Vanadates (Orthovanadate)

Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.

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Networked: 412 relevant articles (22 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hasegawa, Yu: 6 articles (03/2012 - 09/2003)
2.	Fukunaga, Kohji: 6 articles (09/2006 - 08/2002)
3.	Kordowiak, Anna M: 4 articles (12/2011 - 05/2005)
4.	Sakurai, Hiromu: 4 articles (03/2008 - 01/2004)
5.	Morioka, Motohiro: 4 articles (09/2006 - 08/2002)
6.	Kawano, Takayuki: 4 articles (09/2006 - 08/2002)
7.	Yano, Shigetoshi: 4 articles (09/2006 - 08/2002)
8.	Pierce, Grant N: 3 articles (05/2012 - 09/2004)
9.	Clark, Tod A: 3 articles (05/2012 - 09/2004)
10.	Heyliger, Clayton E: 3 articles (05/2012 - 09/2004)

Related Diseases

1.	Hyperglycemia 07/01/2006 - "The results of the present study indicate that vanadate produced marked contraction in the normal urinary bladder rings and this contraction was significantly enhanced by hyperglycemia. " 07/01/2006 - "Hyperglycemia significantly potentiated the response of bladder rings to vanadate. " 03/01/2000 - "The contribution of gluconeogenesis to hyperglycemia in non-obese diabetic (NOD) mice has been investigated using oral vanadate administration. " 11/01/1994 - "With an identical oral vanadate regimen of 0.25 mg/mL, the ability to sustain pregnancy to term was reduced by 30% and 90% for the nondiabetic and diabetic groups, respectively, and by 84% and 100% for these groups at a dose of 0.50 mg/mL. Although the blood vanadate concentrations were an order of magnitude higher in diabetic animals treated with vanadate than in nondiabetic animals under an identical vanadate treatment, oral vanadate treatments had no measurable effects in ameliorating hyperglycemia in these diabetic pregnant animals. " 10/01/1994 - "Relationship between reduction in food intake and amelioration of hyperglycemia by oral vanadate in STZ-induced diabetic rats."
2.	Neoplasms (Cancer) 12/15/1992 - "Vanadyl ion (+4 oxidation state) has been shown to be an effective agent for chemoprotection of cancers in animals. " 01/01/2012 - "Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells." 12/01/2004 - "Vanadate, an environmental toxic metal, is considered as a potent inducer of tumors in animals and is reported to activate HIF-1 activity. " 10/01/2002 - "The results obtained also point to vanadate as a possible chemotherapic in the use of multidrug-resistant tumors." 08/30/2002 - "Vanadate is widely used in industry, and is a potent inducer of tumors in humans and animals. "
3.	Cataract (Cataracts) 05/01/1993 - "Cataract development was entirely suppressed in vanadyl-treated compared to untreated, diabetic rats. " 02/01/1994 - "In diabetic animals, vanadyl treatment significantly alleviated or prevented the occurrence of hyperglycaemia, hypoinsulinaemia, hyperphagia, polydipsia, hyperlipidaemia, or cataract formation, but the slower body weight gain was not improved. " 03/01/2005 - "It may be concluded that vanadate at lowered doses administered in combination with Trigonella was the most effective in controlling the altered glucose metabolism and antioxidant status in diabetic lenses, these being significant factors involved in the development of diabetic complications, that reflects in the reduced lens opacity." 05/01/1993 - "Thus, vanadyl treatment was antioxidant in terms of cataract formation and reduced glutathione concentration in liver homogenates, pro-oxidant by reason of iron-stimulated TBARS formation and inconclusive with respect to glutamine synthetase activity. " 04/01/1983 - "Tellurite ion offered only 20% protection, while ferrous, zinc, lead, chromic, molybdate, tungstate, and vanadate ions provided no protection against selenium-induced cataract. "
4.	Diabetes Mellitus 12/06/1995 - "In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus." 11/01/1995 - "These data suggest that vanadate or related agents may have a potential role as adjunctive therapy in patients with diabetes mellitus." 03/01/1995 - "The aim of the present study was to investigate the effect of vanadate, at high (0-8 mmol l-1) and low (0-1.0 mmol l-1) physiological concentrations, on [125I]-insulin binding in the placenta of three groups of patients, namely from normal (N) controls, gestational diabetics (GDM) and women with risk factors in their medical history for developing diabetes mellitus (RF). " 07/01/1989 - "Although many studies in animal models and in cell cultures have shown that vanadate has insulin-like effects, it has not been studied in human diabetes mellitus. " 03/01/1995 - "The metalion vanadate has insulin-like effects and has been advocated for use in humans as a therapeutic modality for diabetes mellitus. "
5.	Body Weight (Weight, Body) 01/01/2011 - "In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats. " 05/01/2005 - "The body weight decreased as compared with untreated control (C group) in both vanadate treated groups (C + V and D + V) and in diabetic untreated rats (D group)--in all cases p < 0.01. " 03/01/2000 - "There was a consistent and significant increase in body weight of the vanadate-treated pre-diabetic NOD mice compared to the controls. " 03/01/1993 - "Vanadate treatment, however, did not affect the body weights of diabetic rats. " 07/01/1992 - "Since oral Na3VO4 caused decreases in food intake and body weight, vanadate-treated fa/fa rats were compared with controls, fed ad libitum, and pair-fed rats. "

Related Drugs and Biologics

1.	Sodium
2.	Vanadates (Orthovanadate)
3.	Glucose (Dextrose)
4.	Insulin (Novolin)
5.	Vanadium
6.	Ions
7.	U 78517F
8.	Edetic Acid (EDTA)
9.	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)
10.	Tyrosine (L-Tyrosine)

Related Therapies and Procedures

1.	Chemoprevention
2.	Lenses
3.	Oral Administration
4.	Injections
5.	Aftercare (After-Treatment)