Uteroglobin

A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.

Also Known As:

Networked: 203 relevant articles (4 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kimura, Shioko: 7 articles (12/2012 - 03/2002)
2.	Mukherjee, Anil B: 4 articles (03/2008 - 03/2005)
3.	Zhang, Zhongjian: 4 articles (03/2008 - 03/2005)
4.	Han, Sung Koo: 3 articles (09/2010 - 04/2003)
5.	Kim, Young Whan: 3 articles (09/2010 - 04/2003)
6.	Lee, Choon-Taek: 3 articles (09/2010 - 04/2003)
7.	Shim, Young-Soo: 3 articles (09/2010 - 04/2003)
8.	Yoo, Chul-Gyu: 3 articles (09/2010 - 04/2003)
9.	Choi, Moonsuk: 3 articles (06/2006 - 03/2005)
10.	Wang, Jing: 2 articles (12/2021 - 01/2020)

Related Diseases

1.	Hyperplasia 12/01/2001 - "Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells." 08/01/2001 - "Adenoviral mediated uteroglobin gene transfer to the adventitia reduces arterial intimal hyperplasia." 12/01/2000 - "We hypothesize that induction of uteroglobin expression in the artery wall by local adenoviral gene transfer will decrease neointimal hyperplasia in the rat carotid artery after balloon injury. " 12/01/2000 - "Adenoviral-mediated uteroglobin gene transfer inhibits neointimal hyperplasia after balloon injury in the rat carotid artery." 08/01/2001 - "The aim of this study was to investigate the feasibility of gene transfer of uteroglobin, a potent anti-inflammatory and immunomodulatory agent, via adenoviral mediated gene transfer to the adventitia in the mouse carotid ligation injury model and also to investigate the efficacy of uteroglobin in reducing neointimal hyperplasia. "
2.	Neoplasms (Cancer) 03/15/2006 - "Mandal et al. (1999) Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene. " 03/15/2006 - "Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion." 07/01/2003 - "Uteroglobin was confirmed to be abundantly expressed in normal lung and the different lung tumors showed down-regulated uteroglobin expression. " 04/01/2003 - "Recent experimental evidence indicates that uteroglobin has an inhibitory effect on the proliferation and invasion of cancer cells. " 09/01/2002 - "Uteroglobin -/- knockout mice appear to be extremely cancer prone. "
3.	Genetic Predisposition to Disease (Genetic Predisposition) 01/01/2004 - "The gene for Clara cell secretory protein (CC16) is an ideal candidate for investigating genetic predisposition to asthma because of its role in the airway as an anti-inflammatory molecule, differences in its levels between asthmatics and healthy controls, and its genetic location (11q13). " 01/01/2000 - "Human uteroglobin gene polymorphisms and genetic susceptibility to asthma." 01/01/2023 - "The aim of this paper was to present the current sources of exposure to silica dust and summarize the updates on risk factors (e.g., socioeconomic status, genetic susceptibility) and sex differences, silico-tuberculosis, prognostic markers including 16-kDa Clara cell secretory protein, antifibrotic treatment, and other therapeutic possibilities with promising results. "
4.	Prostatic Neoplasms (Prostate Cancer) 09/01/2002 - "In this paper, we will briefly discuss the therapeutic potential of uteroglobin-based strategies for managing prostate cancer." 12/01/1997 - "Loss of uteroglobin expression in prostate cancer: relationship to advancing grade." 09/01/2002 - "Uteroglobin: a potential novel tumor suppressor and molecular therapeutic for prostate cancer." 12/01/1997 - "We have shown previously that the secretory protein uteroglobin (UG) is highly expressed in normal human prostate tissue but this expression is either lost or altered in human prostate cancer cell lines. "
5.	Tuberculosis (Tuberculoses) 01/01/2023 - "The aim of this paper was to present the current sources of exposure to silica dust and summarize the updates on risk factors (e.g., socioeconomic status, genetic susceptibility) and sex differences, silico-tuberculosis, prognostic markers including 16-kDa Clara cell secretory protein, antifibrotic treatment, and other therapeutic possibilities with promising results. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Surface-Active Agents (Surfactants)
3.	Silicon Dioxide (Silica)
4.	Uteroglobin
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Messenger RNA (mRNA)
7.	Progesterone
8.	Progesterone Receptors (Progesterone Receptor)
9.	Immunoglobulin E (IgE)
10.	Chymases (Chymase)

Related Therapies and Procedures

1.	Ligation
2.	Lung Transplantation
3.	One-Lung Ventilation
4.	Intravenous Administration
5.	Stem Cell Transplantation