Vascular Headaches (Vascular Headache)

Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.

Also Known As:

Networked: 150 relevant articles (9 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Migraine Disorders (Migraine)
2.	Pain (Aches)
3.	Shock
4.	Headache (Headaches)
5.	Brain Ischemia (Cerebral Ischemia)

Experts

1.	Strecker, T: 2 articles (06/2003 - 04/2002)
2.	Messlinger, K: 2 articles (06/2003 - 04/2002)
3.	Sarma, Ganti S: 1 article (04/2015)
4.	Goyal, Amit Kumar: 1 article (04/2015)
5.	Garg, Tarun: 1 article (04/2015)
6.	Rath, Goutam: 1 article (04/2015)
7.	Kumar, Animesh: 1 article (04/2015)
8.	Papaioannou, George: 1 article (08/2013)
9.	Lazopoulos, George: 1 article (08/2013)
10.	Kantartzis, Michael: 1 article (08/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Headaches:

1.	Pizotyline (BC 105)IBA 01/01/1972 - "Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches." 11/01/1969 - "[Tests of BC 105 in 20 cases of vascular headache]." 01/01/1974 - "A cooperative study on the clinical aspects of migraine and vascular headache and their response to sandomigran." 10/01/1977 - "These properties, and the well-documented effect of pizotifen in migraine, could make it an alternative in treating patients suffering from the often seen combination of vascular headache/depression."
2.	Ergot AlkaloidsIBA 01/01/1990 - "Since the ergot alkaloids possess a similar profile of drug activity, it is suggested that drugs useful in the treatment of acute vascular headaches may share a similar mechanism of action." 12/01/1988 - "Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches." 08/01/1992 - "Moskowitz argues that blockade of neural transmission and the neurogenic inflammatory response provides a mechanism by which sumatriptan and ergot alkaloids alleviate vascular headaches. "
3.	OxygenIBA 04/01/1995 - "It has been theorized that the efficacy of raising blood oxygen levels in vascular headache is mediated by vasoconstriction and metabolic effects. " 01/01/1997 - "Vascular headaches can mimic DCS by responding to oxygen."
4.	Methylergonovine (Methergine)FDA LinkGeneric 07/01/1997 - "Methylergonovine maleate (Methergine), an ergot derivative with vasoconstrictive properties, has been cited as an effective treatment for vascular headaches. "
5.	gamma-Aminobutyric Acid (GABA)IBA 09/01/2008 - "These results provide experimental basis for explanation of the clinical efficacy of the GABA-positive drugs in vascular headaches."
6.	Ergotamine (Ergotamine Tartrate)FDA LinkGeneric 02/01/1966 - "A study of a non-ergotamine agent in the office treatment of vascular headache." 08/01/2013 - "Ergotamine is used to abort or prevent vascular headache. " 01/01/2012 - "Ergotamine is a well known pharmacological remedy applied in neurology (treatment of vascular headache) and in obstetrics (abortive remedy, uterus atony). " 06/01/2007 - "Ergotamine has been used for therapeutic purposes since the 1950s, usually to treat vascular headache. " 04/01/1963 - "Ergotamine tartrate in the treatment of vascular headaches."
7.	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/01/2003 - "The role of nitric oxide in vascular headache." 09/01/1995 - "Nitric oxide (NO) and the dura mater are implicated in the pathogenesis of vascular headache. " 01/12/1994 - "The nitric oxide molecule, a potent vasodilator, may contribute to the vascular headache process by dilating dural vasculature. " 04/01/1995 - "The nitric oxide hypothesis of migraine and other vascular headaches." 05/01/1994 - "Nitric oxide is a key molecule in migraine and other vascular headaches."
8.	Histamine (Histamine Dihydrochloride)FDA Link 04/01/1980 - "The i.v. histamine infusion test is a useful model for the study of experimental vascular headache." 11/01/1966 - "Intradermal histamine therapy of vascular headache." 01/01/1951 - "Chronic vascular headache treated by intense histamine therapy; therapeutic and side-effects as well as mechanism of histamine treatment." 10/01/1950 - "[Endovenous histamine in treatment of vascular headache]." 08/11/1980 - "[Skin tests, blood histamine level and eosinophilia in vascular headache]."
9.	Methysergide (Sansert)FDA Link 05/05/1967 - "[Experience with methysergide in 48 cases of vascular headache]." 10/01/1963 - "USE OF METHYSERGIDE IN THE TREATMENT OF EXTRACRANIAL VASCULAR HEADACHE." 01/01/1962 - "Prophylaxis of frequent vascular headache with methysergide." 03/01/1961 - "Evaluation of UML-491 in the treatment of vascular headaches. " 06/01/1963 - "An evaluation of methysergide in the prevention of migraine and other vascular headaches."
10.	Calcitonin Gene-Related PeptideIBA 02/01/2003 - "Calcitonin gene-related peptide (CGRP) is involved in the underlying pathophysiology of all vascular headaches, including migraines. " 11/01/2002 - "Nitric oxide (NO) and calcitonin-gene-related peptide (CGRP) are implicated in the pathophysiology of vascular headaches. " 06/01/2003 - "Nitric oxide (NO) and calcitonin gene-related peptide (CGRP), potent vasodilators in the meninges,may be involved in the pathophysiology of vascular headaches such as migraine pain. " 04/01/2002 - "This study addresses possible interactions of the vasodilators nitric oxide (NO), calcitonin gene-related peptide (CGRP) and prostaglandins, which may be implicated in the generation of vascular headaches. "

Therapies and Procedures

1.	Psychology Biofeedback (Biofeedback) 03/01/1983 - "Vascular headache patients low in absorption were significantly improved after biofeedback training. " 03/01/1983 - "Vascular headache patients high in absorption were significantly improved following relaxation training, but not after biofeedback training. " 09/01/1991 - "The clinical utility of Tellegen's Absorption Scale was examined using a sample of 32 chronic vascular headache patients drawn from a larger treatment study investigating the efficacy of thermal biofeedback with vascular headache. " 06/01/1990 - "This study investigates the use of biofeedback, relaxation and psychotherapy on five patients with severe, vascular headaches that occurred during the course of pregnancy. " 03/01/1989 - "Two studies of the potential mechanisms of action in the thermal biofeedback treatment of vascular headache."
2.	Ganglionectomy 09/01/1998 - "The authors conclude that: 1) patients who suffer from chronic occipital pain after having sustained injury obtain worthwhile benefit from microsurgical C-2 ganglionectomy; 2) patients suffering from migraine, tension, and vascular headaches involving the occipital area are most often not helped by this operation; and 3) terms such as "shock," "electric," "shooting," "jabbing," and "sharp" used to describe occipital pain predict a favorable pain outcome following a C-2 ganglionectomy."
3.	Drug Therapy (Chemotherapy) 05/01/1986 - "Long-term drug therapy is effective for most patients with vascular headaches. "
4.	Endovascular Procedures 05/01/1993 - "Headaches during intracranial endovascular procedures: a possible model of vascular headache."
5.	Carotid Endarterectomy 07/01/1984 - "The following three unusual complications of carotid endarterectomy developed in a 64-year-old woman: vascular headaches, delayed hypertension, and seizures. " 07/01/1984 - "Hypertension, vascular headaches, and seizures after carotid endarterectomy. "