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Vulvar Neoplasms (Vulvar Cancer)

Subscribe to New Research on Vulvar Neoplasms

Tumors or cancer of the VULVA.

Also Known As:

Vulvar Cancer; Cancer of the Vulva; Neoplasms, Vulvar; Vulva Cancer; Vulva Neoplasms; Cancer, Vulva; Cancer, Vulvar; Cancers, Vulva; Cancers, Vulvar; Neoplasm, Vulva; Neoplasm, Vulvar; Neoplasms, Vulva; Vulva Cancers; Vulva Neoplasm; Vulvar Cancers; Vulvar Neoplasm; Cancer of Vulva

Networked: 400 relevant articles (18 outcomes, 65 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Vulvar Neoplasms (Vulvar Cancer)
3.	Thrombocytosis (Thrombocythemia)
4.	Anemia
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma)

Experts

1.	van der Zee, A G J: 9 articles (08/2015 - 08/2003)
2.	Beriwal, Sushil: 7 articles (06/2015 - 04/2006)
3.	Reinthaller, Alexander: 7 articles (09/2014 - 06/2005)
4.	Grimm, Christoph: 7 articles (09/2014 - 03/2004)
5.	de Hullu, J A: 7 articles (06/2009 - 12/2001)
6.	Oonk, M H M: 6 articles (08/2015 - 10/2006)
7.	Mahner, Sven: 6 articles (03/2015 - 05/2010)
8.	Woelber, Linn: 6 articles (03/2015 - 05/2010)
9.	Hefler, Lukas A: 6 articles (04/2008 - 03/2004)
10.	Sukumvanich, Paniti: 5 articles (06/2015 - 05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vulvar Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 10/01/2011 - "[A case of stage IVb vulvar cancer effectively treated by concurrent chemoradiotherapy with cisplatin]." 07/01/1989 - "A case of advanced cancer of the vulva that was treated by cisplatin with good result, is reported. " 01/01/2005 - "Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases." 08/01/2009 - "In this study, we evaluated the efficacy of celecoxib, a selective COX-2 inhibitor, as a chemosensitizing agent with cisplatin in vulvar cancer cells A431 and SW962. " 01/01/2014 - "The present single-institution trial aimed to evaluate the efficacy and toxicity of paclitaxel and cisplatin in locally advanced vulvar cancer. "
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/01/2002 - "Although associated with impaired disease-free and overall survival, pre-treatment serum concentrations of VEGF are not an independent predictor of outcome in patients with vulvar cancer. " 10/01/1999 - "Although associated with impaired disease-free and overall survival, pretreatment serum concentrations of VEGF are not an independent predictor of outcome in patients with vulvar cancer." 10/01/1999 - "The aim of the present study was to evaluate serum concentrations of vascular endothelial growth factor (VEGF) in patients with vulvar cancer and healthy female controls with respect to correlation of VEGF with clinicopathological parameters and impact on the patients' prognosis. " 01/01/2003 - "Expression profile of aforementioned genes indicated a definitive relationship between vascular endothelial growth factor isoform and vulvar cancer. " 08/01/2000 - "VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. "
3.	squamous cell carcinoma-related antigenIBA 06/21/1999 - "In summary, our data indicate that serum concentrations of SCC-Ag may be an additional independent prognostic factor of disease-free and overall survival in patients with vulvar cancer." 09/01/2002 - "In this retrospective trial, preoperative serum levels of SCC-Ag in 29 patients with invasive squamous cell vulvar cancer (pT1 + 2) were evaluated and compared with nodal status. " 06/01/2005 - "SCC-Ag serum levels cannot be used as an additional prognostic parameter in patients with surgically treated early stage vulvar cancer." 06/01/2005 - "Mean (standard deviation) SCC-Ag serum levels in patients with vulvar cancer were 1.5 (1.99) ng/mL. SCC-Ag serum levels were significantly higher in patients with pT2 vulvar cancer (2.2 [2.6] ng/mL) compared with patients with pT1 vulvar cancer (1.0 [1.2] ng/mL, P = 0.034). " 06/01/2005 - "SCC-Ag serum levels were measured preoperatively in 61 surgically staged patients with squamous cell vulvar cancer (UICC pT1 and pT2). "
4.	VaccinesIBA 03/01/2011 - "The vaccines have been demonstrated to be highly effective in preventing cervical dysplasia, vulvar cancer, and genital warts related to HPV types 6, 11, 16, and 18; they are most effective, however, in vaccinees who have never been infected with HPV. " 12/01/2007 - "The spectrum of HPV types found in vulvar squamous cell carcinomas indicates that the efficacy of HPV vaccination in preventing vulvar cancer might be diminished in the studied population, because the recently developed prophylactic vaccines are targeted against a limited number of HPV types."
5.	Hemoglobins (Hemoglobin)IBA 12/01/2010 - "Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue." 09/01/2000 - "The aim of our study was to determine the prevalence of tumor anemia and thrombocytosis in patients with vulvar cancer, and to evaluate the prognostic value or pretreatment hemoglobin (Hb) and platelet count regarding disease-free and overall survival of patients with vulvar cancer. "
6.	Topotecan (Hycamtin)FDA LinkGeneric 07/01/2012 - "This study reports our experience with an unconventional schedule of neoadjuvant chemotherapy (topotecan and cisplatin) without radiotherapy in a patient with locally advanced vulvar cancer (International Federation of Gynecology and Obstetrics stage IIIA) who experienced complete clinical remission, followed by minimal surgical treatment."
7.	celecoxib (Celebrex)FDA Link 08/01/2009 - "Taken together, celecoxib could be used as a chemosensitizing agent in vulva cancer cells; the anticancer activity of celecoxib seemed to be independent of COX." 08/01/2009 - "In this study, we evaluated the efficacy of celecoxib, a selective COX-2 inhibitor, as a chemosensitizing agent with cisplatin in vulvar cancer cells A431 and SW962. " 08/01/2009 - "Celecoxib potentiates the anticancer effect of cisplatin on vulvar cancer cells independently of cyclooxygenase."
8.	iso-sulfan blue (Lymphazurin)FDA LinkGeneric 02/01/1999 - "We did a prospective study to determine whether lymphazurin dye could identify sentinel lymph nodes in patients with cervical, uterine, and vulvar cancer. " 06/01/2003 - "Tc-99m sulfur colloid is superior to isosulfan blue dye in the detection of sentinel nodes in inguinal dissections of patients with vulvar cancer. "
9.	MicroRNAs (MicroRNA)IBA 12/01/2015 - "Therefore, this miRNA-specific sponge may be developed into a novel therapeutic treatment for patients with vulvar cancer. " 12/01/2015 - "Thus, a microRNA (miRNA) sponge for the miR-17 miRNA family was designed, synthesized and validated in vitro in order to explore a new therapeutic strategy based on inhibiting this oncogenic miRNA family in vulvar cancer. "
10.	Technetium Tc 99m Sulfur Colloid FDA Link 06/01/2003 - "Tc-99m sulfur colloid is superior to isosulfan blue dye in the detection of sentinel nodes in inguinal dissections of patients with vulvar cancer. "

