Vitamin E Deficiency

A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)

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Networked: 788 relevant articles (23 outcomes, 70 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neurologic Manifestations (Neurological Manifestations)
2.	Cholestasis
3.	Muscular Dystrophies (Muscular Dystrophy)
4.	Friedreich Ataxia (Friedreich's Ataxia)
5.	Nervous System Diseases (Neurological Disorders)

Experts

1.	Arai, Hiroyuki: 7 articles (01/2015 - 10/2003)
2.	Traber, Maret G: 7 articles (05/2013 - 12/2004)
3.	Bertoni-Freddari, Carlo: 6 articles (06/2004 - 05/2002)
4.	Fattoretti, Patrizia: 6 articles (06/2004 - 05/2002)
5.	Tamai, Hiroshi: 4 articles (04/2012 - 06/2008)
6.	Shea, Thomas B: 4 articles (02/2006 - 01/2003)
7.	Casoli, Tiziana: 4 articles (06/2004 - 05/2002)
8.	Di Stefano, Giuseppina: 4 articles (06/2004 - 05/2002)
9.	Kono, Nozomu: 3 articles (01/2015 - 01/2012)
10.	Rino, Yasushi: 3 articles (08/2014 - 02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vitamin E Deficiency:

1.	Vitamin EFDA LinkGeneric 10/01/1989 - "It appears that parenteral vitamin E administration may be suitable for therapeutic treatment of vitamin E deficiency in the black rhinoceros." 04/01/1997 - "In addition, vitamin E supplementation (450 mg/kg diet) decreased the incidence of hepatic apoptosis, while vitamin E deficiency (0 mg/kg diet) increased the incidence of hepatic apoptosis. " 08/01/1991 - "The patient presented vitamin E deficiency and the cerebellar symptoms improved with vitamin E therapy. " 01/01/1996 - "As patients with CF are often deficient in vitamin E despite daily supplementation and normal serum levels, the authors suggest that the abnormal BAEPs demonstrated in the present study may reflect prolonged intracellular vitamin E deficiency. " 07/01/1994 - "Vitamin E deficiency may be prothrombogenic by increasing platelet arachidonate, lipid peroxidation and serum TXA2 levels while vitamin E supplementation at levels used in this study may decrease such effects."
2.	alpha-TocopherolFDA Link 11/01/1984 - "His condition improved on alpha tocopherol therapy so that it is very likely that vitamin E deficiency is responsible for his neurological deficit. " 10/01/1999 - "In the isolated vitamin E deficiencies gene mutation has been cleared for alpha-tocopherol transferprotein. " 09/01/1994 - "The mechanism for the decrease in alpha-tocopherol in conjunction with the increase in BC will require further study in order to develop strategies which will prevent vitamin E deficiency in BC-supplemented individuals." 01/01/2008 - "The most studied of these is alpha-tocopherol (alpha-TOH), because this form is retained within the body, and vitamin E deficiency is corrected with this supplement. " 10/01/1998 - "The presence of neurological signs was correlated with various parameters of vitamin E deficiency, including low serum alpha-tocopherol levels and a low tocopherol/total lipid ratio which was present in 92 per cent of subjects. "
3.	SeleniumIBA 07/01/1982 - "Comparative efficacy of five supplementation procedures to control selenium-vitamin E deficiency in swine." 09/01/1977 - "Efficacy of supplements in prevention of selenium-vitamin E deficiency in swine." 08/15/2007 - "Studies of RNA viruses (e.g., coxsackievirus B and influenzavirus) have shown that selenium or vitamin E deficiency in mice increases disease severity and results in stable genomic changes in the virus that increase virulence. " 06/01/2001 - "The diets used in this study induced selenium and vitamin E deficiencies in guinea pigs. " 05/01/1977 - "A correlative study of hepatic selenium levels and depletion rates with the onset of selenium-vitamin E deficiency disease in the chick."
4.	LipofuscinIBA 01/01/1967 - "[Studies on the quantitative distribution of lipofuscin and vitamin E deficiency-pigment in nerve cells of rats of various age groups]." 01/01/2014 - "Vitamin E deficiency can lead to formation of lipofuscin aggregates. " 01/14/1994 - "There was no statistically significant effect of vitamin E deficiency or supplementation on lipofuscin accumulation with age as compared with the control rats in all three brain regions of old rats. " 01/01/1987 - "There was no significant difference in the concentration of lipofuscin in the SON neurons after vitamin E deficiency but there was a significant increase in the adrenal cortical cells. " 10/01/1985 - "It has been widely speculated that this lipofuscin deposition is related to vitamin E deficiency. "
5.	alpha-tocopheryl polyethylene glycol succinateIBA 11/01/1987 - "A chronic oral dose of 15-25 IU/kg.day of TPGS corrected the biochemical vitamin E deficiency state over 1-19 mo (mean, 10.6 mo) of TPGS therapy. " 12/01/1987 - "We studied the effect of TPGS therapy on the neurologic function in 12 children with vitamin E deficiency (aged 9 months to 6 years) with prolonged forms of neonatal cholestasis. " 06/01/1994 - "Long-term (3 y) supplementation with orally administered TPGS (10,360 mg or 4000 IU/d) maintained normal plasma alpha-tocopherol concentrations, raised adipose tissue alpha-tocopherol concentrations, and prevented further progression of the neurological abnormalities resulting from vitamin E deficiency. " 11/01/1987 - "This study suggests that TPGS administered orally in a dose of 15-25 IU/kg.day may be a safe and effective form of vitamin E for prevention and correction of vitamin E deficiency during severe childhood cholestasis." 06/01/1993 - "TPGS (20-25 IU.kg-1.day-1) appears to be a safe and effective form of vitamin E for reversing or preventing vitamin E deficiency during chronic childhood cholestasis."
6.	AntioxidantsIBA 10/01/1980 - "Synthetic antioxidants were effective in alleviating the vitamin E deficiency symptoms in the chicks fed UFA and DLS + UFA, while only slightly effective in those given DLS. " 05/15/2001 - "It is unclear if temporary vitamin E deficiency exhibits deleterious consequences or can be compensated for by other cellular antioxidants. " 01/01/1983 - "Effect of antioxidants on the proliferative response of canine lymphocytes in serum from dogs with vitamin E deficiency." 11/01/1959 - "EFFECT of antioxidants on vitamin E deficiency in chicks." 02/10/1959 - "The effect of antioxidants on vitamin E deficiency symptoms and production of liver peroxide in the chicken."
7.	TocopherolsFDA Link 08/01/1985 - "We undertook to determine the efficacy of intravenous alpha-tocopheryl acetate in rapidly correcting the vitamin E deficiency of the premature infant. " 08/30/1999 - "To determine whether the role of tocopherols in adult neurogenesis may be generalized to the central nervous system, changes in adult rat dentate gyrus neurogenesis were investigated in vitamin E deficiency. " 01/01/1992 - "In vitamin E deficiency an efficient delivery of a high oral loading dose of all-rac-alpha-tocopheryl acetate to erythrocyte membranes could provide an early onset antioxidative effect. " 01/01/1956 - "[Histological aspects of the testicle of rats in vitamin E deficiency and under tocopherol acetate treatment]." 01/01/1956 - "[Histological aspects of the thyroid in rats with vitamin E deficiency and treated with tocopherol acetate]."
8.	Glutathione (Reduced Glutathione)IBA 03/01/1989 - "Therefore, in the perfused rat liver model, no evidence was obtained that vitamin E deficiency activates the hepatic glutathione system." 06/01/1988 - "In vitamin E deficiency the pro-oxidant effect of ascorbate was abolished when glutathione (GSH) was present. " 04/01/1977 - "Alcohol-induced red-cell vitamin-E deficiency with a decrease in PUFA levels may provoke an oxidation of reduced red-cell glutathione which in turn results in the enzyme instability. " 11/01/1958 - "Effects of vitamin E deficiency on tissue and erythrocyte glutathione." 12/01/2001 - "(3) A certain degree of protection against atherogenesis and immune dysfunction may be achieved by preventing vitamin E deficiency and an excessive oxidation of the glutathione-supported thiol pool."
9.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/01/1984 - "These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant. " 06/01/1982 - "These results indicated that vitamin E deficiency can slightly stimulate the formation of cyclooxygenase products derived from endogenous AA, but it did not affect the formation of lipoxygenase product in rat platelets." 01/01/1980 - "Vitamin E deficiency caused a significant reduction in cyclooxygenase activity but did not change the PGE2/PGF2 alpha ratio. "
10.	Dinoprostone (PGE2)FDA Link 06/01/1985 - "Young rats were most susceptible to PGE2 alteration by vitamin E deficiency while old rats responded most markedly to supplementation. " 01/01/1980 - "Vitamin E deficiency caused a significant reduction in cyclooxygenase activity but did not change the PGE2/PGF2 alpha ratio. "

