Anterior Uveitis

Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.

Also Known As:

Networked: 932 relevant articles (46 outcomes, 78 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation
2.	Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
3.	Vasculitis (Vasculitides)
4.	Ankylosing Spondylitis
5.	Reactive Arthritis (Reiter Disease)

Experts

1.	Rosenbaum, James T: 11 articles (11/2014 - 07/2002)
2.	Yang, Peizeng: 9 articles (07/2015 - 12/2002)
3.	Bora, Nalini S: 9 articles (03/2011 - 06/2004)
4.	Bora, Puran S: 9 articles (03/2011 - 06/2004)
5.	Kijlstra, Aize: 8 articles (07/2015 - 07/2009)
6.	Yang, Chang-Hao: 8 articles (01/2015 - 06/2004)
7.	Foster, C Stephen: 8 articles (11/2014 - 09/2003)
8.	Yang, Chung-May: 8 articles (06/2014 - 06/2004)
9.	Hou, Shengping: 6 articles (07/2015 - 01/2013)
10.	Lin, Chang-Pin: 6 articles (06/2014 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anterior Uveitis:

1.	valganciclovirFDA Link 07/01/2007 - "Valganciclovir may be very effective in treating CMV anterior uveitis, but its exact role can only be determined in larger studies with a longer follow-up." 01/01/2011 - "Valganciclovir may be effective in treating CMV anterior uveitis, but its exact role should be determined in larger studies with a longer follow-up. " 11/01/2015 - "Topical Valganciclovir for the Treatment of Hypertensive Anterior Uveitis." 07/01/2007 - "To describe 7 cases of unilateral, chronic and/or recurrent anterior uveitis caused by cytomegalovirus (CMV) in immunocompetent patients; to identify specific ophthalmologic characteristics; and to evaluate the clinical effect of valganciclovir treatment. " 01/01/2012 - "Five (38.5%) eyes had recurrence of anterior uveitis after valganciclovir was stopped and required retreatment with oral valganciclovir. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2010 - "Topical corticosteroids are effective in the control of anterior uveitis, but vary in strength, ocular penetration and side effect profile. " 06/01/2011 - "The authors present a series of 6 patients with pigment dispersion who were initially diagnosed as having acute anterior uveitis and treated with anti-inflammatory medication, including corticosteroids. " 01/01/2007 - "A 49-year-old woman was suffering from bilateral, noninfectious chronic anterior uveitis refractive to corticosteroids and immunosuppressive drugs. " 04/01/2001 - "Four weeks later, the patient presented anterior uveitis treated by topical corticosteroids. " 02/01/1999 - "Two weeks later, an anterior uveitis occurred in the left eye, which responded to topical corticosteroids. "
3.	prednisolone acetateFDA LinkGeneric 12/01/2010 - "A 49-year-old black man presented with a traumatic anterior uveitis recalcitrant to traditional prednisolone acetate 1% treatment. " 01/01/2008 - "With the diagnosis of right anterior uveitis, topical prednisolone acetate (1%) was started, and her symptoms completely resolved within 1 week. " 06/01/1980 - "Frequent topical administration of 1.0% prednisolone acetate during the first 100 hours of the experimental anterior uveitis produced a significant decrease both in protein and in the number of leukocytes in the anterior chamber." 10/01/2010 - "Difluprednate provides effective treatment for anterior uveitis and requires less frequent dosing than prednisolone acetate. " 05/01/2004 - "Rimexolone 1% ophthalmic suspension is as effective as and safer than prednisolone acetate 1% ophthalmic suspension in the treatment of anterior uveitis."
4.	infliximab (Remicade)FDA Link 01/01/2012 - "Anterior uveitis improved after infliximab administration. " 01/01/2013 - "A case of severe recurrent anterior uveitis OU in a patient with AS with infliximab was successfully treated. " 01/01/2012 - "To describe a patient with Behçet's disease and anterior uveitis, which was not cured by local and systemic corticosteroid treatments, who underwent trabeculotomy one week after infliximab administration. " 05/01/2015 - "Infliximab-induced anterior uveitis in a patient with ulcerative Colitis." 01/01/2013 - "We describe a HLA-B27-positive Japanese man with recurrent severe anterior uveitis OU and ankylosing spondylitis (AS) who was successfully treated with infliximab. "
5.	loteprednol etabonate (loteprednol)FDA Link 11/01/2003 - "Examination revealed acute bilateral nongranulomatous anterior uveitis that was effectively treated with loteprednol. " 03/01/2000 - "Lotemax (0.5% LE) has been demonstrated as effective in reducing the signs and symptoms of giant papillary conjunctivitis (GPC), acute anterior uveitis and inflammation following cataract extraction with intraocular lens (IOL) implantation. " 05/01/1999 - "To compare the safety and efficacy of loteprednol etabonate 0.5% ophthalmic suspension with prednisolone acetate 1.0% ophthalmic suspension in reducing the ocular signs and symptoms associated with acute anterior uveitis. " 05/01/1999 - "Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis. "
