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Vinblastine (Vinblastine Sulfate)

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Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Also Known As:

Vinblastine Sulfate; Velban; Vincaleukoblastine; EG Labo Brand of Vinblastine Sulfate; Faulding Brand of Vinblastine Sulfate; Gastrozepin Brand of Vinblastine Sulfate; Gry Brand of Vinblastine Sulfate; Hexal Brand of Vinblastine Sulfate; Lemblastine; Lemery Brand of Vinblastine Sulfate; Lilly Brand of Vinblastine Sulfate; Velbe; Vinblastin Hexal; Vinblastina Lilly; Vinblastinsulfat-Gry; cell pharm Brand of Vinblastine Sulfate; cellblastin; Sulfate, Vinblastine

Networked: 2763 relevant articles (221 outcomes, 491 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- Alkaloids: 1065
  - Indole Alkaloids: 36
    - Secologanin Tryptamine Alkaloids: 55
      - Vinca Alkaloids: 337
        Vinblastine: 2763
        vinorelbine: 1894
        vinflunine: 96
        VAB-IV protocol: 30
        M-VAC protocol: 28
        ABVD protocol: 11
        vindoline: 10
        vinleucinol: 8
        4-desacetylvinblastine hydrazide: 7
        FEN protocol: 5
        VAB-6 regimen: 5
        VAB-III protocol: 5
        ViFuP protocol: 5
        vintriptol: 5
        MINE regimen: 4
        vinepidine: 3
        MVP protocol 2: 2
        NIP regimen: 2
        3',4'-anhydrovinblastine: 1
        4-desacetylvinblastine: 1
        5a'-homo-vinblastine: 1
        ABV-ADV protocol: 1
        ACV protocol: 1
        AVM protocol: 1
        bis(N-ethylidene vindesine)disulfide: 1
        BVCPP protocol: 1
        caN protocol: 1
        CVPP regimen: 1
        EVAP regimen: 1
        FMN regimen: 1
        KAR 2: 1
        M-VEC protocol: 1
        MEC protocol 1: 1
        MVC regimen: 1
        NAPAVIN: 1
        PVB protocol: 1
        PVC protocol: 1
        Stanford V protocol: 1
        TVTG protocol: 1
        11'-iodovinorelbine
        12'-iodovinblastine
        16-demethoxyvindoline
        16-O-acetylvindoline
        16a'-homo-vinblastine
        17-(((4-methyl-2-oxo-2H-benzopyran-7-yl)amino)-1,4-dioxobutyl)vinblastine
        4'-deoxyvinblastine
        4-desacetylvinblastine 3-carboxyhydrazide monoclonal antibody conjugates
        4-desacetylvinblastine hydrazide-monoclonal antibody KS1-4 conjugate
        4-O-(acetyl-hydroxyprolyl-seryl-seryl-cyclohexylglycyl-glutaminyl-seryl-seryl-prolyl)-desacetylvinblastine
        4-O-deacetyl vinorelbine
        4-O-deacetylvinblastine-3-oic acid
        A-TRIPLE-V protocol
        AB-triple V protocol
        ABVDP protocol
        ABVG protocol
        AVTMF protocol
        AVV protocol
        B-CAVe protocol
        B-triple-V protocol
        BCMV protocol
        BOVAPEC protocol
        BVP protocol
        Carbo-MVE protocol
        catharanthamine
        catharinine
        CBVD protocol
        CCNU-VP protocol
        CCVPP protocol
        CGV protocol
        CHIVPP protocol
        ChlVPP protocol
        ChlVPP-EVA regimen
        CISCA(II)-VB(IV) protocol
        COPP-ABVD protocol
        CVPP I protocol
        CVPP protocol
        CVPPABO protocol
        desacetylnavelbine
        dimethylaminomethylene vinamidinium salt
        DMV protocol
        EBV protocol
        EBVD protocol
        EBVP protocol
