Uterine Rupture

A complete separation or tear in the wall of the UTERUS with or without expulsion of the FETUS. It may be due to injuries, multiple pregnancies, large fetus, previous scarring, or obstruction.

Also Known As:

Networked: 823 relevant articles (7 outcomes, 69 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cicatrix (Scar)
2.	Pain (Aches)
3.	Rupture
4.	Uterine Inertia
5.	Eclampsia

Experts

1.	Macones, George A: 12 articles (01/2012 - 03/2005)
2.	Stamilio, David M: 11 articles (10/2014 - 03/2005)
3.	Sheiner, Eyal: 8 articles (12/2013 - 08/2003)
4.	Varner, Michael W: 7 articles (09/2015 - 10/2006)
5.	Cahill, Alison G: 7 articles (01/2012 - 10/2006)
6.	Spong, Catherine Y: 7 articles (02/2011 - 10/2006)
7.	Odibo, Anthony O: 6 articles (01/2012 - 11/2007)
8.	Mercer, Brian M: 6 articles (02/2011 - 10/2006)
9.	Thorp, John M: 6 articles (02/2011 - 10/2006)
10.	Landon, Mark B: 6 articles (02/2011 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uterine Rupture:

1.	Misoprostol (Cytotec)FDA LinkGeneric 08/01/2011 - "No serious adverse complications such as uterine rupture were found This experience suggests that misoprostol has a high efficacy for pregnancy termination with acceptable minor side effects and it is relatively safe when used with precaution." 05/01/2009 - "To estimate the risk of uterine rupture in women with prior cesarean delivery undergoing second-trimester abortion with misoprostol and number needed to harm, I pooled the results of all 16 studies. " 02/01/2014 - "The use of misoprostol in women with prior cesarean delivery or major uterine surgery has been associated with an increase in uterine rupture and therefore should be avoided (LE4). " 09/01/2013 - "Misoprostol appears to increase the risk of uterine rupture strongly (LE4). " 01/01/2013 - "Secondary outcomes were time from induction to abortion, total dose of misoprostol used, and occurrence of uterine rupture. "
2.	Dinoprostone (PGE2)FDA Link 01/01/2007 - "In women with a scarred uterus, prostaglandin E2 induction of labour is a risk factor for uterine rupture. " 06/01/2005 - "Medical induction of labor with prostaglandin E2 (dinoprostone) is associated with an increased risk of uterine rupture and should not be used except in rare circumstances and after appropriate counseling (II-2B). " 02/01/2005 - "Medical induction of labour with prostaglandin E2 (dinoprostone) is associated with an increased risk of uterine rupture and should not be used except in rare circumstances and after appropriate counselling (II-2B). " 07/01/2004 - "Medical induction of labour with prostaglandin E2 (dinoprostone) is associated with an increased risk of uterine rupture and should not be used except in rare circumstances after appropriate counselling. " 07/01/2002 - "We recommend that all VBAC patients using a PGE2 vaginal insert be closely monitored for evidence of uterine rupture."
3.	A-factor (Streptomyces)IBA 10/01/2007 - "Indicated repeat cesarean delivery increased the risk of uterine rupture by a factor of 5 (odds ratio 5.1, 95% confidence interval 1.49-17.44). " 07/01/1990 - " Complications of symphysiotomy can be virtually eliminated if the procedure is performed only when 1/3 or more of the fetal head has entered the pelvic brim, the fetal head is not felt prominent in from of the symphysis, and the cervix is dilated beyond 7 cm. Since this procedure does not scar the uterus, the concern of future uterine rupture that exists with cesarean section is not a factor. "
4.	Fentanyl (Sublimaze)FDA LinkGeneric 05/01/1997 - "The pain of uterine rupture was not masked by the addition of fentanyl 25 micrograms to bupivacaine 0.25% 6 ml but was relieved by bupivacaine 0.375% 6 ml."
5.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 05/01/1997 - "The pain of uterine rupture was not masked by the addition of fentanyl 25 micrograms to bupivacaine 0.25% 6 ml but was relieved by bupivacaine 0.375% 6 ml."
