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Ventricular Outflow Obstruction

Subscribe to New Research on Ventricular Outflow Obstruction

Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS.

Also Known As:

Left Ventricular Outflow Obstruction; Outflow Obstruction, Left Ventricular; Outflow Obstruction, Right Ventricular; Right Ventricular Outflow Obstruction; Obstruction, Ventricular Outflow; Obstructions, Ventricular Outflow; Outflow Obstruction, Ventricular; Outflow Obstructions, Ventricular; Ventricular Outflow Obstructions; Ventricular Outflow Obstruction, Left; Ventricular Outflow Obstruction, Right

Networked: 94 relevant articles (3 outcomes, 6 trials/studies)

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Disease Context: Research Results

Cardiovascular Diseases: 37259
- Heart Diseases: 18762
  - Ventricular Outflow Obstruction: 94
    - Aortic Valve Stenosis: 2889
    - Pulmonary Valve Stenosis: 869

Related Diseases

1.	Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
2.	Cardiogenic Shock
3.	Heart Diseases (Heart Disease)
4.	Aortic Valve Stenosis (Aortic Stenosis)
5.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)

Experts

1.	Sakamoto, Takahiko: 2 articles (08/2011 - 03/2002)
2.	Siniorakis, Eftychios: 1 article (01/2016)
3.	Arvanitakis, Spyridon: 1 article (01/2016)
4.	Rentoukas, Elias: 1 article (01/2016)
5.	Arvanitakis, S: 1 article (10/2015)
6.	Zampelis, C: 1 article (10/2015)
7.	Siniorakis, E: 1 article (10/2015)
8.	Panta, S: 1 article (10/2015)
9.	Rentoukas, E: 1 article (10/2015)
10.	Aivalioti, F: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ventricular Outflow Obstruction:

1.	ThalliumIBA 03/01/1992 - "After surgical relief of left ventricular outflow obstruction (basal gradient reduced from 62 +/- 40 to 7 +/- 12 mm Hg, p less than 0.001; peak provokable gradient reduced from 131 +/- 27 to 49 +/- 36 mm Hg, p less than 0.001), repeat exercise thallium studies showed complete normalization of perfusion defects in 11 patients, including the two patients with fixed defects alone before surgery, and improvement in the magnitude and distribution of perfusion defects in five additional patients. "
2.	Disopyramide (Norpace)FDA LinkGeneric 11/01/1998 - "The sRVOT increased (p<0.05) from 2.1-4.8 (2.7 +/- 1.5)mm to 3.0-8.1 (4.9 +/- 2.4)mm, while RVOT peak velocity decreased (p<0.05) from 2.20-4.88 (3.70 +/- 0.97)m/sec to 2.05-4.07 (2.92 +/- 0.72)m/sec. Disopyramide alleviates hypoxia in patients of TF through its negative inotropic action on right ventricular outflow obstruction." 01/01/1984 - "[Beneficial effects of disopyramide on left ventricular outflow obstruction in a case of hypertrophic obstructive cardiomyopathy]." 03/01/2000 - "Continuous intravenous drip infusion of disopyramide is effective for the treatment of cardiogenic shock due to severe left ventricular outflow obstruction in patients with hypertrophic obstructive cardiomyopathy."
3.	Calcium Channels (Calcium Channel)IBA 04/01/2001 - "After having stopped treatment with nitrates, digoxin, and diuretics, drug therapy with calcium channel antagonists or beta-blockers was started, and rapid clinical improvement with disappearance of left ventricular outflow obstruction was observed. "
4.	NitratesIBA 04/01/2001 - "After having stopped treatment with nitrates, digoxin, and diuretics, drug therapy with calcium channel antagonists or beta-blockers was started, and rapid clinical improvement with disappearance of left ventricular outflow obstruction was observed. "
5.	DiureticsIBA 04/01/2001 - "After having stopped treatment with nitrates, digoxin, and diuretics, drug therapy with calcium channel antagonists or beta-blockers was started, and rapid clinical improvement with disappearance of left ventricular outflow obstruction was observed. "
6.	Digoxin (Digitek)FDA LinkGeneric 04/01/2001 - "After having stopped treatment with nitrates, digoxin, and diuretics, drug therapy with calcium channel antagonists or beta-blockers was started, and rapid clinical improvement with disappearance of left ventricular outflow obstruction was observed. "
7.	Dichlorodiphenyldichloroethane (DDD)IBA 06/01/1992 - "The present study examines prospectively the ability of dual-chamber (DDD) pacing to improve symptoms and relieve left ventricular outflow obstruction in such patients. " 01/01/1994 - "Indications for AVN ablation were drug refractory atrial fibrillation in 24 patients, and rapid AVN conduction preventing septal pre-excitation by DDD pacemaker, inserted for relief of left ventricular outflow obstruction, in three cases. " 08/01/1998 - "A case of hypertrophic obstructive cardiomyopathy with localized upper septal hypertrophy: reduction of left ventricular outflow obstruction by dual-chamber (DDD) pacing."
8.	OxygenIBA 04/01/1989 - "To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-myectomy; six, mitral valve replacement; one, both myotomy-myectomy and mitral valve replacement) who underwent both preoperative and postoperative studies. " 10/01/1991 - "In order to investigate the relation between exercise intolerance and cardiac output (CO) increase during exercise in patients with hypertrophic cardiomyopathy (HCM), submaximal treadmill exercise (Sheffield protocol) with simultaneous measurement of CO and oxygen uptake (VO2) by acetylene rebreathing method were performed in twelve patients with HCM who had no demonstrable left ventricular outflow obstruction and fifteen control men. "
9.	Lactic Acid FDA LinkGeneric 04/01/1989 - "To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-myectomy; six, mitral valve replacement; one, both myotomy-myectomy and mitral valve replacement) who underwent both preoperative and postoperative studies. "
10.	pro-brain natriuretic peptide (1-76)IBA 12/01/2004 - "In the present study, we prospectively assessed in hypertrophic cardiomyopathy the relationship of plasma NT-proBNP levels with the extent of left ventricular hypertrophy, presence of left ventricular outflow obstruction and echocardiographic parameters of left ventricular diastolic function. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/2015 - "There are a number of treatment modalities for these patients, including pharmacotherapy to control symptoms, implantable cardiac defibrillators to manage malignant arrhythmias, and surgical myectomy and septal ablation to decrease the left ventricular outflow obstruction. " 04/01/2001 - "After having stopped treatment with nitrates, digoxin, and diuretics, drug therapy with calcium channel antagonists or beta-blockers was started, and rapid clinical improvement with disappearance of left ventricular outflow obstruction was observed. "
2.	Intravenous Infusions 03/01/2000 - "Continuous intravenous drip infusion of disopyramide is effective for the treatment of cardiogenic shock due to severe left ventricular outflow obstruction in patients with hypertrophic obstructive cardiomyopathy."
3.	Stents 06/01/2009 - "Stepwise expansion of the self-expanding stent valve with annular fixation (balloon-expandable stent valve) resulted in systolic ventricular increase from 120 to 121 mmHg (126 to 830+/-76 mmHg), and left ventricular outflow obstruction with mean transvalvular gradient of 11+/-1.5 mmHg (366+/-202 mmHg), systolic aortic pressure dropped distal to the valve from 121 to 64.5+/-2 mmHg (123 to 55+/-30 mmHg) N.S., and output collapsed to 1.9+/-0.06 l/min (0.71+/-0.37 l/min* (before complete obstruction)). " 12/01/2000 - "These characteristics make the Palmaz Corinthian stent a reasonable alternative for use in a select group of infants and small children who are not candidates for surgical repair of postoperative right ventricular outflow obstruction." 12/01/2000 - "New Palmaz Corinthian stents were placed through 6 French sheaths in four high-risk patients with postoperative right ventricular outflow obstruction. " 12/01/2000 - "Initial experience using the Palmaz Corinthian stent for right ventricular outflow obstruction in infants and small children." 01/01/1994 - "Intravascular stents for management of pulmonary artery and right ventricular outflow obstruction."
4.	Norwood Procedures 07/01/1998 - "The purpose of this study was to identify echocardiographic hemodynamic and morphometric factors that would predict which infants with critical aortic stenosis could undergo relief of left ventricular outflow obstruction as opposed to the Norwood procedure. "
5.	Prostheses and Implants (Prosthesis) 03/01/2010 - "High gradients after aortic valve replacement can be, but are not necessarily, caused by left ventricular outflow obstruction; and not all left ventricular outflow obstruction after aortic valve replacement is due to prosthesis dysfunction. " 07/01/2000 - "High velocities are transient in some patients, although persistence of high transvalvular velocity suggests 'prosthesis-patient mismatch' with incomplete relief of left ventricular outflow obstruction." 08/01/1991 - "Left ventricular outflow obstruction resulting from insertion of mitral prostheses leaving the native leaflets intact: adverse clinical outcome in seven patients." 07/01/1990 - "These exercise Doppler echocardiography data suggest that mechanical moncuspid aortic prosthesis 19, 21 and same 23, result in left ventricular outflow obstruction mainly during exercise; these facts should be taken into account when aortic prosthesis insertion is considered. " 05/01/1989 - "Left ventricular outflow obstruction by a mitral valve prosthesis: Doppler ultrasound and cardiac catheterization findings."