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/01/2005 - "Treatment of AS patients with biologic agents directed against TNFalpha is associated with a significant decrease in the number of anterior uveitis flares. " 07/01/2002 - "Here, we review recent insights into anterior uveitis with regard to clinical presentation, immune mechanisms, genetics, and anti-tumor necrosis factor therapy." 02/01/2012 - "The main focus is on the effect of TNF-α (tumor necrosis factor-α) which is a pro-inflammatory molecule found in the intraocular milieu during allograft rejection and anterior uveitis. " 03/01/2010 - "TNF-alpha is elevated in the cornea and aqueous humor during allograft rejection and anterior uveitis. " 08/01/2005 - "To estimate the incidence of anterior uveitis in patients with ankylosing spondylitis (AS) who underwent anti-tumor necrosis factor (anti-TNF) therapy, using data from recently performed trials. "
7.	CurcuminIBA 01/01/2010 - "Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. " 06/01/1999 - "Efficacy of curcumin in the management of chronic anterior uveitis." 06/01/1999 - "Curcumin, obtained from rhizomes of Curcuma longa, was administered orally to patients suffering from chronic anterior uveitis (CAU) at a dose of 375 mg three times a day for 12 weeks. " 01/01/2010 - "In conclusion, our study is the first to report the potential therapeutic role of curcumin and its efficacy in eye relapsing diseases, such as anterior uveitis, and points out other promising curcumin-related benefits in eye inflammatory and degenerative conditions, such as dry eye, maculopathy, glaucoma, and diabetic retinopathy." 06/01/2009 - "Based on early cell culture and animal research, clinical trials indicate curcumin may have potential as a therapeutic agent in diseases such as inflammatory bowel disease, pancreatitis, arthritis, and chronic anterior uveitis, as well as certain types of cancer. "
8.	Retinaldehyde (Retinal)IBA 10/01/2015 - "[The clinical investigation of peripheral retinal changes of anterior uveitis]." 03/01/2013 - "We hypothesized that anterior uveitis may contribute to the growth and maintenance of retinal lesions." 12/01/2012 - "Anterior uveitis, retinal examination, histopathological evaluation and primary clinical outcome were observed during systemic treatment. " 09/01/2012 - "To implement non-invasive ocular coherence tomography (OCT) for obtaining quantitative and qualitative data in the assessment of changes in macular morphology and peripapillary retinal nerve fiber layers in eyes with acute anterior uveitis. " 01/01/2012 - "To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. "
9.	Prednisolone (Predate)FDA LinkGeneric 12/01/2005 - "While tapering prednisolone, anterior uveitis developed, which was improved with topical steroid. " 01/01/2015 - "Oral prednisolone, 1 mg/kg body weight was given 7d prior to surgery, continued post-operatively and tapered according to the inflammatory response over 4-6wk in patients with previously documented macular edema, recurrent uveitis, chronic anterior uveitis and intermediate uveitis. " 10/01/2010 - "In this phase 3, multicenter, randomized, noninferiority trial, 90 patients with endogenous anterior uveitis [>10 anterior chamber (AC) cells and an AC flare score of ≥2 in at least 1 eye] received either difluprednate 4x /day (QID) (n=50) or prednisolone 8x/day (n=40) for 14 days, followed by a 2-week tapering regimen. " 01/01/2015 - "Subsequently, he was diagnosed with bilateral anterior uveitis (vision 20/30 bilaterally) and started on prednisolone and cyclopentolate. " 04/01/2014 - "Comparison of efficacy and ocular surface toxicity of topical preservative-free methylprednisolone and preserved prednisolone in the treatment of acute anterior uveitis."
10.	rimexolone (Vexol)FDA Link 05/01/2004 - "Rimexolone 1% ophthalmic suspension is as effective as and safer than prednisolone acetate 1% ophthalmic suspension in the treatment of anterior uveitis." 05/01/2004 - "Rimexolone is as effective as prednisolone acetate ophthalmic suspension in the treatment of anterior uveitis. " 05/01/2004 - "Efficacy and safety of 1% rimexolone versus 1% prednisolone acetate in the treatment of anterior uveitis--a randomized triple masked study." 09/01/2005 - "To compare the efficacy and safety of prednisolone acetate 1% vs. rimexolone 1% ophthalmic suspension in the treatment of acute anterior uveitis (AAU) in HLA-B27+ patients. " 05/01/2004 - "To evaluate the efficacy and safety of 1% rimexolone versus 1% prednisolone acetate ophthalmic suspension in the treatment of anterior uveitis. "

