Vitamin A (Retinol)

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

Also Known As:

Networked: 7006 relevant articles (345 outcomes, 1074 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Tanumihardjo, Sherry A: 27 articles (11/2015 - 04/2003)
2.	Goodman, Gary E: 26 articles (11/2015 - 11/2002)
3.	Semba, Richard D: 23 articles (08/2015 - 09/2002)
4.	Barnett, Matt J: 18 articles (11/2014 - 11/2002)
5.	Thornquist, Mark D: 18 articles (11/2014 - 11/2002)
6.	Willett, Walter C: 17 articles (05/2014 - 01/2002)
7.	Neuhouser, Marian L: 16 articles (11/2015 - 04/2003)
8.	Raila, Jens: 16 articles (07/2015 - 01/2004)
9.	Schweigert, Florian J: 16 articles (07/2015 - 11/2003)
10.	Aaby, Peter: 16 articles (06/2015 - 04/2002)

Related Diseases

1.	Vitamin A Deficiency 02/01/2015 - "through food-based approaches, including fortification, and through regular low-dose supplementation-are highly effective in increasing serum retinol (SR) and reducing vitamin A deficiency; (iii) therefore a policy shift is needed, based on consideration of current evidence. " 01/01/2010 - "Beginning in the 1960s, intervention trials showed that vitamin A deficiency disorders could be prevented in developing countries with periodic vitamin A dosing, and in the 1980s and 1990s, large randomized, double-blind, placebo-controlled clinical trials demonstrated the marked efficacy of vitamin A supplementation in reducing childhood mortality." 05/01/2006 - "The proposal of the present study was to assess the efficacy of supplementation with high retinol doses in HIV-infected patients with vitamin A deficiency. " 01/01/2003 - "Consumption of RPO incorporated in a sweet snack or biscuits significantly improved plasma retinol concentrations in children with subclinical vitamin A deficiency. " 04/01/1990 - "Two models could be proposed: 1) a preferential secretion of holo-RBP with variations in RBP catabolism or synthesis in vitamin A-deficient liver and 2) a continuous secretion of RBP by the liver with a rapid clearance of plasma apo-RBP in vitamin A deficiency."
2.	Neoplasms (Cancer) 02/01/2000 - "In groups already having sufficient dietary or supplemental vitamin A, cancer prevention by added vitamin A may not be particularly effective. " 02/01/2000 - "Apparently, in populations deficient in vitamin A (caused by an inadequate diet or tobacco use), supplementation programs appear to be effective in reducing cancer incidence. " 01/01/1982 - "Vitamin A analogues, such as retinoid acid, have been shown to be effective in the treatment of various skin disorders in humans; these compounds have also caused a reduction in the incidence of carcinogen-induced tumors in experimental animals. " 05/01/1980 - "This model appears to be very useful for analyzing the mechanisms of terminal differentiation and its modulation by vitamin A in tumor cells." 07/01/1998 - "The efficacy of vitamin A in the prevention of oral cavity cancer has been studied during the last years due to the interest for a possible application of new drugs in the treatment of second primary tumours and multiple neoplasms. "
3.	Measles 01/01/1993 - "These findings, along with those from three other trials in Africa, suggest that high dose vitamin A reduces the severity of complications during measles." 10/01/2012 - "The proportion of breastfeeding practices, measles vaccination coverage and vitamin A supplementation among 12-59 months old improved from 79% to 85%, 69% to 85% and 26% to 74%, respectively, which were significant. " 04/01/2010 - "We included six high-quality RCTs in the meta-analysis of vitamin A treatment of measles which found no significant reduction in measles morality. " 12/01/2002 - "At the 2-wk follow-up visit, serum retinol and the RBP/TTR ratio were significantly greater in marginally VA-deficient measles patients receiving VA supplements than in those receiving placebo; whereas in VA-sufficient measles patients, retinol increased in those receiving VA supplements or placebo. " 03/01/1996 - "These results suggest that the evidence for the efficacy of one dose of vitamin A in oil to prevent measles complications is not as strong as that previously shown for two 200,000 IU doses of water-miscible vitamin A, and that the WHO recommendation may need to be reexamined. "
4.	Infection 10/01/1999 - "Children who experienced no respiratory infection and had vitamin A intake <400 RE/day benefited most, gaining 0.31 cm/4 months (95% CI: 0.10, 0.52) more in height compared to the placebo group. " 09/01/1994 - "There was no evidence for a major role of improved epithelial integrity and function on the biochemical indices of chronic or acute systemic infection after vitamin A supplementation. " 06/15/2007 - "We established a cohort of women for long-term follow-up to examine the association of serum retinol, carotenoid, and tocopherol concentrations with the clearance of incident cervical HPV infection. " 07/01/2015 - "Vitamin A-sufficient (A(+)) mice survived and cleared the infection by day 25. " 12/01/2010 - "We examined the hypothesis that plasma carotenoid, retinol, and tocopherol concentrations are associated with the acquisition and clearance of anal HPV infection in a cohort of 279 Hawaiian residents followed at 4-month intervals for a mean duration of 16 months. "
5.	Malnutrition 01/01/2012 - "Efficacy of high-dose vitamin A (VA) in children suffering from severe acute malnutrition (SAM) has recently been questioned. " 01/01/2012 - "Efficacy of a high-dose in addition to daily low-dose vitamin A in children suffering from severe acute malnutrition with other illnesses." 09/01/2003 - "Fortified complementary foods could be effective in preventing and controlling vitamin A and other common nutritional deficiencies in young children. " 01/01/2013 - "Review of the safety and efficacy of vitamin A supplementation in the treatment of children with severe acute malnutrition." 07/01/1999 - "We hypothesized that weekly low-dose vitamin A supplementation would prevent respiratory and diarrheal disease morbidity and that malnutrition might influence the efficacy of vitamin A supplementation. "

Related Drugs and Biologics

1.	beta Carotene (Betacarotene)
2.	Vitamin A (Retinol)
3.	Retinoids
4.	Zinc
5.	Iron
6.	Vitamins
7.	Tretinoin (Retinoic Acid)
8.	Carotenoids (Carotene)
9.	Carrier Proteins (Binding Protein)
10.	Micronutrients

Related Therapies and Procedures

1.	Chemoprevention
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Radiotherapy
5.	Fat-Restricted Diet (Diet, Fat Restricted)