Vitamin E Deficiency

A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)

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Networked: 941 relevant articles (30 outcomes, 84 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neurologic Manifestations (Neurological Manifestations)
2.	Cholestasis
3.	Muscular Dystrophies (Muscular Dystrophy)
4.	Infections
5.	Nervous System Diseases (Neurological Disorders)

Experts

1.	Traber, Maret G: 13 articles (11/2021 - 12/2004)
2.	Bertoni-Freddari, Carlo: 7 articles (12/2004 - 05/2002)
3.	Fattoretti, Patrizia: 7 articles (12/2004 - 05/2002)
4.	Arai, Hiroyuki: 6 articles (11/2021 - 04/2010)
5.	Rüstow, Bernd: 5 articles (03/2008 - 06/2002)
6.	Finno, C J: 4 articles (01/2022 - 11/2011)
7.	Kono, Nozomu: 4 articles (11/2021 - 01/2012)
8.	Rino, Yasushi: 4 articles (02/2017 - 02/2005)
9.	Shea, Thomas B: 4 articles (02/2006 - 01/2003)
10.	Casoli, Tiziana: 4 articles (06/2004 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vitamin E Deficiency:

1.	Vitamin EFDA LinkGeneric 10/01/1989 - "It appears that parenteral vitamin E administration may be suitable for therapeutic treatment of vitamin E deficiency in the black rhinoceros." 01/01/2020 - "These results suggest development of appropriate strategies to increase the levels of vitamin E in breast milk that may help to prevent and treat vitamin E deficiency." 04/01/1997 - "In addition, vitamin E supplementation (450 mg/kg diet) decreased the incidence of hepatic apoptosis, while vitamin E deficiency (0 mg/kg diet) increased the incidence of hepatic apoptosis. " 10/01/2022 - "Vitamin E is essential for health, and although vitamin E deficiency seems rare in humans, studies on estimates of dietary intake are lacking. " 01/01/2017 - "In conclusion, this study indicated that dietary vitamin E deficiency depressed fish growth, impaired the immune function and disturbed the structural integrity of the head kidney, spleen and skin in grass carp, but optimal vitamin E supplementation can reverse those negative effects in fish. "
2.	alpha-TocopherolFDA Link 10/01/1999 - "In the isolated vitamin E deficiencies gene mutation has been cleared for alpha-tocopherol transferprotein. " 08/01/1985 - "We undertook to determine the efficacy of intravenous alpha-tocopheryl acetate in rapidly correcting the vitamin E deficiency of the premature infant. " 09/01/1994 - "The mechanism for the decrease in alpha-tocopherol in conjunction with the increase in BC will require further study in order to develop strategies which will prevent vitamin E deficiency in BC-supplemented individuals." 01/01/2021 - "Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. " 01/01/2008 - "The most studied of these is alpha-tocopherol (alpha-TOH), because this form is retained within the body, and vitamin E deficiency is corrected with this supplement. "
3.	AntioxidantsIBA 10/01/1980 - "Synthetic antioxidants were effective in alleviating the vitamin E deficiency symptoms in the chicks fed UFA and DLS + UFA, while only slightly effective in those given DLS. " 01/01/1994 - "A rat model of chronic vitamin E deficiency has been used to study the effects of antioxidant depletion on jejunal structure and function in vitro. " 09/01/2011 - "Human symptoms of vitamin E deficiency suggest that its antioxidant properties play a major role in protecting erythrocyte membranes and nervous tissues. " 12/01/2006 - "Vitamin E deficiency in rats led to a sequence of antioxidant defense adaptations in the liver. " 05/15/2001 - "It is unclear if temporary vitamin E deficiency exhibits deleterious consequences or can be compensated for by other cellular antioxidants. "
4.	SeleniumIBA 07/01/1982 - "Comparative efficacy of five supplementation procedures to control selenium-vitamin E deficiency in swine." 09/01/1977 - "Efficacy of supplements in prevention of selenium-vitamin E deficiency in swine." 08/15/2007 - "Studies of RNA viruses (e.g., coxsackievirus B and influenzavirus) have shown that selenium or vitamin E deficiency in mice increases disease severity and results in stable genomic changes in the virus that increase virulence. " 06/01/2001 - "The diets used in this study induced selenium and vitamin E deficiencies in guinea pigs. " 05/01/1977 - "A correlative study of hepatic selenium levels and depletion rates with the onset of selenium-vitamin E deficiency disease in the chick."
5.	LipofuscinIBA 01/01/1967 - "[Studies on the quantitative distribution of lipofuscin and vitamin E deficiency-pigment in nerve cells of rats of various age groups]." 01/01/2020 - "Brown bowel syndrome (BBS) is a rare condition associated with vitamin E deficiency and defined by prominent lipofuscin deposition in the muscularis propria. " 01/01/2014 - "Vitamin E deficiency can lead to formation of lipofuscin aggregates. " 01/14/1994 - "There was no statistically significant effect of vitamin E deficiency or supplementation on lipofuscin accumulation with age as compared with the control rats in all three brain regions of old rats. " 01/01/1987 - "There was no significant difference in the concentration of lipofuscin in the SON neurons after vitamin E deficiency but there was a significant increase in the adrenal cortical cells. "