Therapies and Procedures

1.	Radiotherapy 01/01/2000 - "Based on these results, the best treatment alternative for advanced vulvar cancer is wide local excision plus radiotherapy, as this method retains the high survival of traditional therapy but has less morbidity." 09/01/2015 - "Treatment outcomes of curative radiotherapy in patients with vulvar cancer: results of the retrospective KROG 1203 study." 01/01/2009 - "A survey was developed and distributed to representatives of the member study groups of the GCIG, targeting the use of radiotherapy (RT) in vulvar cancer. " 01/01/2000 - "This study was undertaken to evaluate the long-term results of radiotherapy with or without surgery in the management of advanced vulvar cancer. " 09/01/2015 - "We evaluated the prognostic factors and clinical outcomes of 56 patients with vulvar cancer treated with curative radiotherapy (RT) or concurrent chemoradiotherapy. "
2.	Adjuvant Radiotherapy 06/01/2012 - "Most vulvar cancers are diagnosed at a localized stage and can be cured with surgery and adjuvant radiotherapy. " 03/01/2015 - "This large multicenter study in vulvar cancer observed that adjuvant radiotherapy was associated with improved prognosis in node-positive patients and will hopefully help to overcome concerns regarding adjuvant treatment. " 08/01/2009 - "The aim of the study was to analyze the benefit from adjuvant radiotherapy in patients with vulvar cancer and a single positive node without extra capsular spread. " 06/01/2015 - "The NCDB was queried for vulvar cancer patients diagnosed from 1998-2011 who underwent extirpative surgery with confirmed inguinal nodal involvement treated with adjuvant radiotherapy. " 03/01/2012 - "However, information regarding the impact of the number of positive nodes in vulvar cancer is inconsistent, and so are recommendations when to apply adjuvant radiotherapy. "
3.	Drug Therapy (Chemotherapy) 07/01/2012 - "Complete remission after neoadjuvant chemotherapy of an advanced vulvar cancer patient: a case report." 12/01/2015 - "The primary endpoint of this trial was to assess clinical response (cCR) of squamocellular vulvar cancer (V-SCC) in elderly patients treated with electro-chemotherapy (ECT). " 12/01/2015 - "Palliative electro-chemotherapy in elderly patients with vulvar cancer: A phase II trial." 05/01/2008 - "The purpose of the study was to assess the clinical outcome in patients with locally-advanced vulvar cancers treated using preoperative chemotherapy with IMRT. " 03/01/2013 - "Chemotherapy of vulvar cancer: a review."
4.	Adjuvant Chemotherapy 11/01/2015 - "The panel reviewed the pertinent literature in vulvar cancer and voted on three variants to establish appropriate use of imaging, adjuvant radiation, including dose, fields, and technique, as well as adjuvant chemotherapy. " 06/01/2015 - "In a large population-based analysis, adjuvant chemotherapy resulted in a significant reduction in mortality risk for node-positive vulvar cancer patients who received adjuvant radiotherapy." 06/01/2015 - "Impact of adjuvant chemotherapy with radiation for node-positive vulvar cancer: A National Cancer Data Base (NCDB) analysis."
5.	Lymph Node Excision (Lymph Node Dissection) 08/01/2015 - "In 2008, the first Groningen International Study on Sentinel nodes in Vulvar cancer (GROINSS-V) showed that omission of inguinofemoral lymphadenectomy is safe in patients with early-stage vulvar cancer and a negative sentinel node and it simultaneously decreases treatment-related morbidity. " 08/01/2015 - "A large observational study is currently evaluating the outcomes of patients with early-stage vulvar cancer according to the results of their SLN biopsy and the approach to their care; this study may confirm that full inguinofemoral lymphadenectomy is no longer necessary in most patients with this disease. " 02/01/2015 - "The purpose of this study is to assess the cost and effectiveness of SLNB compared to universal inguinofemoral lymphadenectomy (LND) for vulvar cancer. " 01/01/2015 - "To systematically review previous studies and to evaluate the feasibility and safety of video endoscopic inguinal lymphadenectomy (VEIL) in vulvar cancer. " 10/01/2014 - "The objective of this study was to determine the costs and outcomes of inguinal-femoral lymph node dissection (IF-LND) versus sentinel lymph node biopsy (SLNB) for the management of early-stage vulvar cancer. "