Vitamin D

A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.

Networked: 15705 relevant articles (792 outcomes, 2784 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Grant, William B: 124 articles (12/2015 - 01/2002)
2.	Holick, Michael F: 100 articles (08/2015 - 01/2003)
3.	Hollis, Bruce W: 67 articles (04/2015 - 07/2002)
4.	Giovannucci, Edward: 63 articles (09/2015 - 03/2005)
5.	Camargo, Carlos A: 62 articles (12/2015 - 04/2005)
6.	Tangpricha, Vin: 54 articles (12/2015 - 06/2003)
7.	Hewison, Martin: 47 articles (04/2015 - 03/2003)
8.	Reichrath, Jörg: 45 articles (10/2014 - 01/2002)
9.	Souberbielle, Jean-Claude: 40 articles (01/2016 - 08/2003)
10.	Chen, Tai C: 40 articles (12/2015 - 01/2003)

Related Diseases

1.	Vitamin D Deficiency 07/01/2013 - "As vitamin D deficiency is highly prevalent among stone formers, future prospective studies are needed to establish the biological effect, as well as the safety and efficacy of nutritional vitamin D therapy in this unique patient population." 01/01/2013 - "This strategy is a highly efficacious way for improving the vitamin D status for children and adults and preventing vitamin D deficiency. " 09/01/1994 - "Oral doses of 2.5 mg given every 3 mo appear to provide the best protection against vitamin D deficiency and vitamin D overload in high-risk infant populations that are unsuitable for daily vitamin D supplementation." 12/01/2014 - "Even though important factors for vitamin D synthesis were similar, there was severe vitamin D deficiency in patients presenting with an acute episode, significantly different from those in remission. " 05/01/2014 - "This study explored the efficacy of an alternative way of vitamin D supplementation in an area with a high prevalence of vitamin D deficiency in mothers. "
2.	Osteoporosis 02/01/2016 - "Vitamin D is reported to be beneficial on endothelial function, but it remains controversial whether vitamin D is effective for endothelial dysfunction under the treatment for osteoporosis in postmenopausal women. " 01/01/2011 - "Vitamin D supplementation for 12 months of osteoporosis and low bone mass therapy in children caused a statistically significant increase in concentrations of the hepatic metabolite of vitamin D and a significant reduction in serum PTH levels. " 06/01/2005 - "More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population." 01/01/1997 - "Although vitamin D supplementation decreases bone loss and fracture risk in the frail elderly, vitamin D metabolites may prove more useful in the treatment of elderly women with vertebral osteoporosis." 04/01/2005 - "Recently, vitamin D metabolites have been internationally recognized to be effective for osteoporosis. "
3.	Neoplasms (Cancer) 07/01/2006 - "Cancer Therapy: Knowledge of the underlying molecular mechanisms that mediate the antitumor effects of vitamin D analogs has expanded greatly during recent years and results from the first clinical trials indicate that such analogs hold promise for cancer therapy, most probably in combination with other agents. " 08/01/2013 - "Moreover, vitamin D has been proven to have many health benefits such as prevention of cancer, improved cardiovascular health among many others. " 01/01/2013 - "Therapeutic use of vitamin D compounds has proven beneficial in several cancer types, but more recently these compounds have been shown to prevent UV-induced cell death and DNA damage in human skin cells. " 01/01/2009 - "Although presenting and evaluating evidence for the beneficial role of UVB and vitamin D in reducing the risk of cancer, it discounted or omitted important evidence in support of the efficacy of vitamin D. " 01/15/2008 - "These data, together with those for internal cancers and the beneficial effects of an optimal vitamin D status, indicate that increased sun exposure may lead to improved cancer prognosis and, possibly, give more positive than adverse health effects."
4.	Secondary Hyperparathyroidism 11/01/2015 - "Further research is needed to evaluate whether activated or nutritional vitamin D therapy are beneficial in dialysis patients for outcomes other than secondary hyperparathyroidism. " 04/01/2011 - "Vitamin D compounds have been used successfully to treat secondary hyperparathyroidism for almost three decades. " 08/01/2010 - "Early intervention with intravenous or pulse oral vitamin D therapy is more effective in the treatment of secondary hyperparathyroidism." 01/01/2007 - "Available evidence suggests that calcimimetics, phosphate binders and vitamin D or its analogues are effective in the treatment of secondary hyperparathyroidism. " 06/01/1989 - "The indication seems questionable in cases with secondary hyperparathyroidism which can now be effectively treated with 1 alpha-hydroxylated forms of vitamin D. "
5.	Rickets (Rachitis) 08/04/2011 - "Vitamin D supplementation for the prevention of rickets is one of the oldest and most effective prophylactic measures in medicine, having virtually eradicated rickets in North America. " 07/01/2004 - "Her rickets improved dramatically with vitamin D treatment. " 01/01/2014 - "Firstly, discovery that vitamin D is the cure for rickets, brought us supplementation programs and rapid irradiation of this devastating disease. " 07/01/2011 - "Successful therapy of vitamin D-dependant rickets in a kitten." 05/01/1992 - "To determine whether amounts of vitamin D lower than recommended doses are effective in preventing rickets, 256 term infants from two northern and two southern cities in China were studied in a randomized trial of vitamin D supplementation (100, 200, or 400 IU/day) during the first 6 months of life. "

Related Drugs and Biologics

1.	Calcium
2.	hydroxide ion
3.	Cholecalciferol (Vitamin D3)
4.	Calcitriol (Calcijex)
5.	Diphosphonates
6.	Hormones
7.	cinacalcet (Sensipar)
8.	1-hydroxycholecalciferol (alfacalcidol)
9.	25-hydroxyvitamin D
10.	Calcitriol Receptors (Calcitriol Receptor)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Thyroidectomy
3.	Aftercare (After-Treatment)
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Resistance Training