6.	Oxytocin (Pitocin)FDA LinkGeneric 07/01/2008 - "These findings support a maximum oxytocin dose of 20 mU/min in VBAC trials to avoid an unacceptably high risk of uterine rupture." 02/01/2008 - "The aim of our study was to explore the views of consultant obstetricians in the south-west of England on the use of prostaglandin and oxytocin in women undergoing vaginal birth after caesarean delivery (VBAC), and assess how the perceived risk of uterine rupture in such a cohort of women affected their practice. " 06/01/1995 - "Two case presentations of oxytocin-associated unscarred uterine rupture and review of pertinent literature are used to study risk factors and accompanying clinical characteristics. " 01/01/2014 - "Intrapartum management of TOLAC differs primarily in the need for caution with induction of labour in women with an unfavourable cervix, the avoidance of overstimulation with oxytocin augmentation, and surveillance for prompt recognition of the rare case of uterine rupture. " 09/01/2013 - "The increased risk of uterine rupture associated with oxytocin use is dose-dependent (LE3). "
7.	ProstaglandinsIBA 04/01/2003 - "Recent large, retrospective, population-based cohort studies examined the maternal and neonatal safety of trial of labour compared with elective repeat cesarean delivery, and confirmed that the risks of uterine rupture and neonatal mortality were significantly increased after trial of labour, particularly when induced with prostaglandins. " 01/01/2013 - "In comparison with patients with spontaneous labor, inducing cervical ripening with low-dose prostaglandins in case of unfavourable cervix is not associated with appreciable increase in uterine rupture, maternal or perinatal morbidity." 01/01/2013 - "Uterine rupture (0.7% compared with 0.8%, OR 1.1, 95% CI 0.4-3.4, p=0.88), maternal (0.9% compared with 1.2%, OR 1.3, 95% CI 0.5-3.2, p=0.63) and perinatal (0.3% compared with 0.8%, OR 2.4, 95% CI 0.7-8.5, p=0.18) morbidity rates did not differ significantly between patients with spontaneous onset of labor and those receiving prostaglandins, nor did these rates differ according to the planned mode of delivery. " 12/01/2012 - "Labor induction is associated with an increased risk of uterine rupture that could be estimated at 1% with oxytocine and 2% with vaginal prostaglandins (Level 2). " 10/01/2010 - "  Higher risks of uterine rupture have been reported among women attempting vaginal birth after caesarean (VBAC) particularly following induction with prostaglandins, compared with women who do not labour. "
8.	CollagenIBA 08/01/2003 - "Collagen content and growth factor immunoexpression in uterine lower segment of type IA osteogenesis imperfecta: Relationship with recurrent uterine rupture in pregnancy." 05/01/2014 - "Pregnant uterine rupture in mid-trimester could be repaired with suture and overlapping of collagen fleece in the absence of placenta percreta. " 07/01/2001 - "This is a rare inherited collagen disorder that has been reported to have a high pregnancy-related morbidity and mortality, particularly from uterine rupture and uncontrolled bleeding from friable vessels, coagulopathy and major vessel rupture. " 10/01/2007 - "Successful continuation of pregnancy after repair of a midgestational uterine rupture with the use of a fibrin-coated collagen fleece (TachoComb) in a primigravid woman with no known risk factors." 10/01/2007 - "We report the first case of successful continuation of pregnancy after repair of a midgestational uterine rupture with the use of a fibrin-coated collagen fleece (TachoComb, Nycomed, Linz, Austria). "
9.	Acute fatty liver of pregnancyIBA 01/01/2013 - "UKOSS studies from which data on case women were obtained included amniotic fluid embolism, acute fatty liver of pregnancy, eclampsia, peripartum hysterectomy, therapies for peripartum haemorrhage and uterine rupture. " 10/01/2015 - "Obstetrical DIC has been associated with a series of pregnancy complications including the following: (1) acute peripartum hemorrhage (uterine atony, cervical and vaginal lacerations, and uterine rupture); (2) placental abruption; (3) preeclampsia/eclampsia/hemolysis, elevated liver enzymes, and low platelet count syndrome; (4) retained stillbirth; (5) septic abortion and intrauterine infection; (6) amniotic fluid embolism; and (7) acute fatty liver of pregnancy. "
10.	Connective Tissue Growth FactorIBA 08/01/2003 - "The purpose of this study was to evaluate collagen content and platelet-derived growth factor, vascular endothelial growth factor, and connective tissue growth factor expression in the myometrium of the uterine lower segment from a patient with type IA osteogenesis imperfecta with recurrent uterine rupture and to evaluate the existence of a relationship between the rare recurrent uterine rupture and the tissue disorders of type IA osteogenesis imperfecta. "