        EMV protocol
        EV protocol 1
        EVA regimen
        EVAC-G-CSF protocol
        EVAP protocol
        FAC-MV protocol
        FAN regimen
        FUVA protocol
        FVP protocol
        GV protocol
        HM 91 protocol
        HMiVe protocol
        KAR 3
        KAR 4
        LMV protocol
        LY 256787
        LY 266070
        M-CAVI protocol
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - Indole Alkaloids: 36
      - Secologanin Tryptamine Alkaloids: 55
        Vinca Alkaloids: 337
        Vinblastine: 2763
        vinorelbine: 1894
        vinflunine: 96
        VAB-IV protocol: 30
        M-VAC protocol: 28
        ABVD protocol: 11
        vindoline: 10
        vinleucinol: 8
        4-desacetylvinblastine hydrazide: 7
        FEN protocol: 5
        VAB-6 regimen: 5
        VAB-III protocol: 5
        ViFuP protocol: 5
        vintriptol: 5
        MINE regimen: 4
        vinepidine: 3
        MVP protocol 2: 2
        NIP regimen: 2
        3',4'-anhydrovinblastine: 1
        4-desacetylvinblastine: 1
        5a'-homo-vinblastine: 1
        ABV-ADV protocol: 1
        ACV protocol: 1
        AVM protocol: 1
        bis(N-ethylidene vindesine)disulfide: 1
        BVCPP protocol: 1
        caN protocol: 1
        CVPP regimen: 1
        EVAP regimen: 1
        FMN regimen: 1
        KAR 2: 1
        M-VEC protocol: 1
        MEC protocol 1: 1
        MVC regimen: 1
        NAPAVIN: 1
        PVB protocol: 1
        PVC protocol: 1
        Stanford V protocol: 1
        TVTG protocol: 1
        11'-iodovinorelbine
        12'-iodovinblastine
        16-demethoxyvindoline
        16-O-acetylvindoline
        16a'-homo-vinblastine
        17-(((4-methyl-2-oxo-2H-benzopyran-7-yl)amino)-1,4-dioxobutyl)vinblastine
        4'-deoxyvinblastine
        4-desacetylvinblastine 3-carboxyhydrazide monoclonal antibody conjugates
        4-desacetylvinblastine hydrazide-monoclonal antibody KS1-4 conjugate
        4-O-(acetyl-hydroxyprolyl-seryl-seryl-cyclohexylglycyl-glutaminyl-seryl-seryl-prolyl)-desacetylvinblastine
        4-O-deacetyl vinorelbine
        4-O-deacetylvinblastine-3-oic acid
        A-TRIPLE-V protocol
        AB-triple V protocol
        ABVDP protocol
        ABVG protocol
        AVTMF protocol
        AVV protocol
        B-CAVe protocol
        B-triple-V protocol
        BCMV protocol
        BOVAPEC protocol
        BVP protocol
        Carbo-MVE protocol
        catharanthamine
        catharinine
        CBVD protocol
        CCNU-VP protocol
        CCVPP protocol
        CGV protocol
        CHIVPP protocol
        ChlVPP protocol
        ChlVPP-EVA regimen
        CISCA(II)-VB(IV) protocol
        COPP-ABVD protocol
        CVPP I protocol
        CVPP protocol
        CVPPABO protocol
        desacetylnavelbine
        dimethylaminomethylene vinamidinium salt
        DMV protocol
        EBV protocol
        EBVD protocol
        EBVP protocol
        EMV protocol
        EV protocol 1
        EVA regimen
        EVAC-G-CSF protocol
        EVAP protocol
        FAC-MV protocol
        FAN regimen
        FUVA protocol
        FVP protocol
        GV protocol
        HM 91 protocol
        HMiVe protocol
        KAR 3
        KAR 4
        LMV protocol
        LY 256787
        LY 266070
        M-CAVI protocol

