Nasal Decongestants (Decongestants)

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)

Also Known As:

Networked: 277 relevant articles (29 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Flynn, C A: 4 articles (01/2007 - 01/2001)
2.	Wald, Ellen R: 3 articles (01/2014 - 01/2010)
3.	Shaikh, Nader: 3 articles (01/2014 - 01/2010)
4.	Meltzer, Eli O: 3 articles (01/2010 - 01/2003)
5.	Hey, J A: 3 articles (01/2008 - 03/2001)
6.	McLeod, R L: 3 articles (01/2008 - 03/2001)
7.	Mingo, G G: 3 articles (01/2008 - 03/2001)
8.	Taverner, D: 3 articles (01/2007 - 01/2000)
9.	Griffin, G H: 3 articles (01/2007 - 01/2004)
10.	Schultz, J K: 3 articles (01/2007 - 01/2004)

Related Diseases

1.	Sinusitis 05/01/1996 - "The results of this study suggest that the administration of decongestants may cause ciliary loss with subsequent sinusitis." 03/01/2011 - "Compared with AR subjects with no SHS exposure, subjects with AR and SHS were more likely to report a family history of chronic sinusitis (p = 0.04) and use nasal decongestants (p = 0.012). " 10/01/2002 - "The initial management of acute sinusitis should be directed toward the relief of symptoms with a 7-day course of decongestants and mucoevacuents. " 08/01/1996 - "Proper therapy, with antimicrobial and decongestants combined when indicated with surgical drainage and correction of pathology, constitutes the cornerstone of management of sinusitis." 07/01/1996 - "The treatment of sinusitis is based on the removal of all nasal tubes, topical decongestants, and maxillary sinus drainage and lavage. "
2.	Common Cold 01/01/2009 - "To assess the efficacy of nasal decongestants at reducing the symptom of nasal congestion in adults and children with the common cold and to identify possible adverse effects associated with their use. " 01/01/2007 - "To assess the efficacy of nasal decongestants at reducing the symptom of nasal congestion in adults and children with the common cold and to identify possible adverse effects associated with their use. " 01/01/2004 - "To assess the efficacy of nasal decongestants at reducing the symptom of nasal congestion in adults and children with the common cold and to identify possible adverse effects associated with their use. " 01/01/2000 - "To assess the efficacy of nasal decongestants at reducing the symptom of nasal congestion in adults and children with the common cold and to identify possible adverse effects associated with their use. " 01/01/2009 - "Randomised, placebo controlled trials of single-active oral and topical nasal decongestants in adults and children suffering from common cold. "
3.	Rhinitis 01/01/2003 - "Nasal decongestants give good temporary relief from pregnancy rhinitis, but they tend to be overused, leading to the development of rhinitis medicamentosa. " 09/01/2005 - "The aim of this study was to establish the nasal mucosal cytology of patients with rhinitis medicamentosa and evaluation of usefulness of exfoliative cytology in diagnostics of underlying reason of nasal decongestants overuse. " 07/01/2003 - "These results suggest that the canine model may be used to study upper-airway diseases such as allergic rhinitis and to evaluate the pharmacologic activity of nasal decongestants." 05/01/2014 - "Half of the individuals self-medicating persistent rhinitis overused intranasal decongestants, despite the fact that they were educated about the limit on duration of use." 06/01/2013 - "The review of the literature conducted by the task force studied in detail the concepts of "rebound congestion" and "rhinitis medicamentosa" often reported in a context of misuse, particularly of topical nasal decongestants. "
4.	Cough 06/01/1999 - "Significantly fewer patients than controls used cough and cold products (9% vs. 17%; p < 0.05), specifically oral decongestants (0.6% vs. 5%; p < 0.01), and more patients than controls used nutritional supplements (17% vs. 4%; p < 0.01). " 07/01/1995 - "[Cough induced by nasal vasoconstrictors]." 10/01/1995 - "For respiratory drugs, costs were significantly higher for inhaled adrenoceptor stimulants, steroid inhalers, large spacers, and peak flow meters, but lower for cough medicines and systemic nasal decongestants: the number of items prescribed showed similar patterns. " 12/01/1999 - "Overall, there are few data from human studies on the use of antihistamines, decongestants, and cough products during breastfeeding. " 10/01/1991 - "Prescribing of decongestants, especially systemic, decreased during the study period whereas that of anti-asthmatics increased, partly due to the non-approved use of these drugs for common cough. "
5.	Pain (Aches) 01/01/2004 - "Finally, other than pain medication, there is little evidence that use of adjunctive treatments, such as decongestants, is effective in symptom relief. " 01/01/1998 - "The questionnaires inquired about nasal allergy, nasal congestion, previous and actual ear pain, use of decongestants and experience of inflating the Otovent set during descent. " 10/01/2014 - "So-called 'sinus pain' is a common complaint in GP and ear, nose and throat clinics, and patients often receive treatment with antibiotics and decongestants. " 05/01/2011 - "Symptomatic treatment with analgesics, decongestants, and saline nasal irrigation is appropriate in patients who present with nonsevere symptoms (e.g., mild pain, temperature less than 101°F [38.3°C]). " 10/01/1999 - "Those in the control population reporting symptoms were treated with pain relievers and decongestants, whereas those in the test population reporting symptoms were treated with hourly doses of 1000 mg of Vitamin C for the first 6 hours and then 3 times daily thereafter. "

Related Drugs and Biologics

1.	Histamine Antagonists (Antihistamines)
2.	Steroids
3.	Anti-Bacterial Agents (Antibiotics)
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	Oxymetazoline
6.	Expectorants (Mucolytics)
7.	Pseudoephedrine
8.	Antitussive Agents (Antitussives)
9.	Dextromethorphan (Levomethorphan)
10.	Codeine (Codeine Phosphate)

Related Therapies and Procedures

1.	Immunotherapy
2.	Hyperbaric Oxygenation
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Self Medication