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 02/01/2014 - "The aim of our study was to examine the validity of registration of uterine rupture in the MBR within the population of pregnant women with prior cesarean section by conducting a review of the medical records. " 11/01/2011 - "To determine the risk of uterine rupture for women undergoing trial of labour (TOL) with both a prior caesarean section (CS) and a vaginal delivery. " 11/01/2011 - "Risk of uterine rupture in women undergoing trial of labour with a history of both a caesarean section and a vaginal delivery." 07/01/2010 - "To study risk factors for uterine rupture (UR) in women with one previous caesarean section (CS) undergoing a vaginal birth after CS (VBAC). " 06/01/2010 - "Trial of labour carried greater risk and graver outcome of uterine rupture than elective repeated caesarean section, although absolute risks were low. "
2.	Hysterotomy 04/01/1992 - "The very low incidence of uterine rupture since segmental hysterotomy has become widespread and the improved fetal and maternal prognosis are all reasons to prefer delivery by the genital tract. " 10/01/2011 - "Single- versus double-layer closure of the hysterotomy incision during cesarean delivery and risk of uterine rupture." 03/17/1973 - " It would seem likely by analogy with classical and lower segment Casarean section incisions that the risk of uterine rupture in a subsequent pregnancy will be considerably reduced by this technique, which I now use whenever possible instead of the vertical upper segment incision usually employed for hysterotomy." 03/17/1973 - "321) that there is a substantial risk of uterine rupture in pregnancy after hysterotomy is reinforced by a case recently under my care. " 02/10/1973 - "Due weight should be given to the risks of subsequent early pregnancy and uterine rupture before terminating a pregnancy by the operation of hysterotomy without sterilization."
3.	Sutures (Suture) 01/01/2011 - "This report evaluates the efficacy of a new method of adenomyomectomy, where adenomyotic tissues are radically excised and the uterine wall is reconstructed by a triple-flap method, without overlapping suture lines, to prevent uterine rupture in subsequent pregnancies. " 11/01/1999 - "TO review the incidence of ruptured uterus at Women's Hospital, Hamad Medical Corporation (HMC), highlight the management approach of suture repair in relation to maintaining the patient's future fertility, and study subsequent pregnancy outcome and the risk of recurrent uterine rupture. " 09/01/2011 - "Uterine rupture at 33 weeks following previous B-lynch suture." 08/01/2011 - "Uterine rupture following previous uterine compression suture." 06/01/2010 - "Antenatal catastrophic uterine rupture at 32 weeks of gestation after previous B-Lynch suture."
4.	Drug Therapy (Chemotherapy) 05/01/1994 - "A 27-year-old primiparous woman with a history of gestational trophoblastic neoplasia treated successfully with chemotherapy experienced intrapartum uterine rupture with subsequent neonatal death. " 12/01/2009 - "Two cases of uterine rupture in low-risk GTN conservatively managed with primary uterine rupture repair using hemostatic stitches and postoperative single-agent chemotherapy are presented. "
5.	Symphysiotomy 07/01/1990 - " Complications of symphysiotomy can be virtually eliminated if the procedure is performed only when 1/3 or more of the fetal head has entered the pelvic brim, the fetal head is not felt prominent in from of the symphysis, and the cervix is dilated beyond 7 cm. Since this procedure does not scar the uterus, the concern of future uterine rupture that exists with cesarean section is not a factor. "