Valine (L-Valine)

09/09/2010 - "Its in vivo efficacy was improved by preparing its (l)-valine prodrug, 65 (CKD-516), which together with greatly improved aqueous solubility has shown marked antitumor efficacy against both murine tumors (CT26 and 3LL) and human xenogratfs (HCT116 and HCT15) in mice."
04/01/1996 - "The tumors had, in comparison with the cortex, a significantly greater volume of distribution of valine. "
06/01/2006 - "Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents."
03/01/1998 - "However, the suppressive effect on tumor growth was maintained, as the tumor weight was suppressed to almost the same degree as that of rats administered only the valine-depleted solution."
12/01/1997 - "Moreover, the tumors from patients with the valine allele were more undifferentiated (P = 0.03). "

06/01/1996 - "These results demonstrate that increasing dietary valine for high-producing sows (21-d litter weights > 60 kg) results in improved litter weight gain. "
08/01/1974 - "The growth retardation is improved or corrected by adding valine to the diet, daily weight gain being proportional to dietary valine content over a range of 0-70 mumol/g. "
09/01/2014 - "The results showed that percentage weight gain (PWG), feed intake and feed efficiency of fish were the lowest in fish fed the valine-deficient diet (P < 0.05). "
05/01/2001 - "Weight gain increased quadratically (P < 0.05) with increasing levels of valine. "
03/01/2000 - "Sow backfat loss (P < .02), litter weaning weight (P < .04), and litter weight gain from d 2 to weaning (P > .05) increased as dietary valine increased. "

07/01/1988 - "Although the BCAA isoleucine and valine were taken up to a greater extent in sepsis, the overall BCAA uptake was not significantly greater in sepsis than in control (CON 6.92 +/- 2.15 mumol/g liver protein vs CLP 15.8 +/- 1.9 mumol/g liver protein). "
03/01/1985 - "However, valine was far less effective than leucine and isoleucine in maintaining systolic function in sepsis, due apparently to valine being a less efficient energy substrate for the cardiac muscle in a state of severe energy deficit. "
09/01/1985 - "In contrast, the clearances of branched-chain AA (BCAA) valine and isoleucine were maintained, and the clearance of leucine was higher (p less than 0.05) in trauma patients with sepsis than in those without. "
01/01/1996 - "Blood concentrations of branched chain amino acids (BCAA; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis. "
01/01/1980 - "Evidence is presented which suggests that fatal sepsis is associated with an increased release of endogenous valine and isoleucine into plasma, as well as increased plasma levels of tyrosine, proline, and methionine. "

02/01/1994 - "Thus, our studies suggest that without a glycan moiety at position 229, the valine residue at 214 is no longer restrictive for Mo-MuLV infection. "
11/01/2011 - "Despite these changes within the MDV and PDV, parasitic infection did not affect the ILR of valine within the hind limbs, and valine transport rates were largely unchanged. "
11/01/2011 - "In Exp. 1, parasitic infection increased (P = 0.03) the total valine irreversible loss rate (ILR) in the MDV and PDV. "
11/01/2011 - "Two experiments were conducted to determine the effects of parasitic infection on valine kinetics within the gastrointestinal tract and hind limbs of lambs fed fresh forages. "
01/01/2002 - "To discriminate between the effects of infection and of anorexia associated with infection, liver albumin synthesis was measured in well-fed rats, in rats injected with live Escherichia coli and in pair-fed rats at different stages of the inflammatory response (1, 6 and 10 days after infection) using a large dose of l-[1-(14)C]valine. "

04/01/2012 - "The ingestion of a valine (Val)-deficient diet results in a significant reduction of food intake and body weight within 24 h, and this phenomenon continues throughout the period over which such a diet is supplied. "
06/01/2004 - "Regression analysis (95% of response) indicated that valine at 0.72% of the diet maximized body weight gain, whereas 0.73% optimized feed conversion. "
12/01/2003 - "In order to determine the requirement of lactating sows for valine (Val) the effects of graded Val supplementations on feed intake, milk yield and changes of body weight of sows and piglets were examined using 54 multiparous sows over a total of 72 lactations (35 days). "
07/16/1986 - "Increasing the flooding amount of valine up to 17.1 mmol/5 kg body weight did not significantly alter protein synthesis rates in the jejunum, liver or skeletal muscle. "
07/16/1986 - "The fractional rates of protein synthesis were determined in tissues of animals receiving either 12.8 or 17.1 mmol valine/5 kg body weight. "