Uterine Prolapse (Vaginal Prolapse)

Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.

Also Known As:

Networked: 479 relevant articles (18 outcomes, 55 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cystocele
2.	Prolapse
3.	Rectocele
4.	Stress Urinary Incontinence
5.	Overactive Urinary Bladder (Overactive Bladder)

Experts

1.	Vierhout, Mark E: 7 articles (01/2015 - 11/2004)
2.	Huang, Kuan-Hui: 5 articles (07/2015 - 10/2003)
3.	Iglesia, Cheryl B: 5 articles (05/2015 - 01/2009)
4.	Moore, Robert D: 5 articles (10/2012 - 05/2003)
5.	Kung, Fu-Tsai: 4 articles (07/2015 - 10/2003)
6.	Auge, Antonio Pedro Flores: 4 articles (03/2015 - 02/2009)
7.	den Boon, Jan: 4 articles (01/2015 - 01/2011)
8.	Richter, Holly E: 4 articles (11/2014 - 01/2009)
9.	Davila, G Willy: 4 articles (01/2013 - 07/2009)
10.	Aguilar, Vivian C: 4 articles (01/2013 - 05/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uterine Prolapse:

1.	Polypropylenes (Polypropylene)IBA 07/01/2014 - "The aim of the present study was to evaluate the safety and efficacy of a ″Cravat″ technique for the management of uterine prolapse in patients who want to preserve uterus, involving suspension of the uterus from the sacral promontory by using polypropylene mesh. " 12/01/1996 - "The efficacy of Marlex mesh in the repair of severe, recurrent vaginal prolapse of the anterior midvaginal wall." 01/01/2013 - "Mesh erosions were reported in 11.4% (64/563), with surgical interventions being performed in 6.8% (32/470).Data from three trials compared native tissue repairs with a variety of total, anterior, or posterior polypropylene kit meshes for vaginal prolapse in multiple compartments. " 04/01/2012 - "This study was designed to evaluate clinical outcomes ≥2 years following surgery with polypropylene mesh and vaginal support device (VSD) in women with vaginal prolapse, in a prospective, multi-center setting. " 01/01/2012 - "  The aim of this study was to evaluate the efficacy and safety of polypropylene mesh for uterine preservation during pelvic reconstruction in patients with severe uterine prolapse. "
2.	CollagenIBA 01/01/1993 - "Histomorphologic studies of the pelvic floor have demonstrated that, in some women, abnormal collagen types are responsible for vaginal prolapse and accompanying SUI. " 11/01/2014 - "Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair." 02/01/2010 - "Uterine prolapse is associated with connective tissue alterations including total amount of connective tissue components and diameter and distribution of collagen fibers." 01/01/2006 - "To compare tissue markers of collagen metabolism in the uterosacral ligaments with those in vaginal tissue in women with uterine prolapse. " 01/01/2006 - "Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse."
3.	LavsanIBA 07/01/2002 - "Abdominal sling surgery is defined as attachment of either the connective tissue graft (fascia lata) or some synthetic material (Mersilene) to the anterior wall of the exposed vaginal vault following total hysterectomy or to the posterior wall of the uterine cervix in total and subtotal uterine prolapse, whereas the other end is attached to the anterior longitudinal ligament extending along the anterior surface of the vertebrae. " 05/01/2005 - "The purpose of this study was to compare the efficacy of a Mersilene mesh suburethral sling for occult stress urinary incontinence (SUI) and intrinsic sphincter deficiency (ISD) in women with severe vaginal prolapse of the anterior compartment to the posterior/apical compartment. " 01/01/1963 - "[SURGICAL CORRECTION OF UTERINE AND VAGINAL PROLAPSE WITH THE USE OF CAPRON AND LAVSAN]."