Therapies and Procedures

1.	Phacoemulsification 07/01/2013 - "Phacoemulsification with intraocular lens implantation in patients with anterior uveitis." 02/01/2010 - "A 61-year-old male developed recurrent anterior uveitis over a period of 8 months after an uncomplicated phacoemulsification and posterior chamber intraocular lens implantation surgery. " 04/01/2015 - "A;45 year-old female with corneal endothelial decompensation and a mature cataract, and history of anterior uveitis underwent simultaneous phacoemulsification, IOL implantation and DMEK. " 07/01/2013 - "Patients with a history of anterior uveitis and cataract having phacoemulsification with PC IOL implantation had excellent visual results with a relatively low complication rate. " 07/01/2013 - "Consecutive patients with anterior uveitis and cataract were prospectively studied for outcomes after phacoemulsification and PC IOL implantation. "
2.	Intraocular Lenses (Intraocular Lens) 12/01/2013 - "Case description of a 34 year old woman with chronic granulomatous anterior uveitis following implantation of a phakic anterior chamber intraocular lens (IOL). " 01/01/1989 - "The paper analyses results after experimental investigations for detection of some mechanisms of postoperative anterior uveitis after lens extraction and implantation of intraocular lens. " 07/01/2011 - "Immediate postoperative complication was striate keratopathy 157(10.7%), late were chronic anterior uveitis 3 (0.2%), corneal decompensation 2 (0.1%) choroidal and retinal detachment 1 (0.06%) each, Intraocular Lens (IOL) subluxation 4 (0.2%) and Posterior capsular opacification 40 (2.7%). " 01/01/2005 - "We report the first case of severe unilateral anterior uveitis in a patient with breast cancer and an intraocular lens. " 11/01/1999 - "To assess whether cataract surgery and intraocular lens (IOL) implantation in patients with anterior uveitis interfere with the natural course of the ocular disease. "
3.	Intravitreal Injections 01/01/2015 - "We present a new application of optical coherence tomography (OCT) and OCT-based microangiography (OMAG) to a rat model of acute anterior uveitis induced by intravitreal injection of a killed mycobacterial extract. " 09/01/2008 - "Anterior uveitis was induced in rabbits by intravitreal injection of lipopolysaccharide from Escherichia coli after pretreatment with C. " 01/01/2013 - "Acute anterior uveitis following intravitreal injection of bevacizumab." 05/01/2008 - "We report on an acute nong-ranulomatous anterior uveitis after intravitreal injection of bevacizumab. " 09/01/2006 - "Case of anterior uveitis after intravitreal injection of bevacizumab."
4.	Cataract Extraction 11/01/1999 - "Long-term follow-up of anterior uveitis after cataract extraction and intraocular lens implantation." 07/01/1985 - "The incidence of mild anterior uveitis (three out of seven eyes) and hyphaema (two out of seven eyes) was greater than usual with this type of cataract extraction but no more than expected after trabeculectomy. " 01/01/1980 - "Cataract extraction and iris clip lens implantation in an 88-year-old woman were followed by hyphaema, anterior uveitis and organised exudates around the implant. " 12/01/2013 - "We report a 6-year-old boy with anterior uveitis associated with juvenile idiopathic arthritis (JIA) who underwent cataract extraction in his right eye. " 03/01/1987 - "Aqueous humor from patients with anterior uveitis induced significantly more monocyte migration than did aqueous humor from two sets of controls (either patients undergoing cataract extraction or patients with posterior uveitis). "
5.	Laser In Situ Keratomileusis (LASIK) 07/01/2009 - "Indication of LASIK in patients at high risk of developing recurrent flares of acute anterior uveitis, such as those with spondyloarthropathies, should be carefully considered." 07/01/2009 - "Acute anterior uveitis may be a predisposing factor for late-onset DLK after LASIK surgery. " 07/01/2009 - "This case demonstrates that severe anterior uveitis may develop after LASIK and needs prompt and vigorous management for resolution." 07/01/2009 - "Fibrinous anterior uveitis following laser in situ keratomileusis." 06/01/2005 - "These two cases demonstrated acute corneal fluid accumulation associated with episodes of acute anterior uveitis in eyes that had undergone LASIK. "