6.	tocophersolanIBA 11/01/1987 - "A chronic oral dose of 15-25 IU/kg.day of TPGS corrected the biochemical vitamin E deficiency state over 1-19 mo (mean, 10.6 mo) of TPGS therapy. " 12/01/2016 - "Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children With Chronic Cholestasis." 06/01/1993 - "Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis." 12/01/1987 - "We studied the effect of TPGS therapy on the neurologic function in 12 children with vitamin E deficiency (aged 9 months to 6 years) with prolonged forms of neonatal cholestasis. " 03/15/2017 - "PEGylated α-tocopherol, commercially known as Vitamin E TPGS, has been used as an emulsifier and therapeutic agent for children with vitamin E deficiency. "
7.	VitaminsIBA 04/22/2019 - "The pre-existing vitamin level in milk and diet are determinants for the efficacy of supplementation in milk, suggesting that in populations with vitamin E deficiency, high-dose supplementation can be used to restore its level in milk." 12/01/2015 - "Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and especially the cerebellum, from oxidative damage and motor coordination deficits. " 10/01/1992 - "Studies of vitamin E deficiency and supplementation strongly suggest that this vitamin is of protective value during exercise." 09/01/1954 - "[Functional character of the vitamins based on the study and considerations of unusual circumstances during World War II. I. Vitamin E deficiencies]." 01/01/1997 - "Treatment must be tailored to the underlying cause of vitamin E deficiency and may include oral or parenteral vitamin supplementation. "
8.	Sulfhydryl Compounds (Thiols)IBA 01/01/2021 - "Vitamin E deficiency dysregulates thiols, amino acids and related molecules during zebrafish embryogenesis." 04/01/2001 - "Vitamin E deficiency partly uncoupled the two processes: ascorbate oxidation increased, while protein thiol oxidation decreased. " 12/01/2001 - "(3) A certain degree of protection against atherogenesis and immune dysfunction may be achieved by preventing vitamin E deficiency and an excessive oxidation of the glutathione-supported thiol pool." 10/01/1968 - "Degradation of membrane phospholipids and thiols in peroxide hemolysis: studies in vitamin E deficiency." 01/01/2021 - "Vitamin E deficiency in zebrafish embryos initiates lipid peroxidation, depletes a specific phospholipid (DHA-phosphatidyl choline), causes secondary deficiencies of choline, betaine and critical thiols (such as glutathione), and dysregulates energy metabolism. "
9.	Glutathione (Reduced Glutathione)IBA 03/01/1989 - "Therefore, in the perfused rat liver model, no evidence was obtained that vitamin E deficiency activates the hepatic glutathione system." 11/01/1958 - "Effects of vitamin E deficiency on tissue and erythrocyte glutathione." 08/15/1998 - "Regenerative response in acute renal failure due to vitamin E deficiency and glutathione depletion in rats." 02/01/1991 - "These results suggest that the kidney injuries in rats may be caused by lipid peroxidation induced by vitamin E deficiency and glutathione depletion." 02/01/2004 - "Comparison of other features in these samples suggested vitamin E deficiency; did not have a significant impact upon mtDNA translation; induced a compensatory increase in glutathione levels in muscle, which was less marked in the liver, but probably most interestingly caused a significant decrease in the mitochondrial membrane fluidity in muscle but not in liver mitochondria. "
10.	Vasoconstrictor AgentsIBA 12/01/1995 - "In the isolated mesenteric arterial bed electrical field stimulation (EFS) of perivascular nerves (4-32 Hz, 90 V, 1 ms, for 30 s) elicited frequency-dependent vasoconstrictor responses which were unaffected by vitamin E deficiency except at 12 months, at which age responses were significantly greater than those of the controls at 24 and 32 Hz (P < 0.01). " 01/01/1996 - "3. At basal tone, vasoconstrictor responses to electrical field stimulation (EFS) were not attenuated by vitamin E deficiency; at high stimulation frequencies, responses were enhanced. " 12/01/1995 - "Vasoconstrictor responses to doses of adenosine 5'-triphosphate (ATP) (5-5000 nmol) were significantly impaired in vitamin E-deficiency with a high PUFA diet compared to a high PUFA diet alone (P < < 0.001). " 06/01/1994 - "3. In contrast, the endothelium-independent vasodilator or vasoconstrictor responses to sodium nitroprusside and noradrenaline, respectively were not altered either by vitamin E deficiency or supplementation. "