4.	tolterodine (Detrol)FDA Link 11/01/2007 - "The aim of this study was to assess the efficacy of tolterodine in women with overactive bladder (OAB) and concomitant anterior vaginal prolapse. "
5.	Messenger RNA (mRNA)IBA 11/01/2010 - "With regard to menopausal status, there was no significant difference in MMP-2 and TIMPs mRNA expression between premenopausal and postmenopausal women with uterine prolapse. " 10/01/2010 - "FIB-3 mRNA expression and FIB-3 staining intensity was similar in the USL of women with and without uterine prolapse {[(FIB-3 mean +/- SD mRNA relative units) 0.45 +/- 0.41 vs. 0.46 +/- 0.82, NS] and [Intensity score, median (range), 1(0-1) vs. 1(0-1), NS]}. " 10/01/2010 - "Both FIB-5 mRNA expression and FIB-5 staining intensity was significantly decreased in USL from women with uterine prolapse compared to women without prolapse {[(FIB-5 mean +/- SD mRNA relative units) 0.07 +/- 0.02 vs. 0.26 +/- 0.20, P = 0.02] and [Intensity score, median (range), 0(0-2) vs. 3(2-3), P = 0.002]}. " 04/01/2012 - "When compared with controls, women with uterine prolapse had a significantly greater level of MMP-2 immunoreactivity and mRNA expression, but less TIMP-2 and α-1 antitrypsin immunoreactivity and mRNA expression in their uterosacral ligaments. " 04/01/2012 - "However, neutrophil elastase mRNA expression was similar between uterine prolapse and control tissue. "
6.	Polytetrafluoroethylene (Teflon)FDA Link 07/01/1993 - "Abdominal-retroperitoneal sacral genito-colpopexy using the expanded polytetrafluoroethylene (ePTFE) soft tissue patch has been found to be highly effective for repair of genito-vaginal prolapse. " 01/01/1994 - "[Surgical correction of recurrent uterine prolapse by means of the PTFE (1) plate]." 06/01/1994 - "Massive vaginal prolapse in ten post-hysterectomy women was treated by expanded polytetrafluoroethylene graft along the course of the round ligaments to anchor the vaginal vault to the lateral abdominal wall. "
7.	Tissue Inhibitor of Metalloproteinase-2IBA 04/01/2012 - "Our results showed that there was a close relationship between expressions of MMP-2, TIMP-2, and α-1 antitrypsin in uterosacral ligament and the occurrence of uterine prolapse." 04/01/2012 - "When compared with controls, women with uterine prolapse had a significantly greater level of MMP-2 immunoreactivity and mRNA expression, but less TIMP-2 and α-1 antitrypsin immunoreactivity and mRNA expression in their uterosacral ligaments. " 11/01/2010 - "A significantly higher expression of MMP-2 mRNA and lower expression of TIMP-2 mRNA were found in uterosacral ligament in uterine prolapse women compared to controls. " 11/01/2010 - "An increase in MMP-2 mRNA and a decrease in TIMP-2 mRNA expression in uterosacral ligament are related to uterine prolapse in women without urinary incontinence."
8.	Muscarinic AntagonistsIBA 11/01/2007 - "Women with OAB and significant anterior vaginal prolapse should be informed of a reduced efficacy of antimuscarinics in treating their urinary symptoms."
9.	TitaniumIBA 06/01/2008 - "Vaginal prolapse repair surgery augmented by ultra lightweight titanium coated polypropylene mesh." 06/01/2008 - "To determine the safety and efficacy of ultra lightweight titanium coated polypropylene mesh to augment conventional vaginal prolapse repair in women with recurrent symptomatic prolapse stage II or more or primary prolapse stage III or more. "
10.	4-azido-2,3,5,6-tetrafluoropyridine (ATFP)IBA 03/01/2005 - "Since VPVR can restore the normal lateral attachment of the pubocervical fascia to pelvic side wall at ATFP, it is a reasonable, safe and effective procedure to correct severe anterior vaginal prolapse and cystocele."