Therapies and Procedures

1.	Total Parenteral Nutrition 05/01/1977 - "Can vitamin E deficiency occur in an infant receiving total parenteral nutrition." 01/01/1988 - "Studies in patients with secondary vitamin E deficiency, caused by fat malabsorption disorders and total parenteral nutrition lacking an adequate supply of vitamin E, have elucidated a clinical disorder and histologic lesions of the nervous system and muscle that closely resemble those of experimental vitamin-E-deficient animal models. " 01/01/1982 - "Vitamin E and essential fatty acid status were examined in two groups of patients, one receiving fat-free total parenteral nutrition (TPN) with intravenous all-rac-alpha-tocopherol for vitamin E deficiency and the other receiving routine intravenous fat (Intralipid, 10%) emulsions with TPN to supply both fatty acid and vitamin E requirements. "
2.	Subcutaneous Infusions 01/01/1986 - "A study of vitamin E deficiency was carried over a period of about 2 years in 161 transfusion dependent thalassaemic patients aged 4 months to 18 years (including 74 splenectomized subjects) all following the same transfusion and chelation protocol (pretransfusion Hb = 11 gr/dl and daily chelation with subcutaneous infusion of desferrioxamine 12 hr a day). "
3.	Nephrectomy 07/01/2002 - "In the present study the role of vitamin E deficiency in lipid peroxidation was investigated in rats submitted to subtotal nephrectomy. "
4.	Gastrectomy 12/15/2009 - "Gastrectomy should be considered a risk for vitamin E deficiency and neurological disturbance over the long-term clinical course. " 12/15/2009 - "Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy." 08/01/2014 - "Vitamin E deficiency probably begins within 6 months after gastrectomy for gastric cancer." 08/01/2014 - "Vitamin E deficiency begins within 6 months after gastrectomy for gastric cancer." 08/10/1990 - "[A case of vitamin E deficiency polyneuropathy after gastrectomy]."
5.	Intramuscular Injections 12/01/1987 - "Treatment of the vitamin E deficiency neurologic syndrome in children with chronic cholestasis is hampered by the very poor intestinal absorption of available forms of vitamin E, thus requiring prolonged treatment with intramuscular injections of vitamin E in many patients. " 10/01/1977 - "Effects of intramuscular injections of selenium and vitamin E on lesions in pigs with selenium-vitamin E deficiency syndrome were determined in 2 factorial experiments, using a total 69 pigs. " 10/01/1977 - "Effects of intramuscular injections of selenium and vitamin E on selenium-vitamin E deficiency in young pigs."