Therapies and Procedures

1.	Therapeutics 06/01/2021 - "Serum vitamin E deficiency among people living with HIV and undergoing antiretroviral therapy at Ho Teaching Hospital, Ghana." 01/01/2020 - "First Recognized Patient with Genetic Vitamin E Deficiency Stable after 36 Years of Controlled Supplement Therapy." 11/01/1991 - "We conclude that this noninvasive test can be useful as a screen for vitamin E deficiency in children and for ascertaining response to therapy.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/01/2010 - "With very few exceptions (eg, ataxia associated with vitamin E deficiency), there are no disease-modifying therapies. " 06/01/2004 - "Results suggest that prevention of prolonged malnutrition by early diagnosis and nutritional therapy, particularly minimizing the duration of vitamin E deficiency, is associated with better cognitive functioning in children with CF."
2.	Total Parenteral Nutrition 05/01/1977 - "Can vitamin E deficiency occur in an infant receiving total parenteral nutrition." 01/01/1988 - "Studies in patients with secondary vitamin E deficiency, caused by fat malabsorption disorders and total parenteral nutrition lacking an adequate supply of vitamin E, have elucidated a clinical disorder and histologic lesions of the nervous system and muscle that closely resemble those of experimental vitamin-E-deficient animal models. " 01/01/1998 - "The effects of vitamin E on excitoxicity in cultured neurones is considered, together with ataxia due to vitamin E deficiency (AVED) arising from abetalipoproteinaemia, cholestatic liver disease, cystic fibrosis, short bowel syndrome, total parenteral nutrition, diabetic peripheral neuropathy and familial isolated vitamin E (FIVE) deficiency. " 01/01/1982 - "Vitamin E and essential fatty acid status were examined in two groups of patients, one receiving fat-free total parenteral nutrition (TPN) with intravenous all-rac-alpha-tocopherol for vitamin E deficiency and the other receiving routine intravenous fat (Intralipid, 10%) emulsions with TPN to supply both fatty acid and vitamin E requirements. "
3.	Intravenous Administration 07/01/1975 - "The intravenous administration of alpha-tocopherol to the vitamin E-deficiency rats causes a gradual 45% increase in the ubiquinone content 4h after which remains at the same level for 8 h; the ubichromenol content 2 h latter is 1.7 times as high and then it lowers gradually up to the level in the avitaminous animals." 12/01/1974 - "Studies of serum lecithin-cholesterol acyl transferase activity in rat: effect of vitamin E deficiency, oxidized dietary fat, or intravenous administration of ozonides or hydroperoxides."
4.	Subcutaneous Infusions 01/01/1986 - "A study of vitamin E deficiency was carried over a period of about 2 years in 161 transfusion dependent thalassaemic patients aged 4 months to 18 years (including 74 splenectomized subjects) all following the same transfusion and chelation protocol (pretransfusion Hb = 11 gr/dl and daily chelation with subcutaneous infusion of desferrioxamine 12 hr a day). "
5.	Nephrectomy 07/01/2002 - "In the present study the role of vitamin E deficiency in lipid peroxidation was investigated in rats submitted to subtotal nephrectomy. "