Vimentin

An intermediate filament protein found in most differentiating cells, in cells grown in tissue culture, and in certain fully differentiated cells. Its insolubility suggests that it serves a structural function in the cytoplasm. MW 52,000.

Networked: 5975 relevant articles (63 outcomes, 533 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Terada, Tadashi: 46 articles (02/2015 - 01/2008)
2.	Michal, Michal: 20 articles (07/2015 - 03/2002)
3.	Pekny, Milos: 17 articles (06/2015 - 05/2004)
4.	Fukunaga, Masaharu: 15 articles (10/2015 - 03/2003)
5.	Zhang, Wei: 14 articles (01/2016 - 04/2006)
6.	Wilhelmsson, Ulrika: 14 articles (12/2014 - 05/2004)
7.	Wang, Jian: 11 articles (08/2015 - 08/2004)
8.	Rekhi, Bharat: 11 articles (11/2013 - 01/2007)
9.	Hes, Ondrej: 10 articles (07/2015 - 01/2004)
10.	Liu, Yang: 9 articles (01/2015 - 07/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1992 - "Since ENU is most effective in producing tumors when administered at the 16-17th day of fetal life, vimentin-positive radial glia is a candidate target of ENU. " 01/01/2007 - "A more recent version including an epigenetic marker for the vimentin gene has further improved sensitivity for cancer, but performance relative to GFOBT or FIT is not clear. " 06/01/1990 - "It indicated that vimentin antibody is effective for tumor differential diagnosis in surgical pathology." 10/01/2014 - "Immunocytochemical staining demonstrated positive results for vimentin, CD31, and CD34 and negative staining for epithelial markers, thus supporting the diagnosis of a mesenchymal tumor of vascular origin. " 12/01/2008 - "Immunohistochemical staining showed tumor cells with positive results for vimentin and CD68. "
2.	Carcinoma (Carcinomatosis) 09/28/2014 - "Negative methylation status of vimentin predicts improved prognosis in pancreatic carcinoma." 03/01/2007 - "Ovarian clear-cell carcinoma showed weakly positive results in EMA staining and negative results in ER, PR, 34betaE12, and vimentin staining. " 01/01/1990 - "Thus, vimentin expression may be helpful in identifying a substantial subset of ER-independent breast carcinomas with poor prognostic indicators." 05/01/2011 - "The aim of the present study was to characterize immunohistochemically the expression of vimentin by canine prostatic carcinomas. " 02/01/2011 - "Oral carcinoma tissues were subjected to immunohistochemical analysis to study the implications that vimentin expression has on patient survival. "
3.	Adenocarcinoma 04/12/2011 - "The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas. " 01/01/2010 - "The aim of the present study was to evaluate the immunoreactivity of vimentin and MT in the salivary gland adenocarcinoma and its stroma in order to observe the phenomenon of stromal remodeling. " 03/15/1998 - "The interactions of tau with vimentin filaments, and its relationships with other filaments of the cytoskeletal network, were analyzed in SW-13 adenocarcinoma cells, through an integrated approach that included biochemical and immunological studies. " 12/01/1996 - "This study was designed to clarify the significance of vimentin expression in solid type poorly differentiated adenocarcinomas of the stomach. " 06/01/1992 - "This study also demonstrated consistent negative expression of vimentin in invasive cervical adenocarcinoma. "
4.	Neoplasm Metastasis (Metastasis) 10/01/1996 - "On the other hand, vimentin expression was correlated with axillary metastases and histologic grade, but not with recurrence, disease-free or overall survival. " 01/01/2014 - "Post-translational modification of podoplanin and cleavage of vimentin by DSF-Cu underscore a metastasis inhibitory property of this agent and together with our in vivo studies underscore its potential as an anti-MPM agent. " 12/01/2010 - "Recent studies have shown that vimentin was closely linked with tumorigenesis and metastasis. " 05/01/2015 - "By comparing the expression of ER, PR, HER-2, Ki67, K8, K5/6 and vimentin, we found that expression of HER-2, Ki67, K8 and vimentin is frequently lost in lymph node metastases. " 04/01/2015 - "Even within the AC-MPC entity, higher vimentin expression was correlated with more frequent vascular invasion and more advanced node metastasis (P < 0.02), and multivariate analysis showed that high vimentin expression and worse node statuses were independent indicators of adverse prognosis (P < 0.048). "
5.	Melanoma (Melanoma, Malignant) 01/01/2014 - "Immunohistochemical study (positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin) confirmed metastatic malignant melanoma. " 08/01/2015 - "Malignant melanomas are known to express vimentin, among other intermediate filaments. " 05/05/2015 - "Review of the excision and immunohistochemical analysis revealed the malignant plasmacytoid cells stained with vimentin, S-100, HMB-45, and other staining patterns consistent with melanoma. " 12/01/2014 - "Review of the biopsy and immunohistochemical analysis revealed the malignant signet-ring cells stained with S100, vimentin, and melanoma cocktail, in keeping with melanoma. " 04/01/2014 - "Effect of downregulation of ZEB1 on vimentin expression, tumour migration and tumourigenicity of melanoma B16F10 cells and CSCs."

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5.	S100 Proteins (S 100 Protein)
6.	Carcinoembryonic Antigen
7.	Carbon Monoxide
8.	Rheumatoid Factor
9.	cyclic citrullinated peptide
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Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplantation (Transplant Recipients)
4.	Adjuvant Chemotherapy
5.	Vitreoretinal Surgery