Therapies and Procedures

1.	Hysterectomy 01/01/2009 - "This procedure has increasingly become an effective treatment of uterine prolapse in women who have no indication for hysterectomy." 10/01/2015 - "This is secondary analysis of single center randomized controlled study comparing two standard procedures for vaginal prolapse after hysterectomy in patients with levator avulsion injury. " 01/01/2015 - "The study included 102 patients who underwent hysterectomy to correct grade 3-4 uterine prolapse and 105 patients who underwent hysterectomy for other causes. " 07/01/2012 - "The operations, either uterine suspension or hysterectomy, due to the diagnosis of uterine prolapse were indentified into the study. " 05/01/2012 - "The aim of this study is to assess the impact of hysterectomy on durability of uterine prolapse repair by comparing hysterectomy/uterosacral cuff suspension (VH) to a new vaginal uterosacral hysteropexy (USH). "
2.	Vaginal Hysterectomy 01/01/2011 - "The SAVE U trial is a randomized multicenter trial that will provide evidence whether the efficacy of sacrospinous fixation is similar to vaginal hysterectomy in women with uterine prolapse stage 2 or higher. " 01/01/2011 - "Several studies have shown that sacrospinous fixation in case of uterine prolapse is a safe and effective alternative to vaginal hysterectomy. " 07/01/2011 - "The aim of this study was to evaluate the efficacy of a new technique of suspending the vaginal vault at vaginal hysterectomy (VH) for total uterine prolapse. " 11/01/2015 - "We now report a pilot randomized study comparing laparoscopic hysteropexy (LH) with vaginal hysterectomy (VH) for the surgical management of uterine prolapse. " 09/01/2015 - "Aim of the study was to estimate the incidence of unexpected premalignant gynecological lesions in women undergoing vaginal hysterectomy for utero-vaginal prolapse. "
3.	Sutures (Suture) 10/01/2004 - "The laparoscopy suture hysteropexy or colpopexy is effective and safe in the management of symptomatic uterine prolapse. " 06/01/2001 - "The laparoscopic suture hysteropexy is effective and safe in the management of symptomatic uterine prolapse. " 07/01/2015 - "Postoperatively, a stay suture was maintained in the vulva for 2 weeks, resulting in permanent reduction of the vaginal prolapse. " 01/01/2015 - "The effect of suture characteristics on short-term morbidity after vaginal prolapse surgery." 11/01/2012 - "Short-term complications after vaginal prolapse surgery: do suture characteristics influence morbidity?"
4.	Transplants (Transplant) 12/01/2006 - "The objective of the study was to determine the efficacy of the vaginal paravaginal repair using porcine dermal graft reinforcement for the correction of advanced anterior vaginal prolapse. " 09/01/2010 - "This study seeks to compare the small intestine submucosa (SIS) graft with traditional colporrhaphy (TC) for surgical treatment of anterior vaginal prolapse. " 03/01/2013 - "Martius graft for management of exposed vaginal prolapse mesh." 08/01/2011 - "When using a non-crosslinked biologic graft for repair of anterior vaginal prolapse, we recommend the addition of concomitant midline fascial plication to enhance anatomic outcome." 07/01/2011 - "A systematic review in Medline of reports published between 1950 and November 2010 on adverse events after vaginal prolapse repairs using graft materials was carried out. "
5.	Suburethral Slings (Tension-Free Vaginal Tape) 10/01/2014 - "Little information is available on the effects of concomitant vaginal prolapse repair on the outcomes of the transobturator tape (TOT) procedure. " 10/01/2014 - "Does concomitant vaginal prolapse repair affect the outcomes of the transobturator tape procedure in the long term?" 05/01/2005 - "Suburethral sling treatment of occult stress incontinence and intrinsic sphincter deficiency in women with severe vaginal prolapse of the anterior vs posterior/apical compartment." 10/01/2013 - "Study of inside-out technique of trans-obturator tape for treatment of stress urinary incontinence in women with utero-vaginal prolapse." 06/01/2004 - "A 73-year-old woman with stress urinary incontinence and uterine prolapse underwent vaginal hysterectomy followed by tension-free vaginal tape (TVT) placement. "