Experts

1.	Merli, Francesco: 11 articles (08/2015 - 12/2003)
2.	Federico, Massimo: 11 articles (09/2013 - 12/2003)
3.	Engert, Andreas: 9 articles (04/2015 - 01/2002)
4.	Connors, Joseph M: 9 articles (02/2015 - 02/2003)
5.	Viviani, Simonetta: 9 articles (06/2014 - 03/2002)
6.	Gobbi, Paolo G: 9 articles (09/2013 - 12/2003)
7.	Diehl, Volker: 8 articles (04/2015 - 01/2002)
8.	Stelitano, Caterina: 8 articles (04/2012 - 12/2003)
9.	Bonfante, Valeria: 8 articles (10/2011 - 03/2002)
10.	Gianni, Alessandro M: 7 articles (06/2014 - 03/2002)

Related Diseases

1.	Hodgkin Disease (Hodgkin's Disease) 06/01/2011 - "Here he carried out his best known clinical study-the use of vinblastine sulphate in patients with Hodgkin lymphoma. " 05/01/1979 - "randomized study of irradiation and vinblastine in clinical stages I and II of Hodgkin's disease." 06/01/1972 - "A randomized study of irradiation and vinblastine in stages I and II of Hodgkin's disease. " 04/01/2014 - "Severe neurotoxicity due to Vinblastine in Hodgkin lymphoma." 09/24/2010 - "In order to analyze the clinical relevance of the pharmacokinetic interactions between vinblastine and antiretrovirals described in literature, we evaluated all HIV-infected patients with Hodgkin's lymphoma treated with vinblastine-containing regimens and combination antiretroviral therapy, in a single clinical center. "
2.	Neoplasms (Cancer) 11/01/2008 - "The optimal dosage and clinical efficacy of vinblastine (VBL) for treatment of mast cell tumors (MCTs) in dogs has not been established. " 10/01/2006 - "This new drug family appears to be less potent than vinblastine in vitro systems, but it shows high antitumor efficacy with considerably higher doses being well tolerated in the animal tumor models. " 01/01/2015 - "In both monotypic and heterotypic models the concurrent treatment of vinblastine and radiation proved more effective inhibitors of mammary cancer cell growth. " 03/01/2007 - "In this study, we examined if the combination of Cx32-dependent tumor-suppressive effect and vinblastine (VBL), a chemotherapeutic agent which has been utilized for clinical RCC treatment, could be effective in enhancing the sensitivity of RCC to VBL treatment. " 11/01/2008 - "Efficacy of vinblastine for treatment of canine mast cell tumors."
3.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 06/04/1987 - "In a randomized clinical trial in 261 men with disseminated germ-cell tumors, we substituted etoposide for the vinblastine in this regimen in half the patients to compare the efficacy and toxicity of the two treatments. " 01/01/1982 - "Multivariate analysis of risk factors in patients with metastatic testicular germ cell tumors treated with vinblastine and bleomycin." 10/01/1980 - "CDDP combined with vinblastine and bleomycin resulted in a 39% complete response rate in testicular germ cell tumors. " 06/01/1986 - "We found combination chemotherapy with cisplatinum, vinblastine, and bleomycin (PVB therapy) effective in the treatment of a patient with a pineal germ cell tumor with peritoneal dissemination. " 05/15/1980 - "Nineteen patients considered to have metastatic primary extragonadal germ cell cancer were entered on a Phase II chemotherapy study using as induction therapy a combination of vinblastine (VLB) 12 mg/m2 day 1, bleomycin (BLEO) 15 U/m2 I.V. or I.M. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 04/01/2005 - "Phase II study of radiochemotherapy with vinblastine in invasive bladder cancer." 01/01/2015 - "To differentiate and delineate the molecular events, we developed drug resistant human transitional bladder cancer T24 cells (DRC) by treating cells with the increasing concentration of vinblastine. " 01/01/2015 - "Molecular events are associated with resistance to vinblastine in bladder cancer." 12/15/1992 - "Concurrent vinblastine and radiation therapy in bladder cancer." 04/01/1985 - "Vinblastine and methotrexate for advanced bladder cancer."
5.	Breast Neoplasms (Breast Cancer) 11/01/1987 - "We assessed the therapeutic efficacy and toxicity of continuous hepatic infusion of vinblastine in the treatment of breast cancer predominantly metastatic to the liver. " 01/01/1988 - "Phase II study of divided-dose vinblastine in advanced breast cancer patients." 01/01/2015 - "Drug treatment of these heterotypic 3D cultures confirmed treatment with radiation plus vinblastine to be additive in causing breast cancer growth inhibition. " 11/01/1996 - "Vinblastine is commonly used in metastatic breast cancer after anthracycline failure. " 01/01/1996 - "Adult patients with histologically confirmed, refractory, advanced breast cancer were treated with vinblastine at a dose of 1.7 mg/m2 per day by continuous infusion for five consecutive days. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Cisplatin (Platino)
3.	Bleomycin (Blenoxane)
4.	Methotrexate (Mexate)
5.	Dacarbazine (DIC)
6.	Vincristine (Oncovin)
7.	Etoposide (VP 16)
8.	Prednisone (Sone)
9.	Cyclophosphamide (Cytoxan)
10.	Procarbazine (Matulane)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Radiotherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Cystectomy