic stroke associated with postoperative PAF." 10/01/2012 - "In the general population, warfarin is highly effective for prophylaxis of ischaemic stroke, and though warfarin use likely increases the risk of intracranial haemorrhage, the absolute increase in risk is small. " 08/01/2011 - "Warfarin is the most widely used antithrombotic therapy for stroke prophylaxis for last several years, and now dabigatran (150 mg b.i.d.) is more effective than warfarin in stroke prevention in individuals at increased of stroke. " 03/01/2010 - "Warfarin is an anticoagulant effective in preventing stroke, but it has a narrow therapeutic range requiring optimal adherence to achieve the most favorable effects. "
2.	Atrial Fibrillation 10/15/2011 - "Warfarin is a complex but highly effective treatment for decreasing thromboembolic risk in atrial fibrillation (AF). " 07/01/2005 - "Although highly effective in preventing thromboembolic events among patients with atrial fibrillation, warfarin therapy is limited by a multitude of potential problems. " 01/01/2013 - "Despite the proven efficacy of warfarin, its use in patients with Atrial Fibrillation (AF) is reportedly low. " 03/01/1992 - "Three randomised studies of primary prevention have shown a significant reduction of the embolic risk in non-valvular atrial fibrillation treated by warfarin compared to patients on placebo. " 04/01/2012 - "Long-term anticoagulation with warfarin is the mainstay of treatment in patients with diseases with high thromboembolic potential, such as atrial fibrillation. "
3.	Hemorrhage 09/01/2015 - "Dabigatran seems to be as effective and safe as warfarin, although most data are from single-center studies, with small samples and very low overall bleeding and thromboembolic complications. " 04/01/2013 - "Warfarin therapy, if used appropriately, is highly effective in preventing thromboembolic events, but is simultaneously burdened by a narrow therapeutic window, multiple food and drug interactions, and a substantial bleeding risk. " 04/06/2011 - "Extending warfarin therapy is highly effective in preventing recurrences but is associated with increased rates of major and minor bleeding. " 05/23/2005 - "Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded fear of bleeding. " 07/01/1997 - "This audit of hospice inpatients taking warfarin showed a high incidence of bleeding which was possibly improved with very stringent international normalized ratio (INR) monitoring: 15 episodes in 17 patients improved to 11 episodes in 18 patients. "
4.	Thrombosis (Thrombus) 01/01/1999 - "Warfarin is very effective in preventing exacerbation of portal vein thrombosis in PNH." 10/01/2008 - "To evaluate the efficacy of prophylactic use of warfarin in patients with high risk of lead-associated thrombosis. " 03/22/2006 - "Here is a case where the right coronary artery is filled with thrombus and has been successfully treated with warfarin." 09/18/2003 - "Our objective was to show that high-intensity warfarin was more effective in preventing thrombosis than moderate-intensity warfarin. " 11/30/1999 - "Continued medication with warfarin during pregnancy will offer her a reasonable good protection against thrombosis, but carries a considerable risk of teratogenic effects. "
5.	Venous Thrombosis (Deep-Vein Thrombosis) 10/13/1997 - "Treatment with warfarin was most effective in preventing recurrent arterial and venous thrombosis. " 01/01/2004 - "In low risk patients who have not previously failed warfarin, moderate intensity anticoagulation (target international normalized ratio [INR] 2.5) is as effective as, and safer than, high intensity anticoagulation (INR 3.5), at least for patients with venous thrombosis. " 11/21/1987 - "The lack of disturbance of normal haemostasis at the time of operation together with a significant reduction in deep vein thrombosis may encourage surgeons to introduce minidose prophylaxis with warfarin." 10/01/1989 - "Finally, recent studies have shown that lower doses of warfarin than previously recommended are protective against recurrent venous thrombosis and have a reduced risk of hemorrhagic complications." 04/01/1994 - "This pilot study compared the efficacy of a fixed 2 mg/d dose of warfarin versus an adjusted higher dose of warfarin for 1 month after discharge to prevent the development of proximal leg deep venous thrombosis among recently discharged orthopedic patients. "

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